Catarina Oliveira

Catarina Oliveira


Catarina Resende Oliveira


Full Professor

Faculty of Medicine, University of Coimbra Aggregation 1998 Medicine/ Biochemistry
Faculty of Medicine, University of Coimbra MD /Ph. D 1984 Medicine/ Neurology
Faculty of Medicine, University of Coimbra B.A./M.D 1970 Medicine

Research and Professional Experience

Positions and Empoyment

1971-1984 Assistant at Faculty of Medicine - University of Coimbra
1976-1981 Intern of Neurology at Coimbra University Hospital
1981-1989 Junior Consultant of Neurology at Coimbra University Hospital
1984-1991 Assistant Professor at Faculty of Medicine
1991-1998 Associate Professor at Faculty of Medicine - University of Coimbra
1999-Present Full Professor at Faculty of Medicine - University of Coimbra
1989-Present Consultant of Neurology at Coimbra University Hospital
Other Experience

and Professional MemberShips

1991-1999 President of Portuguese Society of Neurochemistry

Vice-President of Portuguese Society of Neurology.

Vice-President of Portuguese Society of Neuroscience

1992-Present Investigator - Center for Neuroscience and Cell Biology University of Coimbra
2003-2005 President of “Instituto de Investigação Interdisciplinar” – University of Coimbra

2003- Present

President of the Center for Neuroscience and Cell Biology of Coimbra University of Coimbra

Member of the Scientific Comission for Health Sciences at FCT

President of Scientific Counsil of the Faculty Medicine - University of Coimbra

2006-Present Associate Editor of the Journal Alzheimer Disease

Academic Honors and Awards


- National Prize, The best student at high school (DR, 2ªserie,27 Jan.1964)

1966 - D.Dinis Prize, The best student at Faculty of Medicine, University of Coimbra
1968 - Boerhinger Prize, The best student in Medical Pathology at Faculty of Medicine/ University of Coimbra
2006 - “Estímulo à Excelência” Prize, Fundação para a Ciência e a Tecnologia (FCT)
2007 - “Homenagem à Mulher Portuguesa – A Mulher Portuguesa saída da Universidade de Coimbra”, Associação dos Antigos Estudantes de Coimbra
2008 “Nunes Correa Verdades de Faria” Prize, Santa Casa da Misericordia de Lisboa

Area of Research

Neuroscience: Neurodegenerative disorders are multifactorial complex disorders of unknown etiopathogenesis. Oxidative stress, excitotoxicity, calcium dyshomeostasis and mitochondrial dysfunction have been suggested to play a key role in cell death occurring in these disorders. The study of these parameters and the evaluation of antioxidant defenses and neuronal reparing mechanisms during the process of ageing and in neurodegenerative diseases such as Parkinson’s, Alzheimer’s and Huntington’s diseases are our main interests of research. The effect of amyloidogenic peptides, beta-amyloid peptide and prion peptide, and alfa-synuclein in neuronal death and glial reactivity are also investigated. The genetics of neurodegenerative diseases is another focus of interest.

B. Peer-reviewed publications in the last 5 years (in inverse chronological order with indication of impact factor).


1. Duarte JM, Oliveira CR, Ambrosio AF, Cunha RA. (2006) Modification of adenosine A1 and A2A receptor density in the hippocampus of streptozotocin-induced diabetic rats. Neurochem. Int. 48(2):144-50.

2. Cunha-Oliveira T, Rego AC, Morgadinho MT, Macedo T, Oliveira CR. (2006) Differential cytotoxic responses of PC12 cells chronically exposed to psychostimulants or to hydrogen peroxide. Toxicology. 217(1):54-62

3. Moreira PI, Custodio J, Moreno A, Oliveira CR, Santos MS. (2006) Tamoxifen and estradiol interact with the flavin mononucleotide site of complex I leading to mitochondrial failure. J Biol Chem. 281(15):10143-52.

4. Moreira PI, Rolo AP, Sena C, Seica R, Oliveira CR, Santos MS. (2006) Insulin attenuates diabetes-related mitochondrial alterations: a comparative study. Med Chem. 2(3):299-308.

5. Almeida S, Brett AC, Gois IN, Oliveira CR, Rego AC. (2006) Caspase-dependent and independent cell death induced by 3-nitropropionic acid in rat cortical neurons. J. Cell Biochem. 98(1):93-101.

6. Cunha-Oliveira T, Rego AC, Cardoso SM, Borges F, Swerdlow RH, Macedo T, de Oliveira CR. (2006) Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine. Brain Res. 1089(1):44-54

7. Garcao P, Oliveira CR, Agostinho P. (2006) Comparative study of microglia activation induced by amyloid-beta and prion peptides: Role in neurodegeneration. J Neurosci Res. 84(1):182-93

8. Moreira P.I., Cardoso S. M., Santos M. S., Oliveira C. R. (2006) The key role of mitochondria in Alzheimer’s disease. J. Alzheimer’s Dis. 101-110.

9. Kofalvi A, Oliveira CR, Cunha RA. (2006) Lack of evidence for functional TRPV(1) vanilloid receptors in rat hippocampal nerve terminals.Neurosci Lett. 403(1-2):151-6

10. Domingues A, Cunha Oliveira T, Laco ML, Macedo TR, Oliveira CR, Rego AC. (2006) Expression of NR1/NR2B N-methyl-D-aspartate receptors enhances heroin toxicity in HEK293 cells. Ann N Y Acad Sci. 1074:458-65.

11. Ferreiro E., Resende R., Costa R., Oliveira C. R., and Pereira C. (2006) An endoplasmic-reticulum-specufic apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity. Neurob. Dis. 669-678.

12. Cunha GM, Canas PM, Oliveira CR, Cunha RA. (2006) Increased density and synapto-protective effect of adenosine A2A receptors upon sub-chronic restraint stress. Neuroscience. 141(4):1775-81.

13. Duarte A.I., Proença T., Oliveira C. R., Santos M. S., and Rego C., Insulin Restores Metabolic Function in Cultured Cortical Neurons Subjected to Oxidative Stress. Diabetes, 2006, 2863-2870.

14. Oliveira J., Chen S., Almeida S., Riley R., Gonçalves J., Oliveira C. R., Hayden R. M., Nicholls G. D., Ellerby M. L., and Rego C. A. (2006) Mitochondrial- Depenent Ca2+ Handling in Huntington’s Disease Striatal Cells: Effect of Histone Deacetylase Inhibitors. Neurobiology of Disease 11174-11186.

15. Moreira P., Santos S., and Oliveira C. R. (2006) Mitochondrial dysfunction, diabetes and Alzheimer’s disease: Pieces from the same puzzle? Mitohondrial Pharmacology and Toxicology 217-236.

16. Grazina M, Pratas J, Silva F, Oliveira S, Santana I, Oliveira C. (2006) Genetic basis of Alzheimer's dementia: role of mtDNA mutations. Genes Brain Behav. 5 Suppl 2:92-107.

17. Cunha-Oliveira T., Rego A. C., Morgadinho M. T., Macedo T., Oliveira C. R. (2006) Efeito crónico da heroína e do peróxido de hidrogénio em células PC12. Coimbra Médica 2, 2129.

18. Milhazes N., Cunha-Oliveira T., Martins P., Garrido J., Oliveira C. R., Rego A. C., and Borges F. (2006) Synthesis and Cytotoxic Profile of 3,4 Methylenedioxymethamphetamine (“Ecstasy”) and Its Metabolites on Undifferentiated PC12 Cells: A Putative Structure-Toxicity Relationship. Chem Res Toxicol. 19(10):1294-304

19. Moreira P.I., Oliveira C.R., (2006) Foreword: Mitochondria in Alzheimer disease. J. Alzheimer’s Disease 99.

20. Correira C, Coitinho AM, Diogo L, Grazina M, Marques C, Miguel T, Ataíde A, Almeida J, Borges L, Oliveira C, Oliveira G, Vivente AM. (2006) Brief Report: High Frequency of Biochemical Markers for Mitochondrial Dysfunction in Autism: No Association with the Mitochondrial Aspartate/Glutamate Carrier SLC25A12 Gene. J. Autism Dev. Disord. 36(8):1137-40.

21. Cunha-Oliveira T, Rego AC, Cardoso SM, Borges F, Swerdlow RH, Mecedo T, Oliveira CR. (2006) Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine. Brain Res. 1089: 44-54.


22. Guerreiro RJ, Santana I, Bras JM, Santiago B, Paiva A, Oliveira C. (2007) Peropheral Inflammatory Cytokines as Biomarkers in Alzheimer’s Disease and Mild Cognitive Impairement. Neurodeg Dis. 4(6):406-12.

23. Silva AP, Lourenço J, Xapelli S, Ferreira R, Kristiansen H, Woldbye DP, Oliveira CR, Malva JO. (2007) Protein kinase C activity blocks neuropeptide Y-mediated inhibition of glutamate  release and contributes to excitability of the hippocampus in status epilepticus. FASEB J. 21(3):671-81

24. Duarte JM, Nogueira C, Mackie K, Oliveira CR, Cunha RA, Köfalvi A. (2007) Increase of cannabinoid CB1 receptor density in the hippocampus of streptozotocin-induced diabetic rats. Exp Neurol. 204(1):479-84

25. Cunha-Oliveira T, Rego AC, Garrido J, Borges F, Macedo T, Oliveira CR. (2007) Street heroin induces mitochondrial dysfunction and apoptosis in rat cortical neurons. J Neurochem. 101(2):543-54.

26. Grazina MM, Diogo LM, Garcia PC, Silva ED, Garcia TD, Robalo CB, Oliveira CR. (2007) Atypical presentation of Leber's hereditary optic neuropathy associated to mtDNA 11778G>A point mutation--A case report. Eur J Paediatr Neurol. 11(2):115-8.

27. Moreira PI, Santos MS, Seiça R, Oliveira CR. (2007) Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes. J Neurol Sci. 257(1-2):206-14. Review.

28. Resende R, Pereira C, Agostinho P, Vieira AP, Malva JO, Oliveira CR. (2007) Susceptibility of hippocampal neurons to Abeta peptide toxicity is associated with perturbation of Ca2+ homeostasis. Brain Res. 1143:11-21

29. Sardão VA, Oliveira PJ, Holy J, Oliveira CR, Wallace KB. (2007) Vital imaging of H9c2 myoblasts exposed to tert-butylhydroperoxide--characterization of morphological features of cell death. BMC Cell Biol. 8:11.

30. Moreira PI, Custódio JB, Nunes E, Moreno A, Seiça R, Oliveira CR, Santos MS. (2007) Estradiol affects liver mitochondrial function in ovariectomized and tamoxifen-treated ovariectomized female rats.Toxicol Appl Pharmacol. 221(1):102-10.

31. Domingues A, Almeida S, da Cruz e Silva EF, Oliveira CR, Rego AC. (2007) Toxicity of beta-amyloid in HEK293 cells expressing NR1/NR2A or NR1/NR2B N-methyl-D-aspartate receptor subunits. Neurochem Int. 50(6):872-80.

32. Melo JB, Agostinho P, Oliveira CR. (2007) Prion protein aggregation and neurotoxicity in cortical neurons. Ann N Y Acad Sci. 1096:220-9.

33. Köfalvi A, Pereira MF, Rebola N, Rodrigues RJ, Oliveira CR, Cunha RA. (2007) Anandamide and NADA bi-directionally modulate presynaptic Ca2+ levels and transmitter release in the hippocampus. Br J Pharmacol. 151(4):551-63.

34. Perfeito R, Pereira J, Oliveira CR, Bettencourt-Relvas J, Rego AC. (2007) Trolox protection of myelin membrane in hydrogen peroxide-treated mature oligodendrocytes. Free Radic Res. 41(4):444-51. Erratum in: Free Radic Res. 2007 Jun;41(6):738-9.

35. Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G. (2007) Autophagocytosis of mitochondria is prominent in Alzheimer disease. J Neuropathol Exp Neurol. 66(6):525-32.

36. Silva CG, Porciúncula LO, Canas PM, Oliveira CR, Cunha RA. (2007) Blockade of adenosine A(2A) receptors prevents staurosporine-induced apoptosis of rat hippocampal neurons. Neurobiol Dis. 27(2):182-9.

37. Santos SC, Vala I, Miguel C, Barata JT, Garção P, Agostinho P, Mendes M, Coelho AV, Calado A, Oliveira CR, e Silva JM, Saldanha C. (2007) Expression and subcellular localization of a novel nuclear acetylcholinesterase protein. J Biol Chem. 282(35):25597-603.

38. Moreira PI, Santos MS, Oliveira CR. (2007) Alzheimer's disease: a lesson from mitochondrial dysfunction. Antioxid Redox Signal. 9(10):1621-30. Review.

39. Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G. (2007) Increased autophagic degradation of mitochondria in Alzheimer disease.Autophagy 3(6):614-5.

40. Machado MV, Ravasco P, Jesus L, Marques-Vidal P, Oliveira CR, Proença T, Baldeiras I, Camilo ME, Cortez-Pinto H. (2007) Blood oxidative stress markers in non-alcoholic steatohepatitis and how it correlates with diet. Scand J Gastroenterol. 1-8

41. Moreira PI, Harris PL, Zhu X, Santos MS, Oliveira CR, Smith MA, Perry G. (2007) Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stressin Alzheimer disease patient fibroblasts. J Alzheimers Dis. 12(2):195-206. Review.

42. Lopes JP, Oliveira CR, Agostinho P. (2007) Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-Beta and prion peptides: implications for Alzheimer's disease and prion-related encephalopathies. Cell Mol Neurobiol. 27(7):943-57.

43. Ferreiro E, Eufrásio A, Pereira C, Oliveira CR, Rego AC. (2007) Bcl-2 Overexpression Protects Against Amyloid-Beta and Prion Toxicity in GT1-7 Neural Cells. J Alzheimers Dis. 12(3):223-8.


44. Rodrigues RJ, Canas PM, Lopes LV, Oliveira CR, Cunha RA. (2008) Modification of adenosine modulation of acetylcholine release in the hippocampus of aged rats. Neurobiol Aging. 29(10):1597-601.

45. Carvalho C, Correia S, Santos MS, Seiça R, Oliveira CR, Moreira PI. (2008) Metformin promotes isolated rat liver mitochondria impairment. Mol Cell Biochem. 308(1-2):75-83.

46. Ferreiro E, Costa R, Marques S, Cardoso SM, Oliveira CR, Pereira CM. (2008) Involvement of mitochondria in endoplasmic reticulum stress-induced apoptotic cell death pathway triggered by the prion peptide PrP(106-126). J Neurochem. 104(3):766-76.

47. Teixeira VH, Jacq L, Moore J, Lasbleiz S, Hilliquin P, Oliveira CR, Cornelis F, Petit-Teixeira E. (2008) Association and Expression Study of PRKCH Gene in a French Caucasian Population with Rheumatoid Arthritis. J Clin Immunol. 28(2):115-21.

48. Bras J, Paisan-Ruiz C, Guerreiro R, Ribeiro MH, Morgadinho A, Januario C, Sidransky E, Oliveira C, Singleton A. (2008) Complete screening for glucocerebrosidase mutations in Parkinson disease patients from Portugal. Neurob. Dis. Sep;30(9):1515-7. (If: 4.852)

49. Bras J, Guerreiro R, Ribeiro M, Morgadinho A, Januario C, Dias M, Calado A, Semedo C, Oliveira C, Hardy J and Singleton A. (2008) Analysis of Parkinson disease patients from Portugal for mutations in SNCA, PRKN, PINK1 and LRRK2. BMC Neurol. 8:1 (This article is available from: http://www.biomedcentral.com/1471-2377/8/1) (If: 2.784).

50. Arduino D, Silva D, Cardoso SM, Chaves S, Oliveira CR, Santos MA. (2008) New hydroxypyridinone iron-chelators as potential anti-neurodegenerative drugs.Front Biosci. 13:6763-74. (If: 3.308)

51. Pupure J, Fernandes MA, Santos MS, Moreno AJ, Kalvinsh I, Klusa V, Oliveira CR. (2008) Mitochondria as the target for mildronate's protective effects in azidothymidine (AZT)-induced toxicity of isolated rat liver mitochondria.Cell Biochem Funct. 26(5):620-31 (If: 1.333)

52. Esteves AR, Domingues AF, Ferreira IL, Januário C, Swerdlow RH, Oliveira CR, Cardoso SM. (2008) Mitochondrial function in Parkinson's disease cybrids containing an nt2 neuron-like nuclear background. Mitochondrion 8(3):219-28. (If: 4.262)

53. Guerreiro RJ, Santana I, Bras JM, Revesz T, Rebelo O, Ribeiro MH, Santiago B, Oliveira CR, Singleton A, Hardy J. (2008) Novel progranulin mutation: Screening for PGRN mutations in a Portuguese series of FTD/CBS cases. Mov Disord. 15;23(9):1269-73 (If: 3.898)

54. Cunha-Oliveira T, Rego AC, Oliveira CR. (2008) Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs. Brain Res Rev. 58(1):192-208. (If: 6.236).

55. Resende R, Moreira PI, Proença T, Deshpande A, Busciglio J, Pereira C, Oliveira CR. (2008) Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease. Free Radic Biol Med. 44(12):2051-7. (If: 5.399)

56. Ferreiro E, Oliveira CR, Pereira CM. (2008) The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway.Neurobiol Dis. (3):331-42. (If: 4.852)

57. Xapelli S, Bernardino L, Ferreira R, Grade S, Silva AP, Salgado JR, Cavadas C, Grouzmann E, Poulsen FR, Jakobsen B, Oliveira CR, Zimmer J, Malva JO. (2008) Interaction between neuropeptide Y (NPY) and brain-derived neurotrophic factor in NPY-mediated neuroprotection against excitotoxicity: a role for microglia.Eur J Neurosci. 27(8):2089-102. (If: 3.385)

58. Domingues AF, Esteves AR, Swerdlow RH, Oliveira CR, Cardoso SM. (2008) Calpain-mediated MPP+ toxicity in mitochondrial DNA depleted cells. Neurotox Res. 13(1):31-8. (If: 2.828)

59. Duarte AI, Santos P, Oliveira CR, Santos MS, Rego AC. (2008) Insulin neuroprotection against oxidative stress is mediated by Akt and GSK-3beta signaling pathways and changes in protein expression.Biochim Biophys Acta. 1783(6):994-1002. (If: 4.579)

60. Resende R, Ferreiro E, Pereira C, Oliveira CR. (2008) ER stress is involved in Abeta-induced GSK-3beta activation and tau phosphorylation. J Neurosci Res. 86(9):2091-9 (If: 3.086)

61. Agostinho P, Lopes JP, Velez Z, Oliveira CR. (2008) Overactivation of calcineurin induced by amyloid-beta and prion proteins. Neurochem Int. 52(6):1226-33. (If: 3.228)

62. Moreira PI, Santos MS, Oliveira CR, Shenk JC, Nunomura A, Smith MA, Zhu X, Perry G. (2008) Alzheimer disease and the role of free radicals in the pathogenesis of the disease.CNS Neurol Disord Drug Targets. 7(1):3-10. (If: 4.697)

63. Cunha GM, Canas PM, Melo CS, Hockemeyer J, Müller CE, Oliveira CR, Cunha RA. (2008) Adenosine A2A receptor blockade prevents memory dysfunction caused by beta-amyloid peptides but not by scopolamine or MK-801. Exp Neurol. 210(2):776-81. (If: 3.974)

64. Carvalho C, Correia S, Santos MS, Seiça R, Oliveira CR, Moreira PI. (2008) Metformin promotes isolated rat liver mitochondria impairment.Mol Cell Biochem. 308(1-2):75-83. (If: 1.764)

Referenced image is missing

65. Guerreiro RJ, Baquero M, Blesa R, Boada M, Brás JM, Bullido MJ, Calado A, Crook R, Ferreira C, Frank A, Gómez-Isla T, Hernández I, Lleó A, Machado A, Martínez-Lage P, Masdeu J, Molina-Porcel L, Molinuevo JL, Pastor P, Pérez-Tur J, Relvas R, Oliveira CR, Ribeiro MH, Rogaeva E, Sa A, Samaranch L, Sánchez-Valle R, Santana I, Tàrraga L, Valdivieso F, Singleton A, Hardy J, Clarimón J. (2008) Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP. Neurob. Aging 31(5):725-31. (If: 5.959)

66. Correia S, Carvalho C, Santos MS, Proença T, Nunes E, Duarte AI, Monteiro P, Seiça R, Oliveira CR, Moreira PI. 2008 Metformin protects the brain against the oxidative imbalance promoted by type 2 diabetes. Med Chem. 4(4):358-64. (If: NA)

67. Paula Agostinho, João P. Lopes, Zélia Velez, Catarina R. Oliveira (2008) Overaction of calcineurin induced by amyloid-beta and prion proteins. Neurochem. Int. 52: 1226-1233. (If: 3.228)

68. M. Matos, E.Augusto, C.R. Oliveira and P. Agostinho (2008) Amyloid-Beta Peptide decreases Glutamate uptake in cultured astrocytes: Involvement of oxidative stress and mitogen-activated protein kinase cascades. Neuroscience. 156: 898-910 (If: 3.556)

69. Correia S, Carvalho C, Santos MS, Seiça R, Oliveira CR, Moreira PI (2008) Mechanisms of Action of Metformin in type 2 Diabetes and Associated complications: An overview. Mini-reviwes in Med. Chem. 8: 1343-1354. (If: 3.132)

70. Baldeiras I, Santana I, Proença MT, Garrucho MH, Pascoal R, Rodrigues A, Durob D and OliveiraCR (2008) Peripheral Oxidative Damage in Mild Cognitive Impairment and Mild Alzheimer’s Disease. J.A.D. 15: 117–128


71. Sardão VA, Oliveira PJ, Holy J, Oliveira CR, Wallace KB. (2009) Morphological alterations induced by doxorubicin on H9c2 myoblasts: nuclear, mitochondrial, and cytoskeletal targets. Cell Biol Toxicol. 25(3):227-43

72. João P. Lopes, Catarina R. Oliveira and Paula Agostinho. (2009) Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-β and prion peptides. Cell Cycle, 8:1, 97-104

73. Moreira PI, Duarte AI, Santos MS, Regi AC, Oliveira CR (2009) An Integrative view of the Role of Oxidative Stress, Mitochondria and Insulin in Alzheimer’s Disease. J. Alz. Dis. 16: 741-761.

74. Diogo L, Grazina M, Garcia P, Rebelo O, Veiga MA, Cuevas J, Vilarinho L, Almeida IT, Oliveira CR (2009) Pediatric Mitochondrial respiratory chain disorders in the Centro Region of Portugal. Pediatric Neurol. 40:5 351-356.

75. Lopes JP, Oliveira CR, Agostinho P (2009) Cell Cycle Re-Entry in Alzheimer’s Disease. A major Neuropathological Characteristic? Curr. Alz Res. 6:3.

76. Cardoso SM, pereira CF, Moreira OI, Arduino DM, Esteves AR, Oliveira CR (2009) Mitochondrial control of autophagic Lysosomal pathway in Alzheimer’s Disease. Exp. Neurol. 223(2):294-8

77. Arduino DM, Esteves AR, Cardoso SM, Oliveira CR (2009) Endoplamic reticulum and mitochondria interplay mediates apoptotic cell death: Relevance to Parkinson’s disease. Neurochem. Int. 55(5):341-8

78. Melo JB, Sousa C, Garção P, Oliveira CR, Agostinho P (2009) Galantamine protects against oxidative stress induced by amyloid-beta peptide in cortical neurons. Eur. J. Neurosc. 29: 445-464.

79. Sardão VA, Oliveira PJ, Holly J, Oliveira CR, Wallace KB (2009) Doxorubicin-induced mitochondrial dysfunction is secondary to nuclear p53 activation in H9c2 cardiomyoblasts. Cancer Chemother Pharmacol. 64(4):811-27

80. Fonseca ACRG, Proença T, Resende R, Oliveira CR, Pereira CMF (2009) Neuroprotective effects of Statins in an in Vivo Model of Alzheimer’s Disease. JAD 17(3):503-17

81. Baldeiras IE, Ribeiro MH, Pacheco P, Machado A, Santana I, Cunha L, Oliveira CR (2009) Diagnostic value of CSF protein profile ia a Portuguese population of sCJD patients. J. Neurol. 256(9):1540-50.

82. Silva A, Pereira J, Oliveira CR, Relvas JB, Rego AC (2009) BDNF and Extracellular Matrix Regulate Differentiation of Mice Neurosphere-Derived Cells into a GABAergic Neuronal Phenotype. J. Neurosc. Res. 87:1986-1996.

83. Ferreira SG, Lomaglio T, Avelino A, Cruz F, Oliveira CR, Cunha RA, Kofalvi A (2009) N-acyldopamines control striatal input terminals via novel ligand-gated cation channels. Neuropharmacol. 56:676-683.

84. Almeida S, Cunha-Oliveira T, Oliveira CR, Rego AC (2009) BDNF regulates BIM expression levels in 3-nitropropionic cortical neurons. Neurobiol. Dis. 3: 448-56

85. Cardoso S, Correia S, Santos R, Carvalho C, Santos MS, Oliveira CR, Perry G, Smith M, Zhuf X and Moreira PI (2009) Insulin is a Two-Edged Knife on the Brain. JAD. 18: 483–507.

86. Teixeira VH, Olaso R, Martin-Magniette ML, Lasbleiz S, Jacq L, Oliveira CR, Hilliquin P, Gut I, Cornelis F, Petit-Teixeira E. (2009)Transcriptome analysis describing new immunity and defense genes in peripheral blood mononuclear cells of rheumatoid arthritis patients. PLoS One. 4(8):e6803.

87. Almeida S, Cunha-Oliveira T Laço M, Oliveira CR, Rego AC (2009) Dysregulation of CREB Activation and Histone Acetylation in 3-Nitropropionic Acid-Treated Cortical Neurons: Prevention by BDNF and NGF. Neurotox Res. 17(4):399-405.

88. Sidransky E, Nalls MA, Aasly JO, Aharon-Peretz J, Annesi G, Barbosa ER, Bar-Shira A, Berg D, Bras J, Brice A, Chen C-M, Clark LN, Condroyer C, De Marco EV, Dürr A, Eblan MJ, Fahn S, Farrer MJ, Fung H-C, Gan-Or Z, Gasser T, Gershoni-Baruch R, Giladi N, Griffith A, Gurevich T, Januario C, Kropp P, Lang AE, Lee-Chen G-J, Lesage S, Marder K, Mata IF, Mirelman A, Mitsui J, Mizuta I, Nicoletti G, Oliveira C, Ottman R, Orr-Urtreger A, Pereira LV, Quattrone A, Rogaeva E, Rolfs A, Rosenbaum H, Rozenberg R, Samii A, Samaddar T, Schulte C, Sharma M, Singleton A, Spitz M, Tan E-K, Tayebi N, Toda T, Troiano AR, Tsuji S, Wittstock M, Wolfsberg TG, Wu Y-R, Zabetian CP, Zhao Y, and Ziegler SG (2009) Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson’s Disease. N Engl J Med. 361:1651-61.

89. Moreira PI, Cardoso SM, Pereira CM, Santos MS and Oliveira CR (2009) Mitochondria as a Therapeutic Target in Alzheimer’s Disease and Diabetes. CNS & Neurological Disorders - Drug Targets, 8, 492-511.

90. Canas PM, Porciúncula LO, Cunha GM, Silva CG, Machado NJ, Oliveira JM, Oliveira CR, Cunha RA (2009) Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway. J Neurosci. 29(47):14741-51.

91. Arduino DM, Esteves AR, Domingues AF, Pereira CM, Cardoso SM, Oliveira CR (2009) ER-mediated stress induces mitochondrial-dependent caspases activation in NT2 neuron-like cells. BMB Rep. 42(11):719-24


92. Lopes JP, Oliveira CR, Agostinho P (2009) Neurodegeneration in an A-Beta-induced model of Alzheimer’s disease: the role of Cdk5. Aging Cell , Feb;9(1):64-77

93. Ferreira IL, Nascimento MV, Ribeiro M, Almeida S, Cardoso SM, Grazina M, Pratas J, Santos MJ, Januário C, Oliveira CR, Rego AC (2010) Mitochondrial-dependent apoptosis in Huntington's disease human cybrids. Exp Neurol. 222(2):243-55.

94. do Carmo A, Patricio I, Cruz MT, Carvalheiro H, Oliveira CR, Lopes MC. (2010) CXCL12/CXCR4 promotes motility and proliferation of glioma cells. Cancer Biol Ther. Jan 17;9(1).

95. Correia SC, Santos RX, Cardoso S, Carvalho C, Santos MS, Oliveira CR, Moreira PI. Effects of estrogen in the brain: is it a neuroprotective agent in Alzheimer’s disease? Curr Aging Sci. 2010;3:113-126.

96. Costa RO, Ferreiro E, Cardoso SM, Oliveira CR, Pereira CM. (2010) Endoplasmic reticulum stress-mediated apoptotic pathway induced by Aβ1-40 peptide requires the presence of functional mitochondria. J Alzheimer Dis 20(2):625-36

97. Guerreiro RJ, Beck J, Gibbs R, Santana I, Rossor MN, Schott J M, Nalls MA, Ribeiro H, Santiago B, Fox C, Oliveira C, Collinge J, Mead S, Singleton A, Hardy J. (2010) Genetic Variable in CLU and Its Association with Alzheimer´s disease. Plos One. 5: 3, e9510

98. Cardoso SM, Pereira CF, Moreira PI, Arduíno DM, Esteves AR, Oliveira CR. (2010) Mitochondrial control of autophagic lysosomal pathway in Alzheimer´s disease. Experimental Neurology 223 294-298

99. Arduíno DM, Esteves AR, Oliveira CR and Cardoso SM. (2010) Mitochondrial Metabolism Modulation: A New Therapeutic Approach for Parkinson´s Disease. CNS & Neurological Disorders – drug Targets (1):105-19.

100. Cunha-Oliveira T, Rego AC, Garrido J, Borges F, Macedo T, Oliveira CR. (2010) Neurotoxicity of heroin-cocaine combinations in rat cortical neurons. Toxicology 276(1):11-7.

101. Esteves AR, Arduíno DM, Swerdlow RH, Oliveira CR, Cardoso SM (2010) Dysfunctional mitochondria uphold calpain activation: Contribution to Parkinson's disease pathology. Neurobiol Dis. 37(3):723-30

102. Carvalho C, Santos MS, Baldeiras I, Oliveira CR, Seiça R, Moreira PI. (2010) Chronic Hypoxia Potentiates Age-Related Oxidative Imbalance in Brain Vessels and Synaptosomes. Curr Neurovasc Res. 7: 288-300.

103. Correia SC, Carvalho C, Cardoso S, Santos RX, Santos MS, Oliveira CR, Perry G, Zhu X, Smith MA, Moreira PI. (2010) Mitochondrial preconditioning: a potential neuroprotective strategy. Front Aging Neurosci. Aug 26;2. pii: 138.

104. Marques SC, Oliveira CR, Pereira CM, Outeiro TF. (2010) Epigenetics in neurodegeneration: A new layer of complexity. Prog Neuropsychopharmacol Biol Psychiatry. Aug 22. [Epub ahead of print]

105. Baldeiras I, Santana I, Proença MT, Garrucho MH, Pascoal R, Rodrigues A, Duro D, Oliveira CR. (2010) Oxidative Damage and Progression to Alzheimer's Disease in Patients with Mild Cognitive Impairment. J Alzheimers Dis. Aug 6. [Epub ahead of print]

106. Branco DM, Arduino DM, Esteves AR, Silva DF, Cardoso SM, Oliveira CR. (2010) Cross-talk between mitochondria and proteasome in Parkinson's disease pathogenesis. Front Aging Neurosci. 2:17.

107. Marques SC, Oliveira CR, Outeiro TF, Pereira CM. (2010) Alzheimer's disease: the quest to understand complexity. J Alzheimers Dis. 21(2):373-83.

108. Esteves AR, Arduíno DM, Swerdlow RH, Oliveira CR, Cardoso SM. (2010) Microtubule depolymerization potentiates alpha-synuclein oligomerization. Front Aging Neurosci;1:5.

109. Diogo L, Cordeiro M, Garcia P, Fineza I, Moura C, Oliveira CR, Veiga M, Garcia T, Grazina M. (2010) Value of brain magnetic resonance imaging in mitochondrial respiratory chain disorders. Pediatr Neurol. 42(3):196-200.

110. Fonseca AC, Resende R, Oliveira CR, Pereira CM. (2010) Cholesterol and statins in Alzheimer's disease: current controversies. Exp Neurol. 223(2):282-93.


111. Moreira PI, Custódio JB, Nunes E, Oliveira PJ, Moreno A, Seiça R, Oliveira CR, Santos MS. (2011) Mitochondria from distinct tissues are differently affected by 17β-estradiol and tamoxifen. J Steroid Biochem Mol Biol. 123(1-2):8-16.

112. Diana FF, Silva Esteves AR, Oliveira CR, Cardoso SM. (2011) Mitochondria: The Common Upstream Driver of Abeta and Tau Pathology in Alzheimer´s Disease. Curr Alzheimer Res. [Epub ahead of print]

113. Cardoso S, Carvalho C, Santos R, Correia S, Santos MS, Seiça R, Oliveira CR, Moreira PI. (2011) Impact of STZ-induced hyperglycemia and insulin-induced hypoglycemia in plasma amino acids and cortical synaptosomal neurotransmitters. Synapse. 65:457-466.

114. Moreira PI, Oliveira CR. (2011) Mitochondria as potential targets in antidiabetic

Therapy.Handb Exp Pharmacol. (203):331-56.

115. Marques SC, Oliveira CR, Pereira CM, Outeiro TF. (2011) Epigenetics in neurodegeneration: a new layer of complexity. Prog Neuropsychopharmacol Biol Psychiatry. 35(2):348-55. Epub 2010 Aug 22.

116. Mota-Pinto A, Rodrigues V, Botelho A, Veríssimo MT, Morais A, Alves C, Rosa MS, de Oliveira CR. (2011) A socio-demographic study of aging in the Portuguese population: the EPEPP study. Arch Gerontol Geriatr. 52(3):304-8.

117. 115. Esteves AR, Arduíno DM, Silva DF, Oliveira CR, Cardoso SM. (2011) Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD. Parkinsons Dis. 2011:693761.

Total Number: 293; Total Number of Citations: around 2000

C. Research Supervision

Supervisor of several BSc thesis (Biology and Biochemistry) Supervisor of 17 Master thesis (concluded) Supervisor of 19 PhD thesis (concluded)

D. Research Support

Ongoing Research support:

As Principal investigator:

- “Estudo do Perfil do Envelhecimento da População Portuguesa” (EPEPP/Saude XXI)

- “Caracterização de alterações genéticas em gliomas humanos por arrays de polimorfismos de nucleótido único: Correlação com as características clínicas e biológicas e citognéticas da doença.” (PIC/IC/83108/2007)

- “Localização e Metabolismo da APP e Relação com o controlo da Degeneração sináptica em modelos animais da Doença de Alzheimer”. (PTDC/SAU-MMC/114810/2009)

Completed Research Support

As principal investigator:

- “Membrane changes and senescence” (JNICT, PMCT/C/IMU/583/87);

- “Oxidative Damage of Retina. Relationship with aging and diabetes” (JNICT, PMCT/C/SAU/217/90); - “Development of excitable cells in culture and adaptation to oxidative stress” (PRAXIS XXI, 2/2.1/BIA/126/94);

- “Postreceptor events in glutamate neurotoxicity in retina cells.” (PRAXIS/P/SAU/14 120/98);

- “A comparative study of the neurotoxic mechanisms of prion and amyloid-beta peptides. Potential neuroprotective strategies.” (POCTI/36101/NSE/2000);

- "Neuroprotective effect of neuropeptide Y in excitotoxicity and in temporal lobe epilepsy” (POCTI/NSE/46848/2002);

- "Biochemical and Behavioural Study of Opioid - Cocaine Interactions" (POCTI/SAU-FCT/58330/2004) - "Neuroprotecção por receptores de adenosina: acoplar o aumento da formação de adenosina com o bloqueio de receptores A2A" (POCI/SAU-FCF/59215/2004)