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DITS

Tecnologia

Process for preparing chlorins and their pharmaceutical uses

Publication date: 05-04-2012 11:12

Industria

Breve descrição

The invention provides the methods of preparation, properties, pharmaceutical compositions and methods of therapy of sulfonated chlorins and bacterioclorins designed for the photodynamic therapy (PDT) of hyperproliferative tissues such as tumors, hyperproliferative blood vessels and other disorders or abnormalies that are responsive to PDT. In particular, the economical large-scale synthesis of stable chlorins and bacteriochlorins is described. Their properties were tailored to meet those of ideal photosensitizers for PDT. In another embodiment, pharmaceutical compositions and methods of therapy for systemic administration are provided. In a further embodiment, pharmaceutical compositions and methods of therapy for topical administration are also provided.; Further provided is a method of labeling a target tissue and providing an image of that tissue by fluorescence of magnetic resonance imaging.

Propriedade intelectual

Patente nº WO2010046876
Data de prioridade 24-10-2008
Estado legal Pendente
Documento de patente 
Licenciamento