Rui Manuel Dias Cortesão dos Santos Bernardes

Rui Bernardes

Assistant Professor at the University of Coimbra (Institute of Biophysics and Biomathematics), Portugal.

His background consists in a Licensure in Electrical Engineering, a Master degree in Biomedical Engineering and a PhD degree in Health Sciences. He works for over 10 years in diabetic retinopathy, developing imaging modalities as the Retinal Leakage Analyser (RLA), a functional imaging system for measuring the permeability of the blood-retinal barrier (BRB), in vivo, and on Multimodal Macula Mapping (MMM), the integration of different imaging modalities to establish relations between different parameters, either morphologic or functional ones, from the human retina.

His contributions led already to the establishment of phenotypes of progression of diabetic retinopathy, and a risk marker for the development of diabetic retinopathy to CSME eyes needing photocoagulation based on the fusion of structure and function data.

He also contributed actively to the development of a quantization process of fluorescence of sodium fluorescein in the human eye, both in serum and vitreous, being this work patented (“Method and apparatus for measuring quantity of a fluorochrome in a biological environment.”. World Intellectual Property Organization. WO 2008/067525 A2, July 5, 2008).

He has been contributing to several national research projects, funded by the national “Fundação para a Ciência e a Tecnologia (FCT)”, as well as in European research projects like the GLAUCAD (Glaucoma Prevention by Computer Aided Diagnostics), EVIGeM (European Virtual Institute for Geometry Measurements) and EVI-GENORET (European Vision Institute – Functional Genomics of the Retina in Health and Disease).

Collaborations with industry include companies as Pfizer Inc. (Groton, CT, USA), Carl Zeiss Meditec (Dublin, CA, USA), Thermofisher (Portsmouth, NH, USA) and Critical Software (Coimbra, Portugal).

Scientific Interest:

Image Processing; Image Analysis; Image Registration; Functional Imaging; Multimodal Imaging.

Keys Publications:

  • R. Bernardes, C. Lobo, and J. Cunha-Vaz. Multimodal macula mapping: A new approach to study diseases of the macula. Surv Ophthalmol, 2002, 47(6):580–589.
  • R. Bernardes, J. Dias, and J. Cunha-Vaz. Mapping the human blood-retinal barrier function. IEEE Trans Biomed Eng, 2005, 52(1):106–116.
  • Castelo-Branco M., Mendes M., Sebastião A., Reis A., Soares M., Saraiva J., Bernardes R., Flores R., Pérez-Jurado L. and Silva E.:Visual phenotype in Williams-Beuren syndrome challenges magnocellular theories explaining human neurodevelopmental visual cortical disorders. J. Clin. Invest. 2007, 117(12): 3720-372.
  • Bernardes R., Santos T., Cunha-Vaz J.: Increased-Resolution OCT Thickness Mapping of the Human Macula: A Statistically Based Registration. Invest. Ophthalmol. Vis. Sci., 2008, 49:2046-2052.
  • Schwartz A., Bernardes R., Franke S., and Morgado A.: Method and apparatus for measuring quantity of a fluorochrome in a biological environment. World Intellectual Property Organization (International Bureau). WO 2008/067525 A2, June 5, 2008.

Phone Number: +351 239480024; +351 239480106

Office: IBILI, Floor 1, Office 80

Email: rmbernardes@fmed.uc.pt