Ana Raquel Sarabando Santiago
was born in Aveiro on 02 June 1979. She graduated in Biochemistry from the University of Coimbra in June 2002. In 2008 she
completed his Doctoral thesis entitled “Mechanisms of neurodegeneration in the
initial stages of diabetic retinopathy: involvement of glutamate” in Cell
Biology at the Center for Neuroscience and Cell Biology, University of Coimbra,
under the supervision of Dr. António Francisco Ambrósio and Dr. Alistair Barber.
The main scientific interests are glutamate excitotoxicity and neurodegeneration.
5 Keys Publications:
Santiago AR, Hughes JM, Kamphuis W, Schlingemann RO, Ambrósio AF (2008). Diabetes changes ionotropic glutamate receptor subunit expression level in the human retina. Brain Res; 1198:153-9.
Santiago AR, Santos PF, Cristóvão AJ, Carvalho CM, Ambrósio AF (2007). High glucose induces caspase-independent cell death in retinal neural cells. Neurobiol Dis; 25(3):464-472.
Santiago AR, Rosa SC, Santos PF, Cristóvão AJ, Barber AJ, Ambrósio AF (2006). High glucose decreases Ca2+ permeability of AMPA receptors and alters calcium homeostasis in retinal neural cells. Invest. Ophthalmol. Vis. Sci; 47(9):4130-4137.
Santiago AR, Pereira TS, Garrido MJ, Cristóvão AJ, Santos PF, Ambrósio AF (2006). High glucose and diabetes increase the release of [3H]-D-aspartate in retinal cell cultures and in rat retinas. Neurochem Int; 48(6-7):453-458.
EC Leal, Santiago AR, Ambrósio AF (2005). The old and new drug targets in Diabetic Retinopathy: from biochemical changes to inflammation and neurodegeneration. Curr Drug Targets CNS Neurol Disord; 4(4):421-434.
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