Paulo Matafome completed the Bsc in Biology in the Faculty of Sciences of University of Lisbon, the Msc in Cellular Biology in the Faculty of Sciences and Technology of University of Coimbra and the PhD in Biomedical Sciences in the Faculty of Medicine of University of Coimbra. He also has the Certification to work with laboratory animals (Portuguese Veterinary Authority – Category C). Since 2005, he is developing his research activities in the IBILI under the supervision of Professor Raquel Seiça and Professor Paulo Pereira. In this period, he has participated in several research projects and had a grant in the project "What HIF? Degradation is better than growth in preventing angiogenesis in diabetic retinopathy", which was coordinated by the Principal Investigator Paulo Pereira. He published 22 articles in international peer-reviewed journals (6 as first author; h factor = 8; Source: Scopus.com).
Since 2010, he is an invited Auxiliary Professor at the College of Health Technology of Coimbra (ESTESC), Polytechnic Institute of Coimbra (IPC). Currently, he is responsible for the discipline of Physiology of the Graduate Studies in Audiology and Physiotherapy and for the discipline of Chemical Physiology and Metabolism of the Master in Health Applied Nuclear Sciences.
His is currently focused on the mechanisms of adipose tissue dysfunction in obesity and type 2 diabetes. Specifically, he is interested in the mechanisms of vascular dysfunction occurring in adipose tissue during its expansion, as recent data strongly suggest that it can be a trigger for systemic dysmetabolism. Based on this, his main goal is to understand the role of glycation-induced microvascular dysfunction during adipose tissue expansion and the subsequent mechanisms.
5 Keys Publications:
· Matafome, P.; Louro, T.; Rodrigues, L.; Crisóstomo, J.; Nunes, E.; Amaral, C.; Monteiro, P.; Cipriano, MA.; Seiça, R. Metformin and atorvastatin combination further protect the liver in type 2 diabetes with hyperlipidemia. Diabetes/Metabolism Research & Reviews. 27(1): 54-62, 2011.
· Matafome P.; Santos-Silva, D.; Crisóstomo, J.; Rodrigues, T.; Rodrigues, L.; Sena, C.M.; Pereira, P.; Seiça. Methylglyoxal causes structural and functional alterations in adipose tissue independently of obesity. Archives of Physiology & Biochemistry. 118(2): 58-68, 2012.
· Matafome P, Sena CM, Seiça R. Methylgyoxal, obesity & diabetes. Endocrine. 43(3):472-84, 2013.
· Matafome P, Santos-Silva D, Sena CM, Seiça R. Common mechanisms of dysfunctional adipose tissue and obesity- related cancer. Diabetes/Metabolism Research & Reviews. 29(4): 285-95, 2013.
T, Matafome P, Seiça R. Methylglyoxal further impairs adipose tissue metabolism
after partial decrease of blood supply. Archives of Physiology &
Biochemistry, 2013. DOI: 10.3109/13813455.2013.812121
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