Research Seminar #14
September 18, 2013, 14h15-15h15
September 25, 2013, 14h15-15h15
Silvio A. B. Vieira de Melo
Supercritical fluid processes for the natural products extraction have been the focus of intensive research for more than 30 years and commercial plants are spread worldwide. More recently, new research interests have been growing on biomass, materials, pharmaceuticals and so on.
In this talking, some applications of supercritical fluids processing on the formation of pharmaceutical particles are presented. Some precipitation techniques are shown according to the role of the supercritical fluid in the process: Rapid Expansion of Supercritical Solutions (RESS), Gas Antisolvent (GAS), Supercritical AntiSolvent (SAS) and Particles from Gas-Saturated Solutions (PGSS). Three case studies are targeted to pharmaceutical nanoparticles formation and encapsulation in supercritical fluid medium for controlled drug delivery systems.