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Functional imaging and translational research in ocular diseases

Coordinator: Rui Bernardes

Imaging is central to clinical diagnosis and to understand the biology of fundamental mechanisms in health and disease.

The objective of the Functional Imaging and Translational Research in Ocular Diseases is to develop and apply recent advances in human and animal ocular imaging toward interdisciplinary solutions to fundamental research questions about the retina and brain.

The re-organization of the institute into the new research areas aims to encourage the coordination and collaboration among experts in basic, translational, and clinical research to advance the understanding of disease onset and progression through imaging and to create better diagnosis and treatment options for patients.

We aim to the non-invasive interrogation and characterization of the central nervous system to progress from anatomical to functional domains. Specifically, we aim to characterize and discriminate between normal ageing and accelerated ageing as in diabetes and CNS diseases like Alzheimer and Multiple Sclerosis. The use of the eye as a window into the brain is of paramount importance and the basis of our research.

Imaging animal models allow to test hypothesis and monitor changes in a fraction of the time as compared to humans.


Structural and functional imaging

Rui Bernardes

Instrumentation development

Miguel Morgado