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UC.PT

IBILI

Paulo Fernando Martins dos Santos

Paulo Fernando Martins dos Santos

Paulo Fernando Martins dos Santos was born in Lisbon on 1969. He graduated in Biology in 1992 at the University of Coimbra. In 1995 obtained his Masters degree in Cell Biology, from the University of Coimbra, and in 2000 he acquired his PhD in Molecular and Cellular Biology. Paulo Santos is now Assistant Professor at the Department of Life Sciences of the University of Coimbra and researcher at cnc.ibili. He is also the coordinator of the Masters Programme in Biochemistry, offer by the University of Coimbra.

He published 27 papers in international peer-reviewed journals and was author or co-author of more than 50 presentations at national and international scientific meetings.

During his research, Paulo has tried to understand how diabetes affects the retinal neurons, in order to develop strategies to prevent the death of those cells that occurs in the early stages of diabetic retinopathy.

Scientific Interest:

His main research interest is diabetic retinopathy, particularly on the inflammatory process that that leads to death of retinal neurons that occurs in the early stages of diabetic retinopathy. The development of new pharmacological strategies to prevent the retinal effects of this severe diabetic complication is also one of his purposes.

5 Keys Publications:

1. Vindeirinho J., Costa, G. N., Correia, M. B., Cavadas, C. and Santos, P. F. Effect of diabetes/hyperglycemia on the rat retinal adenosinergic system. PLoS One. (2013) 28;8(6):e67499. doi: 10.1371

2. Costa, G. N., Vindeirinho J., Cavadas, C. Ambrósio, A. F. and Santos, P. F. Contribution of TNF receptor 1 to retinal neural cell death induced by elevated glucose. Mol Cell Neurosci. 50 (2012) 113-23.

3. T.S. Pereira, G. N. Costa, A. R. Santiago, A. F. Ambrósio and P. F. Santos. High glucose enhances intracellular Ca2+ responses triggered by purinergic stimulation in retinal neurons and microglia. Brain Res. 1316 (2010) 129-138.

4. A.R. Santiago, J. M. Gaspar, F. I. Baptista, A. J. Cristovao, P. F. Santos, W. Kamphuis, e A. F. Ambrosio. Diabetes changes the levels of ionotropic glutamate receptors in the rat retina. Mol Vis. 15 (2009) 1620-30.

5. G. Costa, T. Pereira, A. M. Neto, A. J. Cristóvão, A. F. Ambrósio and P. F. Santos. High glucose changes extracellular ATP levels in rat retinal cultures. J. Neurosci. Res. 87 (2009) 1375-1380.

Phone Number:+ 351239480226

Email: pfsantos@ci.uc.pt

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