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UC.PT

IBILI

Ana Paula Pereira da Silva

Ana Paula Silva

Ana Paula Silva obtained her B.Sc. degree in Biology in July 1998 at the Faculty of Sciences and Technology, University of Coimbra, and in January 2003 she obtained her doctorate degree in Cellular Biology at the same University. During her PhD, Ana Paula Silva worked at the Center for Neuroscience and Cell Biology (CNC), Coimbra, and at the Anatomy and Neurobiology Department, Odense University, Denmark, in a project entitled “Neurotoxicity and neuroprotection in the hippocampus: role of neuropeptide Y receptors”. During this period she received an Award from Fundação Calouste Gulbenkian and an Honour Mention from Fundação Professor Francisco Pulido Valente. Afterwards, Ana Paula Silva started working as a postdoctoral research fellow at the CNC and at the Neuropharmacology Laboratory, Faculty of Health and Life Sciences, University Pompeu Fabra, Barcelona, Spain in the scientific project entitled “Neuroprotective effect of neuropeptide Y in excitotoxicity and in temporal lobe epilepsy”. On August 2005, she got a research position at the Institute of Pharmacology and Therapeutics, Faculty of Medicine, University of Coimbra. Ana Paula Silva is the first author of seven scientific papers and co-author of fifteen. She is the supervisor of two PhD and two Master degree students, and the coordinator of two ongoing research projects and collaborator in other two. Moreover, Ana Paula Silva has several national (CNC, IBILI, Faculty of Pharmacy, University of Porto) and international collaborations (Odense University, Denmark; Copenhagen University, Denmark; University of Bordeaux, France; University College London, UK; Institute of Legal Medicine, School of Medicine, Santiago de Compostela, Spain). Scientific Interest:

 The present objectives of Ana Paula Silva research group are to investigate:

1. The role of pro-inflammatory cytokines and neuropeptide Y in methamphetamine-induced hippocampal dysfunction;

2.The impact of methamphetamine on the blood-brain barrier function;

3.The impact of methamphetamine on hippocampal and subventricular zone neurogenesis.

Main topics of interest:

Drugs of abuse; Neuroinflammation; Neurotoxicity; Neuroprotection; Blood-brain Barrier; Neurogenesis; Neuropeptide Y (NPY); Glial cells; Endothelial cells; Epilepsy; Intracellular signalling pathways; Mechanisms of cell death; Ionotropic glutamate receptors; Behaviour studies.

5 Keys Publications:

1. Gonçalves J, Martins T, Ferreira R, Milhazes N, Borges F, Fontes Ribeiro C, Malva JO, Macedo TR, Silva AP. Methamphetamine-induced early increase of IL-6 and TNF-alpha mRNA expression in the mouse brain. Ann N Y Acad Sci, 2008 (in press).

2. Simões PF, Silva AP, Pereira FC, Marques E, Grade S, Milhazes N, Borges F, Ribeiro CF, Macedo TR. Methamphetamine induces alterations on hippocampal NMDA and AMPA receptor subunit levels and impairs spatial working memory. Neuroscience. 2007 Dec 5;150(2):433-41.

3. Silva AP, Lourenço J, Xapelli S, Ferreira R, Kristiansen H, Woldbye DP, Oliveira CR, Malva JO. Protein kinase C activity blocks neuropeptide Y-mediated inhibition of glutamate release and contributes to excitability of the hippocampus in status epilepticus. FASEB J. 2007 Mar;21(3):671-81.

4. Silva AP, Xapelli S, Pinheiro PS, Ferreira R, Lourenço J, Cristóvão A, Grouzmann E, Cavadas C, Oliveira CR, Malva JO. Up-regulation of neuropeptide Y levels and modulation of glutamate release through neuropeptide Y receptors in the hippocampus of kainate-induced epileptic rats.

J Neurochem. 2005 Apr;93(1):163-70.

5. Silva AP, Pinheiro PS, Carvalho AP, Carvalho CM, Jakobsen B, Zimmer J, Malva JO. Activation of neuropeptide Y receptors is neuroprotective against excitotoxicity in organotypic hippocampal slice cultures.

FASEB J. 2003 Jun;17(9):1118-20.

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Email: apmartins@fmed.uc.pt

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