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Inflammation

Group leader: Anabela Mota Pinto

Core CVs: Ana Todo Bom and Lèlita Santos

Description:

Inflammation is an important clinical and research topic.

In oncology, it is recognized for its contribution to a favourable tumour microenvironment. New therapeutic initiatives in oncology has placed the immunological response of these patients at the centre of the attention of researchers and clinicians. Our group, in collaboration with several national and international research partners, is exploring technological tools to assess the immunological status of cancer patients, while optimizing new ways to use cells from the immune system for adoptive cell therapy.

Collaborations with clinical teams at CHUC and IPO in Coimbra have allowed the development of studies on non-small cell lung cancer), bone and soft tissue sarcomas, colon and rectum cancer, ductal adenocarcinoma of the pancreas, bladder carcinoma, chronic myeloid leukaemia and diffuse large B-cell.

Studies on cells (T, B, NK, dendritic and monocyte cells, innate Lymphoid Cells and myeloid-derived suppressor cells) and molecular mediators of inflammation, have been done by our group, not only at oncology research but also at allergy and cardiology disorders. Also,knowing that labor is accepted nowadays as an inflammatory event, a disting objective of this group work is the understanding of how modulation of inflammation can prevent preterm labor.

The laboratory hosts a Flow Cytometry and Cell Sorting Platform, a Molecular Immunology Unit, and culture rooms to use primary cells and cell lines. Next-Generation Sequencing (NGS), Luminex® (xMAP), Real-Time PCR, ELISPOT®, Automatic Nucleic Acid Extraction and various robots for automated tasks are also available.

Main achievements in the last 5 years:

Our major findings suggest the possibility of enhancing NK cell activity in cancer patients by using cytokines and immunomodulating agents. Also, after radiotherapy several signals can induce immune system against tumor cells. Treg cells together with MDSC contribute to tumor cell escape by inhibition of the immune system. PD-1, TIM-3 and CTLA-4 expression should be considered important biomarkers.

The study of allergic diseases multimorbidity in the elderly is also a main goal of our group, as well as the the understanding of how modulation of inflammation can prevent preterm labor.

Selected Publications in the last 5 years:

1. Bousquet J, Agache I, Aliberti MR, Angles R, Annesi-Maesano I, Anto JM, et al. Transfer of innovation on allergic rhinitis and asthma multimorbidity in the elderly (MACVIA-ARIA) - Reference Site Twinning (EIP on AHA). Allergy. 2018;73(1):77-92. doi: 10.1111/all.13218

IF: 6.048 (2017). Q1 (Allergy). Q1 (Immunology)

2. NCD Risk Factor Collaboration (NCD-RisC), Mota Pinto A. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. The Lancet. 2017;390(10113):2607-2608.

Lista de autores publicada em anexo, disponível em:

http://www.sciencedirect.com/science/article/pii/S0140673617321293?via%3Dihub#sec1.

DOI: 10.1016/S0140-6736(17)32129-3

IF: 53.254 (2017). Q1 (General & Internal Medicine)

3. Caimmi D, Baiz N, Tanno LK, Demoly P, Arnavielhe S, Murray R, (...) Mota Pinto A, Group., MASK S. Validation of the MASK-rhinitis visual analogue scale on smartphone screens to assess allergic rhinitis control. Clinical & Experimental Allergy 2017;47(12):1526-1533.

DOI: 10.1111/cea.13025

IF: 5.158 (2017). Q1 (Allergy). & Q1 (Immunology)

4. Areia A, Vale-Pereira S, Alves V, Rodrigues-Santos P, Santos-Rosa M, Moura P, Mota-Pinto A. Can membrane progesterone receptor α on T regulatory cells explain the ensuing human labour? J Reprod Immunol. 2016 Feb;113:22-6. doi:10.1016/j.jri.2015.10.002. Epub 2015 Oct 20. PubMed PMID: 26517007.

IF: 2.322 (2017). Q3 (Immunology) & Q3 (Reproductive Biology

5. Gradiz R, Silva HC, Carvalho L, Botelho MF, Mota-Pinto A. MIA PaCa-2 and PANC-1 – pancreas ductal adenocarcinoma cell lines with neuroendocrine differentiation and somatostatin receptors. Sci Reports. 2016;6(21648):1-14. doi: 10.1038/srep21648. 2016. PMID: 26884312

IF: 4.122(2017). Q1 (Multidisciplinary Sciences - Science & Technology - Other Topics).

6. Muc M, Mota-Pinto A, Padez C. Association between obesity and asthma - epidemiology, pathophysiology and clinical profile. Nutr Res Rev. 2016 Dec;29(2):194-201. Epub 2016 Aug 12. doi: 10.1017/S0954422416000111. PMID: 27514726

IF: 4.586 (2017) Q1 (Nutrition & Dietetics)

7. Areia A, Vale-Pereira S, Alves V, Rodrigues-Santos P, Moura P, Mota-Pinto A. Membrane progesterone receptors in human regulatory T cells: a reality in pregnancy. BJOG 2015;122(11):1544-1550. doi: 10.1111/1471-0528.13294

IF: 4.876 (2017): Q1 (Obstetrics & Gynecology)

8. Rodrigues-Santos P, López Sejas N, Almeida JS, Ruzičková L, Couceiro P, Alves V, Campos C, Alonso C, Tarazona R, Freitas-Tavares P, Solana R, Santos Rosa M. Effect of age on NK cell compartment in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors. Front Immunol 2018 (accepted).

IF: 5,511 (2017) Q1 (Immunology)

9. Ferreira-Teixeira M, Paiva-Oliveira D, Parada B, Alves V, Sousa V, Chijioke O, Münz C, Reis F, Gomes C, Rodrigues-Santos P. Natural killer cell-based adoptive immunotherapy eradicates and drives differentiation of chemoresistant bladder cancer stem-like cells. BMC Med. 2016 Oct 21;14(1):163. PubMed PMID: 27769244; PubMed Central PMCID: PMC5075212

IF: 7.901 (2016) Q1 (Medicine/miscellaneous)

10. Mendes F, Sales T, Domingues C, Schugk S, Abrantes AM, Gonçalves AC, Teixo R, Silva R, Casalta-Lopes J, Rocha C, Laranjo M, Simões PC, Ribeiro AB, Botelho MF, Rosa MS. Effects of X-radiation on lung cancer cells: the interplay between oxidative stress and P53 levels. Med Oncol. 2015

IF: 2,920 (2015) Q2 (Hematology, Medicine/miscellaneous)

People:

Integrated Members

Ana Areia, MD, PhD

Anabela Mota-Pinto, MD, PhD

Ana Todo Bom, MD, PhD

Celso Pereira, MD, PhD

Fernando Mendes, PhD

Francisco Portela, MD PhD

Helena Oliveira Sá, MD, PhD

Lèlita Santos, MD, PhD

Rui Alves, MD, PhD

Colaborators

Carlos Robalo Cordeiro, MD, PhD

Paulo Rodrigues Santos, MSc

Sónia Moreira, MD

Rui Gradiz, MD, PhD

PhD Sudents

Catarina Canha, MD

João Mendes, MSC

José Luís Alves