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UC.PT

Departamento de Ciências da Vida

Foto
João Ramalho de Sousa Santos

Categoria profissional: Professor Associado com Agregação

Morada institucional: Departamento de Ciências da Vida
Faculdade de Ciências e Tecnologia
Universidade de Coimbra
Calçada Martim de Freitas
3000-456 Coimbra
Portugal

Gabinete: Biblioteca antiga (Colégio de Jesus)

Telefone: +351 239 240 763

Extensão interna: 262 263

Fax: + 351 239 240 701

Email: jramalho@ci.uc.pt

URL de página pessoal: http://www.cnbc.pt/researc/areaF1_2.asp?lg=2

Áreas de interesse: Diversos aspectos relacionados com Biologia da Reprodução, desde a gametogénese às células estaminais embrionárias, focando aspectos relacionados com o metabolismo, a produção de energia e a função mitocondrial.

Publicações mais relevantes/recentes:

Not all sperm are equal: Functional mitochondria characterize a subpopulation of human sperm with better fertilization potential (2011) Ana Paula Sousa, Alexandra Amaral, Marta Baptista, Renata Tavares, Pedro Caballero-Campo, Pedro Caballero-Peregrín, Albertina Freitas, Artur Paiva, Teresa Almeida-Santos & João Ramalho-Santos PLoS ONE 6(3): e18112.

Human procreation in unchartered territory: New twists in ethical discussions (2011) João Ramalho-Santos, Human Reproduction 26: 1284-1287.

Energy metabolism of human pluripotent stem cells and their differentiated counterparts (2011) Sandra Varum, Ana Sofia Rodrigues, Michelle B. Moura, Olga Momcilovic, Charles Easley, João Ramalho-Santos, Bennett Van Houten & Gerald Schatten PLoS ONE 6 (6): e20914.

Enhancement of human embryonic stem cell pluripotency through inhibition of the mitochondrial respiratory chain (2009) Sandra Varum, Olga Momcilovic, Carlos Castro, Ahmi Ben-Yehudah, João Ramalho-Santos* & Christopher S. Navara* (*co-corresponding authors). Stem Cell Research 3: 142-156.

Mitochondrial functionality and reproduction: From gonads and gametes to embryos and embryonic stem cells (2009) João Ramalho-Santos, Sandra Varum, Sandra Amaral, Paula C. Mota, Ana Paula Sousa & Alexandra Amaral. Human Reproduction Update 5: 553-572.

Dual use of Diff-Quik-like stains for the simultaneous evaluation of human sperm morphology and chromatin status (2009) Ana Paula M. Sousa, Renata S. Tavares, Juan Felipe Velez de la Calle, Helena Figueiredo, Vasco Almeida, Teresa Almeida-Santos & João Ramalho-Santos Human Reproduction 24:28-36.

Testicular aging involves mitochondrial dysfunction and UCP2-mediated proton leak (2008) Sandra Amaral, Paula Mota, Ana Sofia Rodrigues, Luís Martins, Paulo J. Oliveira & João Ramalho-Santos. FEBS Letters 582:4191-4196

The expression of polymerase gamma and mitochondrial transcription factor A and the regulation of mitochondrial DNA content in mature human sperm (2007) Alexandra Amaral, João Ramalho-Santos & Justin St. John. Human Reproduction 22:1585-1596.

The expression of mitochondrial DNA transcription factors during early cardiomyocyte in vitro differentiation from human embryonic stem cells (2005) Justin St. John*, João Ramalho-Santos*, Heather Gray, Christopher Navara, Vanesa Y. Rawe, Patti Petrosko, Calvin Simerly & Gerald Schatten (*Co-first authors). Cloning & Stem Cells 7:141-153.

ICSI choreography: Fate of sperm structures after monospermic ICSI and first cell cycle implications (2001) João Ramalho-Santos, Peter Sutovsky, Calvin R. Simerly, Richard Oko, Gary M. Wessel, Laura Hewitson & Gerald Schatten, Human Reproduction, 15: 2610-2620.

Membrane trafficking machinery components associated with the mammalian acrosome during spermiogenesis (2001) João Ramalho-Santos, Ricardo D. Moreno, Gary M. Wessel, Edward K. L. Chan & Gerald Schatten, Experimental Cell Research, 267: 45-60.

SNAREs in mammalian sperm: Possible implications for fertilization (2000) João Ramalho-Santos, Ricardo D. Moreno, Peter Sutovsky, Anthony Wing-Sang Chan, Laura Hewitson, Gary M. Wessel, Calvin R. Simerly & Gerald Schatten, Developmental Biology, 223: 54-69.

Ubiquitin tag for sperm mitochondria (1999) Peter Sutovsky, Ricardo D. Moreno, João Ramalho-Santos, Tanja Dominko, Calvin Simerly & Gerald Schatten, Nature, 402: 371-372.

Unique checkpoints during the first cell cycle of fertilization after intracytoplasmic sperm injection in rhesus monkeys (1999) Laura Hewitson, Tanja Dominko, Diana Takahashi, Crista Martinovich, João Ramalho-Santos, Peter Sutovsky, John Fanton, Darla Jacob, Daymond Monteith, Martha Neuringer, David Battaglia, Cal Simerly & Gerald Schatten, Nature Medicine, 5: 431-433.