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Carlos Frederico de Gusmão Campos Geraldes

Categoria profissional: Professor Catedrático

Morada institucional: Departamento de Ciências da Vida
Faculdade de Ciências e Tecnologia
Universidade de Coimbra
Calçada Martim de Freitas
3000-456 Coimbra
Portugal

Gabinete: 2º Piso do Colégio de S. Bento

Telefone: +351 239 240 730

Extensão interna: 262 230

Fax: +351 239 240 701

Email: geraldes@ci.uc.pt

URL de página pessoal: http://www.cnbc.pt/research/areaE1_2.asp?lg=2<

Áreas de interesse: RMN biomédico e Imagem molecular. Desenvolvimento e avaliação de agentes de conrase para imagem por ressonância magnética e Imagem molecular multimodal. Nanosistemas para teragnóstica e imagem multimodal. Estudos da interação entre pequenos ligandos e proteinas por RMN. Estrutura de proteinas (laforina) e ligação a oligosacarídesos estudados por técnicas de RMN

Publicações mais relevantes/recentes:

Co-autor de 229 publicações SCI, (4322 citações, h-factor: 33), um livro (Fundação Calouste Gulbenkian) e 14 capítulos de livros. “Prémio de Excelência Científica da FCT, Portugal, 2004)

Alves FC,Donato P, Sherry AD, Zaheer A,  Zhang S, Lubag AJ, Merritt ME, Lenkinski RE, Frangioni JV, Neves M, Prata MIM, Santos AC,Lima JJP, Geraldes CFGC, Silencing of Phosphonate-Gadolinium MRI Contrast by Hydroxyapatite Binding, Invest Radiol 2003; 38: 750-760.

Prata MIM, Santos AC, S. Torres, J.P. André, J.A. Martins, M.Neves, M.L. García-Martín, T.B. Rodrigues, P. López-Larrubia, S.Cerdán and Geraldes CFGC, Targeting of lanthanide(III) chelates of DOTA-type glycoconjugates to the hepatic a yaloglycoprotein receptor: cell internalization and animal imaging studies Contrast Media Mol. Imaging, 2006; 1: 246-258.

Torres S,Prata MIM, Santos AC, André JP, Martins JA, Helm L, Tóth É, García-Martín ML, RodriguesTB, López-Larrubia P, Cerdán S,  Geraldes CFGC, Gd(III)-EPTPAC16, a new self-assembling potential liver MRI contrast agent: in vitro characterization and in vivo animal imaging studies, NMR in Biomedicine, 2008; 21: 322–336.

Woods M, Caravan P, Geraldes CFGC, Greenfield MT, Kiefer GE, Lin M, McMillan K, Prata MIM, Santos AS, Sun X, Wang J, Zhang S, Zhao P, Sherry AD, The Effect of the Amide Substituent on the Biodistribution and Tolerance of Lanthanide(III) DOTA-Tetraamide Derivatives.  Invest Radiol 2008; 43:861-70.

Ferreira MF, Martins AF, Martins JA, Ferreira PM, Tóth É, Geraldes CFGC,  Gd(DO3A-N-α-aminopropio nate): a versatile and easily available synthon with optimized water exchange for the synthesis of high relaxivity, targeted MRI contrast agents, Chem. Commun., 2009; 6475-6477.

Polášek M, Hermann P, Peters JA, Geraldes CFGC,  Lukeš I, PAMAM dendrimers conjugated with an uncharged gadolinium(iii) chelate with a fast water exchange: the influence of chelate charge on rotational dynamics,Bioconj. Chem., 2009; 20: 2142–2153.

Geraldes CFGC, Laurent S, Classification and Basic Properties of Contrast Agents for Magnetic Resonance Imaging, Contrast Media Mol. Imaging, 2009; 4: 1-23.

Pereira GA,Peters JA, Paz FV, Rocha J, Geraldes CFGC, Evaluation of [Ln(H2cmp)(H2O)] Metal Organic Framework Materials for Potential Application as MRI Contrast Agents, Inorganic Chemistry, 2010; 49: 2969–2974.

Geraldes CFGC, Djanashvili K, Peters JA, Glycoconjugate probes and targets for molecular imaging using MRI, Future Medicinal Chem., 2010; 2: 409–425.

Pinho SLC, Pereira GA, Voisin P, Kassem J, Bouchaud V, Etienne L,Peters JA, Carlos L, Mornet S, Geraldes CFGC, Rocha J, Delville MH, Fine tuning of the relaxometry of γ-Fe2O3 nanoparticles by tweaking the thickness of the silica coating, ACS Nano, 2010; 4: 5339–5349.

Gallium labeled NOTA-based conjugates for peptide receptor-mediated medical imaging
Arsénio de Sá, M. Áurea A. Martins, Isabel M. Prata, Carlos F. G. C. Geraldes, P.M.T. Ferreira, João P. André Bioorg. Med. Chem. Lett., 20, 7345–7348 (2010).

A Gallium Complex with a New Tripodal Tris-Hydroxypyridinone for Potential Nuclear Diagnostic Imaging: Solution and in vivo Studies of 67Ga-Labeled Species
Silvia Chaves, Ana C. Mendonça, Sérgio M. Marques, Maria I.M. Prata, Ana C. Santos, André F. Martins, Carlos F.G.C. Geraldes, M. Amélia Santos
J. Inorg. Biochem., 105, 31-38 (2011).

Comparison of different phosphorus-containing ligands complexing 68Ga for PET-imaging of bone metabolism
M. Fellner, P. Riß, N. Loktionova, K. Zhernosekov, O. Thews, C.F.G.C. Geraldes, Z. Kovacs, I. Lukeš, F. Rösch
Radiochimica Acta, 99, 43-51 (2011).

Supramolecular Protamine/Gd-loaded Liposomes Adducts as Relaxometric Protease Responsive Probes
Sara Figueiredo, João Nuno Moreira, Carlos F.G.C. Geraldes, Silvio Aime, Enzo Terreno
Bioorg. Medicinal Chem., 19, 1131-1135 (2011).

Ga(III) chelates of amphiphilic DOTA-based ligands: synthetic route and in vitro and in vivo studies
André Fontes, M. Isabel M. Prata, Carlos F. G. C. Geraldes, João P. André
Nucl. Med. Biology, 38, 363-370 (2011).

The Interaction of La3+ Complexes of DOTA/DTPA-Glycoconjugates with the RCA120 lectin: A Saturation Transfer Difference (STD) NMR Spectroscopic Study
João M. C. Teixeira, David M. Dias, F. Javier Cañada, José A. Martins, João P. André, Jesús Jiménez-Barbero, and Carlos F. G. C. Geraldes
J. Biol. Inorg. Chem., 16, 725-734 (2011).

Interaction of carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP) with lipid membrane systems: a biophysical approach with relevance to mitochondrial uncoupling
João P. Monteiro, André F. Martins, Marlene Lúcio, Salette Reis, Carlos F.G.C Geraldes, Paulo J. Oliveira and Amália S. Jurado
J. Bioenerg. Biomembranes, 43, 287–298 (2011).

Enantioselective binding of a lanthanide(III) complex to human serum albumin studied by 1H STD NMR techniques
David M. Dias, João M.C. Teixeira, Ilya Kuprov, Elizabeth J. New, David Parker and Carlos F.G.C. Geraldes
Org. Biomol. Chem., 9, 5047-5050 (2011).

Yeast Cell Wall Particles: a promising class of nature-inspired microcarriers for
multimodal imaging
Sara Figueiredo, João Nuno Moreira, Carlos F.G.C. Geraldes, Silvia Rizzitelli, Silvio Aime, Enzo Terreno
Chem. Comm., 47, 10635-10637 (2011).

Gd(III) Chelates as NMR Probes of Protein-Protein Interactions. Case Sudy: Rubredoxin and Cytochrome c3
Rui M. Almeida, Carlos F. G. C. Geraldes, Sofia R. Pauleta, José J. G. Moura
Inorg. Chem., 50, 10600-10607 (2011).

Lanthanide-DTPA Grafted Silica Nanoparticles as Bimodal-Imaging Contrast Agents
Sonia L. C. Pinho,  Henrique Faneca, Carlos F.G.C. Geraldes, Marie-Hélène Delville, Luís D. Carlos, João Rocha
Biomaterials, 33, 925-935(2012).