PhD Thesis

Marques, C.: Lesão celular e controlo de qualidade proteico. Reparação versus degradação Faculdade de Medicina, Universidade de Coimbra, pp.1-249.

Pereira, F: Metanfetamina e/ou morfina: alterações agudas na transmissão dopaminérgica estriatal e neurotoxicidade.

Master Thesis

Caixinha, L: Análise da qualidade da visão em cirurgia refractiva Faculdade de Medicina, Universidade de Coimbra, 2007, pp.1-168.

Abrantes, A.M.: Avaliação da hipóxia tumoral em adenocarcinoma colo-rectal. Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Novembro de 2007.

Chapter in Book

Ambrósio, A.F., Pereira, P., Cunha-Vaz, J.: Diabetic retinopathy, inflammation and proteosome. In: Interaction between neurons and glia in aging and disease. Eds. J.O. Malva, A.C. Rego, R.A. Cunha and C.R. Oliveira. Springer-Verlag, New York, 2007, pp. 475-502.

Botelho, M.F.: Mecânica pulmonar e envelhecimento. In: Envelhecimento e Pulmão. Ed.: Baganha, M.F., Coimbra 2007, pp. 15-31.

Cunha-Vaz, J.G: Characterization and relevance of different diabetic retinopathy phenotypes. In: Diabetic Retinopathy. Lang GE. Ed. Basel, Karger. Dev. Ophthalmol. 2007, 39, 13-30.

Gonçalo, M, Botelho, M.F.: Radiações e Electricidade. In: Fisiopatologia, Fundamentos e Aplicações. Ed. Lidel – edições técnicas, Lda, pp. 79-102.

Internacional Publications

Abrantes, A.M., Gonçalves, A.C., Breda, H, Ribeiro, A.B., Botelho, M.F.: Effect of the PKC-beta inhibitor, enzastaurin, in colorectal cancer and melanoma cell lines. Proc. An. Meet. American Ass. Cancer Res. 2007;48:#5406.

Abrantes, A.M., Serra, E, Figueirinha, R., Rocha-Gonçalves, A., Ponciano, E., Botelho, M.F.: HI-91 vs. MIBI: Colon cancer cells uptake in normoxic and hypoxic conditions. Eur. J. Nucl. Med. Mol. Imaging 2007, 34(2):S224.

Abrantes, A.M., Serra, E., Laranjo, M., Gonçalves, C., Figueirinha, R., Alves, P., Sarmento-Ribeiro, A.B., Ponciano, E., Rocha-Gonçalves, A., Botelho, M.F.: HL-91 uptake and its correlation with molecular alterations in colon cancer cells. In vivo and in vitro studies. Eur. J. Nucl. Med. Mol. Imaging 2007,34(2):S232.

Abreu M. C., Aguiar D., Albuquerque E., Almeida F. G., Almeida P., Amaral P., Auffray E., Bento P., Bruyndonckx P., Bugalho R., Carriço B., Cordeiro H., Ferreira M., Ferreira N. C., Gonçalves F., Lecoq P., Leong C., Lopes F., Lousã P., Luyten J., Martins M. V., Matela N., Mendes P. R., Moura R., Nobre J., Oliveira N, Ortigão C., Peralta L., Rego J., Ribeiro R., Rodrigues P., Santos A. I., Silva J. C., Silva M. M., Tavernier S., Teixeira I. C., Teixeira J. P., Trindade A., Trummer J., Varela J.: Clear-PEM: A PET imaging system dedicated to breast cancer diagnostics. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2007, 571(1-2):81-84.

Álvaro, A.R., Rosmaninho-Salgado, J., Santiago, A.R., Martins, J., Aveleira, C., Santos, P.F., Pereira, T., Gouveia D., Carvalho A.L., Grouzmann E., Ambrósio, A.F., Cavadas, C.: NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Müller cells. Neurochem. Int. 2007, 50:757-763.

Araújo, I.M., Carreira, B.P., Pereira, T., Santos, P.F., Soulet, D., Inácio, A., Bahr, B.A., Carvalho, A.P., Ambrósio, A.F., Carvalho, C.M.: Changes in calcium dynamics following the reversal of the sodium-calcium exchanger have a key role in AMPA receptor-mediated neurodegeneration via calpain activation in hippocampal neurons. Cell Death Differ. 2007, 14:1635-1646.

Botelho, M.F., Zeevaart, J.R., Jansen, D.R., Turtoi, A., Abrantes, A.M., Kolar, Z.I., Neves, M.A., Schneeweiss, F.H.A., Krijger, G.C., Dormehl, I.C.: Comparison of the sizes of the potencial therapeutic bone agents, the polyphosphonate PEI-MP labelled with 117mSn and 186Re. Eur. J. Nucl. Med. Mol. Imaging 2007, 34 (2):S335.

Caramelo, F. J., Almeida, G., Mendes, L., Ferreira, N. C.: Study of an Iterative Super-Resolution Algorithm and Its Feasibility in High-Resolution Animal Imaging with Low-Resolution SPECT Cameras. Proceedings of the IEEE Medical Imaging Conference, 2007, 4452-4456.

Cardoso, R., Gonçalo, M., Tellechea, O., Maia, R., Figueiredo, A.: Livedoid vasculopathy and hypercoagulability in a patient with primary Sjögren’s syndrome. Int J Dermatol 2007: 46: 431-4.

Carreira RS, Miyamoto S, Di Mascio P, Gonçalves LM, Monteiro P, Providência LA, Kowaltowski AJ. Ischemic preconditioning enhances fatty acid-dependent mitochondrial uncoupling. J Bioenerg Biomembr. 2007; 39(4):313-20.

Castelo-Branco M., M. Mendes, A.R. Sebastião, A.S. Reis, M. Soares, J. Saraiva, R. Bernardes, R. Flores, L. Pérez-Jurado, E. Silva: Visual phenotype in Williams-Beuren syndrome challenges magnocellular theories explaining human neurodevelopmental visual cortical disorders. J. Clin. Invest. 2007; 117 (12): 3720-3729.

Coelho, S., Gonçalo, M., Cortesão, E., Leitão, S., Figueiredo, A.: Síndroma de sweet associado a doença mieloproliferativa. Med. Cutan. Iber. Lat. Am. 2007; 35: 185-188.

Coimbra, S., Castro, E., Rocha-Pereira, P., Oliveira H, L Belo, F Reis, S Rocha, A Figueiredo, F Teixeira, A Santos-Silva. Neutrophil activation associated to psoriasis vulgaris severity. J. Eur. Acad. Dermatol. 2007; 21 (Suppl. 1) 15-29.

Couceiro, M., Blanco, A., Ferreira, N.C., Ferreira Marques, R., Fonte, P.: RPC–PET: Status and perspectives. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2007, 580, 2, 915-918.

Couceiro, M., Ferreira, N.C., Fonte, P.: Sensitivity assessment of wide Axial Field of View PET systems via Monte Carlo simulations of NEMA-like measurements. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2007, 580(1):485-488.

Coutinho, A.M., Sousa, I., Martins, M.C., Morgadinho, T., Macedo, T., Bento, C., Marques, C., Ataíde, A., Miguel, T., Borges, L., Oliveira, G., Vicente, A.M.: Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels. Human Genetics 2007, 121 (2):243-56.

Cravo, M., Gonçalo, M., Figueiredo, A.: Fixed drug eruption to cetirizine with positive lesional patch tests to the three piperazine derivatives. Int. J. Dermatol. 2007: 46:760-762.

Cruz, M.T., Neves, B.M., Goncalo, M., Figueiredo, A., Duarte, C.B., MC Lopes. Effect of skin sensitizers on inducible nitric oxide synthase expression and nitric oxide production in skin dendritic cells: role of different immunosuppressive drugs. Immunopharmacol Immunotoxicol. 2007; 29: 225-41.

Cunha-Oliveira T, Rego AC, Garrido J, Borges F, Macedo T, Oliveira CR. Street heroin induces mitochondrial dysfunction and apoptosis in rat cortical neurons. J. Neurochem. 2007, 101(2):543-54. Epub 2007 Jan 23.

Cunha-Vaz, J.: A European network of certified clinical trials centers of ophthalmology: EVI.CT.SE. Expert. Rev. Ophthalmol. 2007; 2 (1):61-63.

Cunha-Vaz, J.G.: Intravitreal Steroid Injections In Combination With Laser Treatments For Severe Diabetic Retinopathy. Int. Diabetes Monitor. 2007,19(3):36-37.

Cunha-Vaz, J.G: Characterization and relevance of different diabetic retinopathy phenotypes. In: Diabetic Retinopathy. Lang GE. Ed. Basel, Karger. Dev. Ophthalmol. 2007, 39, 13-30.

ESCRS Endophthalmitis Group: Prophylaxis of postoperative endophthalmitis following cataract surgery: Results of the ESCRS multicenter study and indentification of risk factors. J. Cataract.Refract. Surg. 2007, 33:978-988.

European Glaucoma Prevention Study (EGPS) Group, Miglior S, Pfeiffer N, Torri V, Zeyen T, Cunha-Vaz J, Adamsons I. Predictive factors for open-angle glaucoma among patients with ocular hypertension in the European Glaucoma Prevention Study. Ophthalmology. 2007 ;114(1):3-9.

Ferreira, B., Cunha, L, Nunes, A., Abrantes, A.M., Botelho, M.F., Metello, L.: Characterization of Nosocomial Infections in Nuclear Medicine Departments. Eur. J. Nucl. Med. Mol. Imaging 2007, 34(2):S410.

Fontes Ribeiro, C.A., Martins, F., Neta, C., Morgadinho, T., Silva, J., Macedo, T.R.A: Gender differences in the disposition of omeprazole. Basic & Clinical Pharmacology & Toxicology 101(Suppl 1): 127 – 128, 2007

Girão, H., Pereira, P.: The proteasome regulates the interaction between cx43 and zo-1. J. Cell. Biochem. 2007; 102: 719-728

Gomes, C. M. F., Welling, M., Que, I., Henriquez, N.V., Van der Plujm, G., Romeo, S., Abrunhosa, A.J., Botelho, M.F., Hogendoorn, P.C.W., Pauwels, E., Cleton-Jansen, A. M.: Molecular imaging of multidrug resistance in an orthotopic model of osteosarcoma. Laboratory Investigation 2007, 87(1): 15A-15A 46.

Gomes, C.M.F., Abrunhosa, A. J., Pauwels, E. K. J., Botelho M. F.: [99mTc]Sestamibi vs. [99mTc]Tetrofosmin for functional assessment of P-glycoprotein and MRP1-mediated drug resistance in SCLC cell lines. Eur. J. Nucl. Med. Mol. Imaging 2007, 34:(2):S202.

Gomes, C.M.F., Welling, M., Que, I., Henriquez, N.V., Pluijm, G., Romeo, S., Abrunhosa, A.J., Botelho, M.F., Hogendoorn, P.C.W., Pauwels, E., Cleton-Jansen, A.M.: Functional Imaging of Multidrug Resistance in an Orthotopic Model of Osteosarcoma using 99mTc-Sestamibi. Eur. J. Nuc. Med. Mol. Imaging 2007, 34(11):1793-1803.

Gonçalo, M., Nunes, R., Morgado, J., Paiva, A., Figueiredo, A.: Circulating regulatory t cells (cd4+/cd25++) in patients with psoriasis. J Investigative Dermatol 2007; 127: S68.

Leal, E.C., Manivannan, A., Hosoya, K.-I., Terasaki, T., Cunha-Vaz, J., Ambrósio, A.F., Forrester, J.V.: Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 2007, 48:5257-5265.

Lopes, M.F., Botelho, M.F.: Midterm follow-up of esophageal anastomosis for esophageal atresia repair: long-gap versus non-long-gap. Dis. Esophagus 2007,20:428-435.

Lopes, V.S., Ramalho, J.S., Owen, D.M., Karl, M.O., Strauss, O., Futter, C.E., Seabra, M.C.: The ternary Rab27a:Myrip: MyoVIIa complex regulates melanosome motility in the retinal pigment epithelium. Traffic 2007;8(5):486-99.

Macugen AMD Study Group: Pegaptanib 1-year systemic safety results from a safety-pharmacokinetic trial in patients with neovascular age-related macular degeneration. Ophthalmology. 2007 ; 114: 1702-1712.

Metello, L., Cunha, L., Lima, J., Ferrer Antunes, A.I., Abrantes, A.M., Ferreira, B., Nunes, A., Botelho, M.F.: Optimization of Routine Use of Iterative Methods in Myocardial Perfusion Imaging Reconstruction. Eur. J. Nucl. Med. Mol. Imaging 2007,34(2):S400.

Miglior S, Torri V, Zeyen T, Pfeiffer N, Vaz JC, Adamsons I; The European Glaucoma Prevention Study (EGPS) Group: Intercurrent Factors Associated with the Development of Open-Angle Glaucoma in the European Glaucoma Prevention Study Am. J. Ophthalmol. 2007; 144: 266-275.

Neves, B., Cruz, M.T., Gonçalo, M., Figueiredo, A., Duarte, C.B., Lopes, M.C.: Differential cxcr4 expression induced by skin sensitizers or irritants in dendritic cell models. J. Inv. Dermatol. 2007; 127: S5.

Nunes, A., Cunha, L., Ferreira, B., Abrantes, A.M., Botelho, M.F., Metello, L. Optimized Design of an Integrated Nuclear Medicine Department, including Positron Emitting Tracers Production Facility. Eur. J. Nucl. Med. Mol. Imaging 2007, 34( 2):S409.

Nunes, E., Peixoto, F., Louro. T., Sena, C.M., Santos, M.S., Matafome, P., Moreira, P.I., Seiça, R.: Soybean oil treatment impairs glucose-stimulated insulin secretion and changes fatty acids composition of normal and diabetic islets. Acta Diabetol. 2007, 44: 121-130.

Pauwels, E.K.J., Erba, P., Mariani, G., Gomes, C.M.F.: Multidrug Resistance in Cancer: Its Mechanism and its Modulation. Drug News Perspectives 2007, 20(6): 371-378.

Prata, M., Torres, S., Santos, A.C., André, J.P., Martins, J.Á., Neves, M., Helm, L., Tóth, É., Garcia-Martin, M.L., Rodrigues, T.B., López-Larrubia, P., Cerdán, S., Geraldes, C.: A new self-assembling potential liver imaging agent: in vitro characterization and in vivo animal imaging studies. Eur. J. Nucl. Med. Mol. Imaging 2007 34 (Suppl 2):S211.

Santiago, A.R., Cristóvão, A.J., Santos, P.F., Carvalho, C.M., Ambrósio, A.F.: High glucose induces caspase-independent cell death in retinal neural cells. Neurobiol. Dis. 2007, 25:464-472.

Schmidt-Erfurth, U., Richard, G., Augustin, A., Aylward, W. G., Bandello, F., Corcostegui, B., Cunha-Vaz, J., Gaudric, A, Leys, A., Schlingemann, R.O. on behalf of the European Society for Retina Specialists’ Guidelines Committee (EURETINA): Guidance for the treatment of neovascular age-related macular degeneration. Acta Ophthalmol. Scand. 2007, 85:486-494.

Sena, C.M., Barosa, C., Nunes, E., Seiça, R., Jones, J.G.: Sources of endogenous glucose production in the Goto–Kakizaki diabetic rat. Diabetes & Metabolism 2007, 33: 296–302.

Silva, A.P., Lourenço, J., Xapelli, S., Ferreira, R., Kristiansen, H., Woldbye, D.P., Oliveira, C.R., Malva, J.O.:Protein kinase C activity blocks neuropeptide Y-mediated inhibition of glutamate release and contributes to excitability of the hippocampus in status epilepticus.FASEB J. 2007, 21(3):671-81.

Silva, R., Cachulo, M., Figueira, J., Faria de Abreu, J., Cunha-Vaz, J.: Chorioretinal anastomosis and photodynamic therapy. A two-year follow-up study. Graefe’s Arch. of Ophthalmol. 2007, 245: 1131-1139.

Silva, S.A., Marques, F.B., Fontes Ribeiro, C.A.: Characterization of the human basilar artery contractile response to 5-HT and triptans. Fund. Clin. Pharmacol. 2007, 21(3): 265 – 72.

Simões P.F., Silva A.P., Pereira F.C., Marques E., Grade S., Milhazes N., Borges F., Ribeiro C.F. & Macedo T.R.: Methamphetamine induces alterations on hippocampal N-methyl-D-aspartate and AMPA receptor subunit levels and impairs spatial working memory. Neuroscience 2007, 150: 433-41.

Souza, I., Tavares, P., Silvério Cabrita, A.R., Farinha, R., Fontes Ribeiro, C.A.: Skeletal Muscle Morphological Changes in the Experimental Administration of Amphetamine. Exp. Pathol. Health Sciences 2007; 1(1): 33

Souza, I., Rafael, A.I.V., Tavares, P., Silvério Cabrita, A.M., Fontes Ribeiro, C.A.: Liver Morphology in the Experimental Administration of Amphetamine. Exp. Pathol.Health Sciences 2007; 1(1): 37

Souza, I., Rafael, A.I.V., Tavares, P., Silvério Cabrita, A.M., Fontes Ribeiro, C.A.: Heart Morphological Changes in the Experimental Administration of Amphetamine. Exp. Pathol. Health Sciences 2007; 1(1): 37 – 38

Souza, I., Rafael, A.I.V., Tavares, P., Silvério Cabrita, A.M., Fontes Ribeiro, C.A.: Behavioral Evaluation of Experimental Intoxication with Amphetamine. Exp. Pathol. Health Sciences 2007; 1(1): 38.

Tavares, P., Silvério Cabrita, A.M., Farinha, R., Souza, I., Fontes Ribeiro, C.A.: Exercise effect on the rat skeletal muscle histology. Exp. Pathol. Health Sciences 2007; 1(1): 57.

The European Glaucoma Prevention Study Group (EGPS): Central corneal thickness in the European Glaucoma Prevention Study (EGPS). Ophthalmology 2007, 114: 454-459.

Torres, S., Martins, J.A., André, J.P., Neves, M., Santos, A.C., Prata, M.I.M., Geraldes, C.F.G.C.: Radiolabelled 153Sm-chelates of glycoconjugates: multivalence and topology effects on the targeting of the asialoglycoprotein receptor. Radiochim. Act 2007, 95:343-349.

Tralhão, J.G., Abrantes, A.M., Cardoso, D., Figueirinha, R., Lourenço, C., Rovira, E., Ponciano, E., Botelho, M.F., Castro e Sousa, F.J.: Hepatic Extraction Fraction Study by Radioisotopic Method to Evaluate Human Liver Regeneration after Partial Hepatectomy. Eur. J. Nucl. Med. Mol. Imaging 2007, 34(2):S318.

Walker Z, Jaros E, Walker RW, Lee L, Costa DC, Livingston G, Ince PG, Perry R, McKeith I, Katona CL.: Dementia with Lewy bodies: a comparison of clinical diagnosis, FP-CIT single photon emission computed tomography imaging and autopsy. J Neurol Neurosurg Psychiatry. 2007 78(11):1176-81.

Xapelli, S., Silva, A.P., Ferreira, R., Malva, J.O.: Neuropeptide Y can rescue neurons from cell death following the application of an excitotoxic insult with kainate in rat organotypic hippocampal slice cultures.Peptides. 2007,28(2):288-94.