Maria Filomena Rabaça Roque Botelho
Academic Qualifications:
2000 – “Agregação” in Medicine (Physiological and Technological Sciences – Biophysics). University of Coimbra
1992 – Ph.D. in Medicine (Physiologic Sciences - Biophysics). University of Coimbra
1981 – M.D. University of Coimbra, Portugal
Professional Activity:
2007 – Full Professor
2004 – Director of Biophysics and Biomathematics Institute
1995 – Associate Professor
1992 to 1995 – Assistant Professor
1988 to 1992 – Assistant
1984 to 1988 – Stagiary Assistant
Scientific Interest:
Biophysics; Development of animal models of human diseases (oncology, surgery, ischemia); Nuclear Oncology (from molecular biology to molecular image); Photodynamic therapy in in vitro and in vivo models; Development of liposome for nuclear medicine image and therapy.
Nuclear Medicine; Biodistribution studies of radiopharmaceuticals in experimental animal models; Radiopharmacy; Cell culture.
Keys Publications:
A look at clinical applications and developments of photodynamic therapy". A Serra, M Pineiro, N Pereira, A Rocha Gonçalves, M Laranjo, AM Abrantes, MF Botelho. Oncol Rev 2008;2:189–203. DOI 10.1007/s12156-008-0023-y.
"Cancer and deregulation of stem cells pathways". FC Martins, MF Botelho, AS Cabrita, MI Torgal, C Freire de Oliveira. Oncol Rev 2008;2:197-200. DOI 10.1007/s12156-008-0075-z.
"Radioiodinated ligands for the estrogen receptor:Effect of different 7-cyanoalkyl chains on the binding affinity of novel iodovinyl-6-dehydroestradiols." C Neto, MC Oliveira, L Gano, F Marques, I Santos, GR Morais, T Yasuda, T Thiemann, MF Botelho, Carlos F. Oliveira. Applied Radiation and Isotopes 2008. doi:10.1016/j.apradiso.2008.10.005.
"Pregnancy and its role in breast cancer." FC Martins, MF Botelho, M Laranjo. A Silverio Cabrita, MI Torgal, C Freire de Oliveira. Oncol Rev 2008; 2:141–145.
"Halogen atom effect on photophysical and photodynamic characteristics of derivatives of 5,10,15,20-tetrakis(3-Hydroxyphenyl)porphyrin". AC Serra, M Pineiro, A M d’A Rocha Gonçalves, AM Abrantes, M Laranjo, AC Santos, MF Botelho. J Photoch Photobio B 2008;92:61-67.
"A 99mTc(CO)3-labeled pyrazolyl–α-melanocyte-stimulating hormone analog conjugate for melanoma targeting". PD Raposinho, JDG Correia, S Alves, MF Botelho, AC Santos, I Santos. Nucl Med Biol 2008;35:91–99.
"Functional imaging of multidrug resistance in an orthotopic model of osteosarcoma using 99mTc-Sestamibi". CMF Gomes, M Welling, I Que, NV Henriquez, G van der Pluijm, S Romeo, AJ Abrunhosa, MF Botelho, PCW Hogendoorn, E Pauwels, AM Cleton-Jansen. Eur J Nucl Med Mol I 2007;34:1793–1803.
"Synthesis and biodistribution studies of two novel radioiodinated areno-annelated estra-1,3,5(10), 16-tetraene-3-ols as promising estrogen receptor radioligands". MC Oliveira, M Videira, A Almeida, L Gano, M Watanabe, T Thiemann, AC Santos, MF Botelho, C Oliveira. J Labl Comp Radiophar 2006; 49:559-569.
"Multidrug resistance mediated by abc transporters in osteosarcoma cell lines: mRNA analysis and functional radiotracer studies". CM Gomes, H van Paassen, S Romeo, MM Welling, RIJ Feitsma, AJ Abrunhosa, MF Botelho, PCW Hogendoorn, E Pauwels, AM Cleton-Jansen. Nucl Med Biol 2006, 33:831-840.
"Brain blood flow SPET imaging in heroin abusers". MF Botelho, JS Relvas, AM Abrantes, MJ Cunha, T Reis Marques, E Rovira, CA Fontes Ribeiro, Tice Macedo. Ann New York Acad Sci 2006; 1074:466-477.
Phone Number:+351 239 480240
Email: filomena@ibili.uc.pt