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IIIUC

Instituto de Investigação Interdisciplinar

Pharmacology & Toxicology (47)

Title : A thermodynamic based approach on the investigation of a diflunisal pharmaceutical co-crystal with improved intrinsic dissolution rate
Author(s): Evora, AOL; Castro, RAE; Maria, TMR; Silva, MR; ter Horst, JH; Canotilho, J; Eusebio, MES
Source : INTERNATIONAL JOURNAL OF PHARMACEUTICS Document Type : Article Volume : 466 Issue: 1-2 Pages: 68-75 DOI: 10.1016/j.ijpharm.2014.02.048 Published: 2014 MAY 15
Times Cited: 10
 
Title : Advance in Methods Studying the Pharmacokinetics of Polyphenols
Author(s): Santos, AC; Costa, G; Veiga, F; Figueiredo, IV; Batista, MT; Ribeiro, AJ
Source : CURRENT DRUG METABOLISM Document Type : Article Volume : 15 Issue: 1 Pages: 96-115 DOI: Published: 2014 JAN
Times Cited: 1
 
Title : Application of Thermoresponsive PNIPAAM-b-PAMPTMA Diblock Copolymers in siRNA Delivery
Author(s): Cardoso, AM; Calejo, MT; Morais, CM; Cardoso, AL; Cruz, R; Zhu, KZ; de Lima, MCP; Jurado, AS; Nystrom, B
Source : MOLECULAR PHARMACEUTICS Document Type : Article Volume : 11 Issue: 3 Pages: 819-827 DOI: 10.1021/mp400510a Published: 2014 MAR
Times Cited: 4
 
Title : Assessing the impact of multi-compartment compliance aids on clinical outcomes in the elderly: a pilot study
Author(s): Mosca, C; Castel-Branco, MM; Ribeiro-Rama, AC; Caramona, MM; Fernandez-Llimos, F; Figueiredo, IV
Source : INTERNATIONAL JOURNAL OF CLINICAL PHARMACY Document Type : Article Volume : 36 Issue: 1 Pages: 98-104 DOI: 10.1007/s11096-013-9852-2 Published: 2014 FEB
Times Cited: 5
 
Title : Atorvastatin-mediated protection of the retina in a model of diabetes with hyperlipidemia
Author(s): Fernandes, R; Bento, CF; Matafome, P; Sena, CM; Seica, RM; Pereira, P
Source : CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY Document Type : Article Volume : 92 Issue: 12 Pages: 1037-1043 DOI: 10.1139/cjpp-2014-0212 Published: 2014 DEC
Times Cited: 3
 
Title : beta-Adrenergic Over-Stimulation and Cardio-Myocyte Apoptosis: Two Receptors, One Organelle, Two Fates?
Author(s): Branco, AF; Moreira, AC; Cunha-Oliveira, T; Couto, R; Sardao, VA; Rizvanov, AA; Palotas, A; Oliveira, PJ
Source : CURRENT DRUG TARGETS Document Type : Article Volume : 15 Issue: 10 Pages: 956-964 DOI: 10.2174/1389450115666140902124230 Published: 2014
Times Cited: 0
 
Title : Beyond Overton's Rule: Quantitative Modeling of Passive Permeation through Tight Cell Monolayers
Author(s): Filipe, HAL; Salvador, A; Silvestre, JM; Vaz, WLC; Moreno, MJ
Source : MOLECULAR PHARMACEUTICS Document Type : Article Volume : 11 Issue: 10 Pages: 3696-3706 DOI: 10.1021/mp500437e Published: 2014 OCT
Times Cited: 5
 
Title : Bioactivity of Fragaria vesca leaves through inflammation, proteasome and autophagy modulation
Author(s): Liberal, J; Francisco, V; Costa, G; Figueirinha, A; Amaral, MT; Marques, C; Girao, H; Lopes, MC; Cruz, MT; Batista, MT
Source : JOURNAL OF ETHNOPHARMACOLOGY Document Type : Article Volume : 158 Issue: Pages: 113-122 DOI: 10.1016/j.jep.2014.09.043 Published: 2014 DEC 2
Times Cited: 3
 
Title : Biomarkers of mitochondrial dysfunction and toxicity
Author(s): Palmeira, CM; Duarte, FV; Teodoro, JS; Varela, AT; Rolo, AP
Source : BIOMARKERS IN TOXICOLOGY Document Type : Article; Book Chapter Volume : Issue: Pages: 847-861 DOI: 10.1016/B978-0-12-404630-6.00051-8 Published: 2014
Times Cited: 0
 
Title : Bis-quaternary gemini surfactants as components of nonviral gene delivery systems: A comprehensive study from physicochemical properties to membrane interactions
Author(s): Cardoso, AM; Morais, CM; Silva, SG; Marques, EF; de Lima, MCP; Jurado, MAS
Source : INTERNATIONAL JOURNAL OF PHARMACEUTICS Document Type : Article Volume : 474 Issue: 1-2 Pages: 57-69 DOI: 10.1016/j.ijpharm.2014.08.011 Published: 2014 OCT 20
Times Cited: 14
 
Title : Can Tea Consumption be a Safe and Effective Therapy Against Diabetes Mellitus-Induced Neurodegeneration?
Author(s): Nunes, AR; Alves, MG; Moreira, PI; Oliveira, PF; Silva, BM
Source : CURRENT NEUROPHARMACOLOGY Document Type : Article Volume : 12 Issue: 6 Pages: 475-489 DOI: Published: 2014
Times Cited: 5
 
Title : Cumulative Mitoxantrone-Induced Haematological and Hepatic Adverse Effects in a Subchronic In vivo Study
Author(s): Rossato, LG; Costa, VM; Dallegrave, E; Arbo, M; Dinis-Oliveira, RJ; Santos-Silva, A; Duarte, JA; Bastos, MD; Palmeira, C; Remiao, F
Source : BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY Document Type : Article Volume : 114 Issue: 3 Pages: 254-262 DOI: 10.1111/bcpt.12143 Published: 2014 MAR
Times Cited: 3
 
Title : Current Therapeutic Advances in Patients and Experimental Models of Huntington's Disease
Author(s): Brett, AC; Rosenstock, TR; Rego, AC
Source : CURRENT DRUG TARGETS Document Type : Article Volume : 15 Issue: 3 Pages: 313-334 DOI: Published: 2014 MAR
Times Cited: 7
 
Title : Cyclosporine A enhances gluconeogenesis while sirolimus impairs insulin signaling in peripheral tissues after 3 weeks of treatment
Author(s): Lopes, PC; Fuhrmann, A; Carvalho, F; Sereno, J; Santos, MR; Pereira, MJ; Eriksson, JW; Reis, F; Carvalho, E
Source : BIOCHEMICAL PHARMACOLOGY Document Type : Article Volume : 91 Issue: 1 Pages: 61-73 DOI: 10.1016/j.bcp.2014.06.014 Published: 2014 SEP 1
Times Cited: 5
 
Title : Determination of preferred conformations of ibuprofen in chloroform by 2D NOE spectroscopy
Author(s): Khodov, IA; Efimov, SV; Klochkov, VV; Alper, GA; de Carvalho, LAEB
Source : EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES Document Type : Article Volume : 65 Issue: Pages: 65-73 DOI: 10.1016/j.ejps.2014.08.005 Published: 2014 DEC 18
Times Cited: 6
 
Title : Effect of Cyclodextrins and pH on the permeation of tetracaine: Supramolecular assemblies and release behavior
Author(s): Teixeira, RS; Veiga, FJB; Oliveira, RS; Jones, SA; Silva, SMC; Carvalho, RA; Valente, AJM
Source : INTERNATIONAL JOURNAL OF PHARMACEUTICS Document Type : Article Volume : 466 Issue: 1-2 Pages: 349-358 DOI: 10.1016/j.ijpharm.2014.03.035 Published: 2014 MAY 15
Times Cited: 8
 
Title : Endothelial progenitor cells in diabetic patients with myocardial infarction - Can statins improve their function?
Author(s): Antonio, N; Soares, A; Fernandes, R; Soares, F; Lopes, A; Carvalheiro, T; Paiva, A; Providencia, LA; Goncalves, L; Ribeiro, CF
Source : EUROPEAN JOURNAL OF PHARMACOLOGY Document Type : Article Volume : 741 Issue: Pages: 25-36 DOI: 10.1016/j.ejphar.2014.07.010 Published: 2014 OCT 15
Times Cited: 6
 
Title : Exuberant connubial allergic contact dermatitis from diphenhydramine
Author(s): Teixeira, V; Cabral, R; Goncalo, M
Source : CUTANEOUS AND OCULAR TOXICOLOGY Document Type : Article Volume : 33 Issue: 1 Pages: 82-84 DOI: 10.3109/15569527.2013.812106 Published: 2014 MAR
Times Cited: 1
 
Title : HepaRG cell line as an in vitro model for screening drug-drug interactions mediated by metabolic induction: Amiodarone used as a model substance
Author(s): Ferreira, A; Rodrigues, M; Silvestre, S; Falcao, A; Alves, G
Source : TOXICOLOGY IN VITRO Document Type : Article Volume : 28 Issue: 8 Pages: 1531-1535 DOI: 10.1016/j.tiv.2014.08.004 Published: 2014 DEC
Times Cited: 2
 
Title : Highlights of Pentacyclic Triterpenoids in the Cancer Settings
Author(s): Salvador, JAR; Leal, AS; Alho, DPS; Goncalves, BMF; Valdeira, AS; Mendes, VIS; Jing, YK
Source : STUDIES IN NATURAL PRODUCTS CHEMISTRY, VOL 41 Document Type : Article; Book Chapter Volume : 41 Issue: Pages: 33-73 DOI: 10.1016/B978-0-444-63294-4.00002-4 Published: 2014
Times Cited: 12
 
Title : Improving discrimination in the grading of rat mammary tumors using two-dimensional mapping of histopathological observations
Author(s): Lopes, AC; Cova, TFGG; Pais, AACC; Pereira, JLGFSC; Colaco, B; Cabrita, AMS
Source : EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY Document Type : Article Volume : 66 Issue: 1 Pages: 73-80 DOI: 10.1016/j.etp.2013.09.001 Published: 2014 JAN
Times Cited: 1
 
Title : Interaction of Fullerene Nanoparticles With Biomembranes: From the Partition in Lipid Membranes to Effects on Mitochondrial Bioenergetics
Author(s): Santos, SM; Dinis, AM; Peixoto, F; Ferreira, L; Jurado, AS; Videira, RA
Source : TOXICOLOGICAL SCIENCES Document Type : Article Volume : 138 Issue: 1 Pages: 117-129 DOI: 10.1093/toxsci/kft327 Published: 2014 MAR
Times Cited: 14
 
Title : Intestinal Uptake of Insulin Nanoparticles: Facts or Myths?
Author(s): Lopes, MA; Abrahim, BA; Seica, R; Veiga, F; Rodrigues, CR; Ribeiro, AJ
Source : CURRENT PHARMACEUTICAL BIOTECHNOLOGY Document Type : Article Volume : 15 Issue: 7 Pages: 629-638 DOI: Published: 2014
Times Cited: 4
 
Title : Intranasal administration of carbamazepine to mice: A direct delivery pathway for brain targeting
Author(s): Serralheiro, A; Alves, G; Fortuna, A; Falcao, A
Source : EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES Document Type : Article Volume : 60 Issue: Pages: 32-39 DOI: 10.1016/j.ejps.2014.04.019 Published: 2014 AUG 18
Times Cited: 16
 
Title : Lysine acetylsalicylate improves the safety of paraquat formulation in rats by increasing its elimination and preventing lung and kidney injury
Author(s): Baltazar, MT; Dinis-Oliveira, RJ; Bastos, MD; Duarte, JA; Carvalho, F
Source : TOXICOLOGY RESEARCH Document Type : Article Volume : 3 Issue: 4 Pages: 266-277 DOI: 10.1039/c3tx50102g Published: 2014
Times Cited: 1
 
Title : Lysine-based surfactants as chemical permeation enhancers for dermal delivery of local anesthetics
Author(s): Teixeira, RS; Cova, TFGG; Silva, SMC; Oliveira, R; Araujo, MJ; Marques, EF; Pais, AACC; Veiga, FJB
Source : INTERNATIONAL JOURNAL OF PHARMACEUTICS Document Type : Article Volume : 474 Issue: 1-2 Pages: 212-222 DOI: 10.1016/j.ijpharm.2014.08.002 Published: 2014 OCT 20
Times Cited: 7
 
Title : Metformin and male reproduction: effects on Sertoli cell metabolism
Author(s): Alves, MG; Martins, AD; Vaz, CV; Correia, S; Moreira, PI; Oliveira, PF; Socorro, S
Source : BRITISH JOURNAL OF PHARMACOLOGY Document Type : Article Volume : 171 Issue: 4 Pages: 1033-1042 DOI: 10.1111/bph.12522 Published: 2014 FEB
Times Cited: 22
 
Title : Mitochondrial Cumulative Damage Induced by Mitoxantrone: Late Onset Cardiac Energetic Impairment
Author(s): Rossato, LG; Costa, VM; Dallegrave, E; Arbo, M; Silva, R; Ferreira, R; Amado, F; Dinis-Oliveira, RJ; Duarte, JA; Bastos, MD; Palmeira, C; Remiao, F
Source : CARDIOVASCULAR TOXICOLOGY Document Type : Article Volume : 14 Issue: 1 Pages: 30-40 DOI: 10.1007/s12012-013-9230-2 Published: 2014 MAR
Times Cited: 8
 
Title : Mitochondrial Membrane Lipids in Life and Death and their Molecular Modulation by Diet: Tuning the Furnace
Author(s): Monteiro, JP; Morais, CM; Oliveira, PJ; Jurado, AS
Source : CURRENT DRUG TARGETS Document Type : Article Volume : 15 Issue: 8 Pages: 797-810 DOI: Published: 2014
Times Cited: 3
 
Title : Modulation of Biodistribution, Pharmacokinetics, and Photosensitivity with the Delivery Vehicle of a Bacteriochlorin Photosensitizer for Photodynamic Therapy
Author(s): Saavedra, R; Rocha, LB; Dabrowski, JM; Arnaut, LG
Source : CHEMMEDCHEM Document Type : Article Volume : 9 Issue: 2 Pages: 390-398 DOI: 10.1002/cmdc.201300449 Published: 2014 FEB
Times Cited: 21
 
Title : Molecular mechanisms underlying the effects of cyclosporin A and sirolimus on glucose and lipid metabolism in liver, skeletal muscle and adipose tissue in an in vivo rat model
Author(s): Fuhrmann, A; Lopes, PC; Sereno, J; Pedro, J; Espinoza, DO; Pereira, MJ; Reis, F; Eriksson, JW; Carvalho, E
Source : BIOCHEMICAL PHARMACOLOGY Document Type : Article Volume : 88 Issue: 2 Pages: 216-228 DOI: 10.1016/j.bcp.2014.01.020 Published: 2014 MAR 15
Times Cited: 13
 
Title : Multi-method Active Learning Approach: improving the educational experience in Pharmaceutical Drug Development
Author(s): Herdeiro, MT; Rodrigues, TA; Ferreira, M; e Silva, ABD; Fardilha, M
Source : INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH Document Type : Article Volume : 48 Issue: 3 Pages: 16-25 DOI: 10.5530/ijper.48.3.4 Published: 2014 JUL-SEP
Times Cited: 1
 
Title : N-diethylnitrosamine mouse hepatotoxicity: Time-related effects on histology and oxidative stress
Author(s): Santos, NP; Colaco, A; da Costa, RMG; Oliveira, MM; Peixoto, F; Oliveira, PA
Source : EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY Document Type : Article Volume : 66 Issue: 9-10 Pages: 429-436 DOI: 10.1016/j.etp.2014.07.002 Published: 2014 DEC
Times Cited: 10
 
Title : New drug-eluting lenses to be applied as bandages after keratoprosthesis implantation
Author(s): Carreira, AS; Ferreira, P; Ribeiro, MP; Correia, TR; Coutinho, P; Correia, IJ; Gil, MH
Source : INTERNATIONAL JOURNAL OF PHARMACEUTICS Document Type : Article Volume : 477 Issue: 1-2 Pages: 218-226 DOI: 10.1016/j.ijpharm.2014.10.037 Published: 2014 DEC 30
Times Cited: 4
 
Title : Passive and active strategies for transdermal delivery using co-encapsulating nanostructured lipid carriers: In vitro vs. in vivo studies
Author(s): Vitorino, C; Almeida, A; Sousa, J; Lamarche, I; Gobin, P; Marchand, S; Couet, W; Olivier, JC; Pais, A
Source : EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS Document Type : Article Volume : 86 Issue: 2 Pages: 133-144 DOI: 10.1016/j.ejpb.2013.12.004 Published: 2014 FEB
Times Cited: 20
 
Title : Pd/C-mediated Synthesis of 3-methyleneisoindolin-1-ones: Biological and Theoretical Study of their PDE4 Inhibition
Author(s): Vijayavardhini, S; Rambabu, D; Anuradha, V; Kapavarapu, R; Rao, MVB; Pal, M
Source : LETTERS IN DRUG DESIGN & DISCOVERY Document Type : Article Volume : 11 Issue: 10 Pages: 1188-1198 DOI: Published: 2014
Times Cited: 0
 
Title : PLGA nanoparticles loaded with host defense peptide LL37 promote wound healing
Author(s): Chereddy, KK; Her, CH; Comune, M; Moia, C; Lopes, A; Porporato, PE; Vanacker, J; Lam, MC; Steinstraesser, L; Sonveaux, P; Zhu, HJ; Ferreira, LS; Vandermeulen, G; Preat, V
Source : JOURNAL OF CONTROLLED RELEASE Document Type : Article Volume : 194 Issue: Pages: 138-147 DOI: 10.1016/j.jconrel.2014.08.016 Published: 2014 NOV 28
Times Cited: 28
 
Title : Preparation of Supramolecular Hydrogels Containing Poloxamers and Methyl-beta-cyclodextrin
Author(s): Garcia, MJ; Ruivo, J; Oliveira, R; Figueiras, A
Source : LETTERS IN DRUG DESIGN & DISCOVERY Document Type : Article Volume : 11 Issue: 7 Pages: 922-929 DOI: Published: 2014
Times Cited: 2
 
Title : Prospection, Collection, and Preservation of Marine Samples
Author(s): Leston, S; Nunes, M; Rosa, J; Lemos, MFL; Ramos, F; Pardal, MA
Source : ANALYSIS OF MARINE SAMPLES IN SEARCH OF BIOACTIVE COMPOUNDS Document Type : Article; Book Chapter Volume : 65 Issue: Pages: 15-34 DOI: 10.1016/B978-0-444-63359-0.00002-1 Published: 2014
Times Cited: 0
 
Title : Screening and identification of neuroprotective compounds relevant to Alzheimer's disease from medicinal plants of S. Tome e Principe
Author(s): Currais, A; Chiruta, C; Goujon-Svrzic, M; Costa, G; Santos, T; Batista, MT; Paiva, J; Madureira, MD; Maher, P
Source : JOURNAL OF ETHNOPHARMACOLOGY Document Type : Article Volume : 155 Issue: 1 Pages: 830-840 DOI: 10.1016/j.jep.2014.06.046 Published: 2014 AUG 8
Times Cited: 9
 
Title : Simultaneous active intracellular delivery of doxorubicin and C6-ceramide shifts the additive/antagonistic drug interaction of non-encapsulated combination
Author(s): Fonseca, NA; Gomes-da-Silva, LC; Moura, V; Simoes, S; Moreira, JN
Source : JOURNAL OF CONTROLLED RELEASE Document Type : Article Volume : 196 Issue: Pages: 122-131 DOI: 10.1016/j.jconrel.2014.09.024 Published: 2014 DEC 28
Times Cited: 7
 
Title : Specific and efficient gene delivery mediated by an asialofetuin-associated nanosystem
Author(s): Farinha, D; de Lima, MCP; Faneca, H
Source : INTERNATIONAL JOURNAL OF PHARMACEUTICS Document Type : Article Volume : 473 Issue: 1-2 Pages: 366-374 DOI: 10.1016/j.ijpharm.2014.07.019 Published: 2014 OCT 1
Times Cited: 2
 
Title : Spermicidal and Microbicidal Compounds: In Search of an Efficient Multipurpose Strategy
Author(s): Baptista, M; Tavares, R; Ramalho-Santos, J
Source : CURRENT MEDICINAL CHEMISTRY Document Type : Article Volume : 21 Issue: 32 Pages: 3693-3700 DOI: Published: 2014
Times Cited: 1
 
Title : Supramolecular gels of poly-alpha-cyclodextrin and PEO-based copolymers for controlled drug release
Author(s): Simoes, SMN; Veiga, F; Ribeiro, ACF; Figueiras, AR; Taboada, P; Concheiro, A; Alvarez-Lorenzo, C
Source : EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS Document Type : Article Volume : 87 Issue: 3 Pages: 579-588 DOI: 10.1016/j.ejpb.2014.04.006 Published: 2014 AUG
Times Cited: 14
 
Title : Sustained Release of Naltrexone from Poly(N-Isopropylacrylamide) Microgels
Author(s): Kjoniksen, AL; Calejo, MT; Zhu, KZ; Cardoso, AMS; de Lima, MCP; Jurado, AS; Nystrom, B; Sande, SA
Source : JOURNAL OF PHARMACEUTICAL SCIENCES Document Type : Article Volume : 103 Issue: 1 Pages: 227-234 DOI: 10.1002/jps.23780 Published: 2014 JAN
Times Cited: 3
 
Title : The Influence of Drug Physical State on the Dissolution Enhancement of Solid Dispersions Prepared Via Hot-Melt Extrusion: A Case Study Using Olanzapine
Author(s): Pina, MF; Zhao, M; Pinto, JF; Sousa, JJ; Craig, DQM
Source : JOURNAL OF PHARMACEUTICAL SCIENCES Document Type : Article Volume : 103 Issue: 4 Pages: 1214-1223 DOI: 10.1002/jps.23894 Published: 2014 APR
Times Cited: 16
 
Title : Toxicity of the herbicide linuron as assessed by bacterial and mitochondrial model systems
Author(s): Santos, SMA; Videira, RA; Fernandes, MAS; Santos, MS; Moreno, AJM; Vicente, JAF; Jurado, AS
Source : TOXICOLOGY IN VITRO Document Type : Article Volume : 28 Issue: 5 Pages: 932-939 DOI: 10.1016/j.tiv.2014.04.004 Published: 2014 AUG
Times Cited: 5