Henrique Manuel Paixão dos Santos Girão

Henrique Girão

Henrique Girão graduated in biochemistry in 1995 from the Faculty of Sciences and Technology of University of Coimbra, Portugal and completed his Ph.D. in 2006 at the Faculty Medicine of University of Coimbra, Portugal. Henrique did part of his PhD work at Department of Biochemistry, University of Dundee (Scotland) and Lab. for Nutrition and Vision Research, Tufts University, Boston, (USA). He moved to Institut de Biologia Molecular de Barcelona - CSIC in 2006 as a PostDoc Research fellow. Henrique is currently head of the Laboratory for Research in Biology of Ageing at COCV, Faculty of Medicine – University of Coimbra, and also the Director of the Laboratory for High-Resolution Cell Bio-imaging – University of Coimbra, which is part of the National Network of Electron Microscopy. Henrique Girão integrates the Coordination Board of the Master in Biomedical Research, of FMUC, and is Member of Directive Board of the PhD programme in Health Sciences and the Inter-University Doctoral Programme in Ageing and Chronic Diseases. Henrique is co-coordinator of the Cardiovacular Area of the FMUC. Henrique has teached and organized several advance courses of Master and PhD programes. Over the last five years Henrique was the Principal Investigator on 3 externally funded (FCT) Research Grants.

Scientific Interest:

His main scientific interests are on molecular mechanisms of age-related cell damage and cell response to stress. He is particularly interested in the mechanisms of age-dependent regulation of proteostasis. This includes the regulation of proteostasis upon ageing and chronic diseases in particular mechanisms of proteolysis including the ubiquitin-proteasome system and autophagy. Henrique has been focused on the role of Ubiquitin as a signal to target lysosomal degradation of membrane proteins, either through the endocytic or autophagic pathway. In particualr, Henrique has been investigating the mechanisms and molecular players involved in the regulation of gap junction intercellular communication and how an impairment of these mechanisms can contribute heart diseases.

Keys Publications:

  • Ferreira JV, Fofo H, Bejarano E, Figueira Bento C, Ramalho JS, Girao H, Pereira P. CHIP/STUB1 is required for HIF-1A degradation by Chaperone-Mediated Autophagy. Autophagy 2013, 9:1-18.
  • Bejarano E*, Girao H*, Yuste A, Patel B, Marques C, Spray D, Cuervo AM, Pereira P. Autophagy modulates dynamics of connexins at the plasma membrane in an ubiquitin-dependent manner. Mol Biol Cell 2012, 23: 2156-69.
  • Catarino SM, Ramalho JS, Marques C, Pereira PC, Girao H. Ubiquitin-mediated internalization of Connexin43 is independent on the canonical endocytic tyrosine-sorting signal. Biochem J. 2011, 437:255-67.
  • Girão H, Catarino S and Pereira P. Eps15 interacts with ubiquitinated Cx43 and mediates its internalization. Exp Cell Res 2009, 315:3587-3597.
  • Girao H, Geli MI, Idrissi FZ. Actin in the endocytic pathway: from yeast to mammals. FEBS Lett. 2008, 582:2112-9.

Phone Number:+351 239480221

Office: IBILI Building, floor 2,

Email: hmgirao@fmed.uc.pt