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IIIUC

Instituto de Investigação Interdisciplinar

Pharmacology & Toxicology (44)

Title : A fast and reliable method for GHB quantitation in whole blood by GC-MS/MS (TQD) for forensic purposes
Author(s): Castro, AL; Tarelho, S; Dias, M; Reis, F; Teixeira, HM
Source : JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS Document Type : Article Volume : 119 Issue: Pages: 139-144 DOI: 10.1016/j.jpba.2015.11.038 Published: 2016 FEB 5
Times Cited: 1
 
Title : A new PAMPA model using an in-house brain lipid extract for screening the blood-brain barrier permeability of drug candidates
Author(s): Bicker, J; Alves, G; Fortuna, A; Soares-da-Silva, P; Falcao, A
Source : INTERNATIONAL JOURNAL OF PHARMACEUTICS Document Type : Article Volume : 501 Issue: 1-2 Pages: 102-111 DOI: 10.1016/j.ijpharm.2016.01.074 Published: 2016 MAR 30
Times Cited: 3
 
Title : Adenosine diphosphate involvement in THP-1 maturation triggered by the contact allergen 1-fluoro-2,4-dinitrobenzene
Author(s): Martins, JD; Silva, A; Ferreira, I; Goncalo, M; Custodio, JBA; Lopes, MC; Domingues, MRM; Neves, BM; Cruz, MT
Source : TOXICOLOGY RESEARCH Document Type : Article Volume : 5 Issue: 6 Pages: 1512-1521 DOI: 10.1039/c6tx00240d Published: 2016
Times Cited: 0
 
Title : Anti-inflammatory protection afforded by cyanidin-3-glucoside and resveratrol in human intestinal cells via Nrf2 and PPAR-gamma: Comparison with 5-aminosalicylic acid
Author(s): Serra, D; Almeida, LM; Dinis, TCP
Source : CHEMICO-BIOLOGICAL INTERACTIONS Document Type : Article Volume : 260 Issue: Pages: 102-109 DOI: 10.1016/j.cbi.2016.11.003 Published: 2016 DEC 25
Times Cited: 1
 
Title : Antidepressants detection and quantification in whole blood samples by GC-MS/MS, for forensic purposes
Author(s): Truta, L; Castro, AL; Tarelho, S; Costa, P; Sales, MGF; Teixeira, HM
Source : JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS Document Type : Article Volume : 128 Issue: Pages: 496-503 DOI: 10.1016/j.jpba.2016.06.027 Published: 2016 SEP 5
Times Cited: 0
 
Title : Biopharmaceutical evaluation of epigallocatechin gallate-loaded cationic lipid nanoparticles (EGCG-LNs): In vivo,in vitro and ex vivo studies
Author(s): Fangueiro, JF; Calpena, AC; Clares, B; Andreani, T; Egea, MA; Veiga, FJ; Garcia, ML; Silva, AM; Souto, EB
Source : INTERNATIONAL JOURNAL OF PHARMACEUTICS Document Type : Article Volume : 502 Issue: 1-2 Pages: 161-169 DOI: 10.1016/j.ijpharm.2016.02.039 Published: 2016 APR 11
Times Cited: 6
 
Title : Biopharmaceutical profile of hydrogels containing pranoprofen-loaded PLGA nanoparticles for skin administration: In vitro, ex vivo and in vivo characterization
Author(s): Abrego, G; Alvarado, H; Souto, EB; Guevara, B; Bellowa, LH; Garduno, ML; Garcia, ML; Calpena, AC
Source : INTERNATIONAL JOURNAL OF PHARMACEUTICS Document Type : Article Volume : 501 Issue: 1-2 Pages: 350-361 DOI: 10.1016/j.ijpharm.2016.01.071 Published: 2016 MAR 30
Times Cited: 2
 
Title : Can lipid nanoparticles improve intestinal absorption?
Author(s): Mendes, M; Soares, HT; Arnaut, LG; Sousa, JJ; Pais, AACC; Vitorino, C
Source : INTERNATIONAL JOURNAL OF PHARMACEUTICS Document Type : Article Volume : 515 Issue: 1-2 Pages: 69-83 DOI: 10.1016/j.ijpharm.2016.09.065 Published: 2016 DEC 30
Times Cited: 0
 
Title : Chemical composition and biological activities of Artemisia judaica essential oil from southern desert of Jordan
Author(s): Abu-Darwish, MS; Cabral, C; Goncalves, MJ; Cavaleiro, C; Cruz, MT; Zulfiqar, A; Khan, IA; Efferth, T; Salgueiro, L
Source : JOURNAL OF ETHNOPHARMACOLOGY Document Type : Article Volume : 191 Issue: Pages: 161-168 DOI: 10.1016/j.jep.2016.06.023 Published: 2016 SEP 15
Times Cited: 0
 
Title : Contractile effects of 3,4-methylenedioxymethamphetamine on the human internal mammary artery
Author(s): Silva, S; Carvalho, F; Fernandes, E; Antunes, MJ; Cotrim, MD
Source : TOXICOLOGY IN VITRO Document Type : Article Volume : 34 Issue: Pages: 187-193 DOI: 10.1016/j.tiv.2016.04.002 Published: 2016 AUG
Times Cited: 0
 
Title : Development and application of an ex vivo fosphenytoin nasal bioconversion/permeability evaluation method
Author(s): Viegas, DA; Rodrigues, M; Francisco, J; Falcao, A; Alves, G; Santos, AO
Source : EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES Document Type : Article Volume : 89 Issue: Pages: 61-72 DOI: 10.1016/j.ejps.2016.04.018 Published: 2016 JUN 30
Times Cited: 1
 
Title : Development and Validation of a New Method to Quantify Pilocarpine in Tablets by HPLC-DAD
Author(s): Moreira, DD; Ribeiro, S; Ribeiro, AJ; Veiga, FB; Sobrinho, JLS; da Silva, EC; de Sa, LLF; de Freitas, RM; Nunes, LCC
Source : CURRENT PHARMACEUTICAL ANALYSIS Document Type : Article Volume : 12 Issue: 4 Pages: 315-324 DOI: 10.2174/1573412912666151111222510 Published: 2016
Times Cited: 0
 
Title : Diclofenac-beta-cyclodextrin for colonic drug targeting: In vivo performance in rats
Author(s): Vieira, ACF; Serra, AC; Veiga, FJ; Gonsalves, AMD; Basit, AW; Murdan, S
Source : INTERNATIONAL JOURNAL OF PHARMACEUTICS Document Type : Article Volume : 500 Issue: 1-2 Pages: 366-370 DOI: 10.1016/j.ijpharm.2016.01.024 Published: 2016 MAR 16
Times Cited: 0
 
Title : Dual chitosan/albumin-coated alginate/dextran sulfate nanoparticles for enhanced oral delivery of insulin
Author(s): Lopes, M; Shrestha, N; Correia, A; Shahbazi, MA; Sarmento, B; Hirvonen, J; Veiga, F; Seica, R; Ribeiro, A; Santos, HA
Source : JOURNAL OF CONTROLLED RELEASE Document Type : Article Volume : 232 Issue: Pages: 29-41 DOI: 10.1016/j.jconrel.2016.04.012 Published: 2016 JUN 28
Times Cited: 6
 
Title : Effect of 3 Single-Dose Regimens of Opicapone on Levodopa Pharmacokinetics, Catechol-O-Methyltransferase Activity and Motor Response in Patients With Parkinson Disease
Author(s): Rocha, JF; Ferreira, JJ; Falcao, A; Santos, A; Pinto, R; Nunes, T; Almeida, L; Soares-da-Silva, P
Source : CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT Document Type : Article Volume : 5 Issue: 3 Pages: 232-240 DOI: 10.1002/cpdd.217 Published: 2016 MAY-JUN
Times Cited: 4
 
Title : Enhancing glioblastoma cell sensitivity to chemotherapeutics: A strategy involving survivin gene silencing mediated by gemini surfactant-based complexes
Author(s): Cruz, RQ; Morais, CM; Cardoso, AM; Silva, SG; Vale, ML; Marques, EF; de Lima, MCP; Jurado, AS
Source : EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS Document Type : Article Volume : 104 Issue: Pages: 7-18 DOI: 10.1016/j.ejpb.2016.04.014 Published: 2016 JUL
Times Cited: 0
 
Title : Evaluation of Polybrominated Diphenyl Ether Toxicity on HepG2 Cells - Hexabrominated Congener (BDE-154) Is Less Toxic than Tetrabrominated Congener (BDE-47)
Author(s): Souza, AO; Tasso, MJ; Oliveira, AMC; Pereira, LC; Duarte, FV; Oliveira, DP; Palmeira, CM; Dorta, DJ
Source : BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY Document Type : Article Volume : 119 Issue: 5 Pages: 485-497 DOI: 10.1111/bcpt.12598 Published: 2016 NOV
Times Cited: 0
 
Title : Hepatic and skeletal muscle mitochondrial toxicity of chitosan oligosaccharides of normal and diabetic rats
Author(s): Teodoro, JS; Gomes, AP; Varela, AT; Duarte, FV; Rolo, AP; Palmeira, CM
Source : TOXICOLOGY MECHANISMS AND METHODS Document Type : Article Volume : 26 Issue: 9 Pages: 650-657 DOI: 10.1080/15376516.2016.1222643 Published: 2016 NOV
Times Cited: 0
 
Title : Hydrophobic polymers for orodispersible films: a quality by design approach
Author(s): Borges, AF; Silva, BMA; Silva, C; Coelho, JFJ; Simoes, S
Source : EXPERT OPINION ON DRUG DELIVERY Document Type : Article Volume : 13 Issue: 10 Pages: 1357-1374 DOI: 10.1080/17425247.2016.1218458 Published: 2016 OCT
Times Cited: 0
 
Title : Immune response elicited by an intranasally delivered HBsAg low-dose adsorbed to poly-epsilon-caprolactone based nanoparticles
Author(s): Jesus, S; Soares, E; Costa, J; Borchard, G; Borges, O
Source : INTERNATIONAL JOURNAL OF PHARMACEUTICS Document Type : Article Volume : 504 Issue: 1-2 Pages: 59-69 DOI: 10.1016/j.ijpharm.2016.03.013 Published: 2016 MAY 17
Times Cited: 2
 
Title : Immunomodulatory/inflammatory effects of geopropolis produced by Melipona fasciculata Smith in combination with doxorubicin on THP-1 cells
Author(s): Oliveira, LPG; Conte, FL; Cardoso, ED; Conti, BJ; Santiago, KB; Golim, MD; Cruz, MT; Sforcin, JM
Source : JOURNAL OF PHARMACY AND PHARMACOLOGY Document Type : Article Volume : 68 Issue: 12 Pages: 1551-1558 DOI: 10.1111/jphp.12649 Published: 2016 DEC
Times Cited: 0
 
Title : In vitro, ex vivo and in vivo characterization of PLGA nanoparticles loading pranoprofen for ocular administration
Author(s): Canadas, C; Alvarado, H; Calpena, AC; Silva, AM; Souto, EB; Garcia, ML; Abrego, G
Source : INTERNATIONAL JOURNAL OF PHARMACEUTICS Document Type : Article Volume : 511 Issue: 2 Pages: 719-727 DOI: 10.1016/j.ijpharm.2016.07.055 Published: 2016 SEP 25
Times Cited: 0
 
Title : Intranasal Administration of Novel Chitosan Nanoparticle/DNA Complexes Induces Antibody Response to Hepatitis B Surface Antigen in Mice
Author(s): Lebre, F; Borchard, G; Faneca, H; de Lima, MCP; Borges, O
Source : MOLECULAR PHARMACEUTICS Document Type : Article Volume : 13 Issue: 2 Pages: 472-482 DOI: 10.1021/acs.molpharmaceut.5b00707 Published: 2016 FEB
Times Cited: 6
 
Title : Long term performance evaluation of small-diameter vascular grafts based on polyvinyl alcohol hydrogel and dextran and MSCs-based therapies using the ovine pre-clinical animal model
Author(s): Alexandre, N; Amorim, I; Caseiro, AR; Pereira, T; Alvites, R; Rema, A; Goncalves, A; Valadares, G; Costa, E; Santos-Silva, A; Rodrigues, M; Lopes, MA; Almeida, A; Santos, JD; Mauricio, AC; Luis, AL
Source : INTERNATIONAL JOURNAL OF PHARMACEUTICS Document Type : Article Volume : 513 Issue: 1-2 Pages: 332-346 DOI: 10.1016/j.ijpharm.2016.09.045 Published: 2016 NOV 20
Times Cited: 0
 
Title : Long-term exercise training as a modulator of mammary cancer vascularization
Author(s): Faustino-Rocha, AI; Silva, A; Gabriel, J; da Costa, RMG; Moutinho, M; Oliveira, PA; Gama, A; Ferreira, R; Ginja, M
Source : BIOMEDICINE & PHARMACOTHERAPY Document Type : Article Volume : 81 Issue: Pages: 273-280 DOI: 10.1016/j.biopha.2016.04.030 Published: 2016 JUL
Times Cited: 2
 
Title : Mechanisms by which the thiazolidinedione troglitazone protects against sucrose-induced hepatic fat accumulation and hyperinsulinaemia
Author(s): Martins, FO; Delgado, TC; Viegas, J; Gaspar, JM; Scott, DK; O'Doherty, RM; Macedo, MP; Jones, JG
Source : BRITISH JOURNAL OF PHARMACOLOGY Document Type : Article Volume : 173 Issue: 2 Pages: 267-278 DOI: 10.1111/bph.13362 Published: 2016 JAN
Times Cited: 0
 
Title : Microarray Evaluation of Antimicrobial Resistance and Virulence of Escherichia coli Isolates from Portuguese Poultry
Author(s): Mendonca, N; Figueiredo, R; Mendes, C; Card, RM; Anjum, MF; da Silva, GJ
Source : ANTIBIOTICS-BASEL Document Type : Article Volume : 5 Issue: 1 Pages: - DOI: 10.3390/antibiotics5010004 Published: 2016 MAR
Times Cited: 1
 
Title : MicroRNA-124 loaded nanoparticles enhance brain repair in Parkinson's disease
Author(s): Saraiva, C; Paiva, J; Santos, T; Ferreira, L; Bernardino, L
Source : JOURNAL OF CONTROLLED RELEASE Document Type : Article Volume : 235 Issue: Pages: 291-305 DOI: 10.1016/j.jconrel.2016.06.005 Published: 2016 AUG 10
Times Cited: 2
 
Title : Ocular Drug Delivery - New Strategies for Targeting Anterior and Posterior Segments of the Eye
Author(s): Fangueiro, JF; Veiga, F; Silva, AM; Souto, EB
Source : CURRENT PHARMACEUTICAL DESIGN Document Type : Article Volume : 22 Issue: 9 Pages: 1135-1146 DOI: 10.2174/1381612822666151216145900 Published: 2016
Times Cited: 5
 
Title : Opicapone pharmacokinetics and pharmacodynamics comparison between healthy Japanese and matched white subjects
Author(s): Falcao, A; Rocha, JF; Santos, A; Nunes, T; Soares-da-Silva, P
Source : CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT Document Type : Article Volume : 5 Issue: 2 Pages: 150-161 DOI: 10.1002/cpdd.213 Published: 2016 MAR-APR
Times Cited: 3
 
Title : p66Shc signaling is involved in stress responses elicited by anthracycline treatment of rat cardiomyoblasts
Author(s): Sampaio, SF; Branco, AF; Wojtala, A; Vega-Naredo, I; Wieckowski, MR; Oliveira, PJ
Source : ARCHIVES OF TOXICOLOGY Document Type : Article Volume : 90 Issue: 7 Pages: 1669-1684 DOI: 10.1007/s00204-015-1583-9 Published: 2016 JUL
Times Cited: 2
 
Title : Polyphenols from Cymbopogon citratus leaves as topical anti-inflammatory agents
Author(s): Costa, G; Ferreira, JP; Vitorino, C; Pina, ME; Sousa, JJ; Figueiredo, IV; Batista, MT
Source : JOURNAL OF ETHNOPHARMACOLOGY Document Type : Article Volume : 178 Issue: Pages: 222-228 DOI: 10.1016/j.jep.2015.12.016 Published: 2016 FEB 3
Times Cited: 3
 
Title : Preclinical safety of solid lipid nanoparticles and nanostructured lipid carriers: Current evidence from in vitro and in vivo evaluation
Author(s): Doktorovova, S; Kovacevic, AB; Garcia, ML; Souto, EB
Source : EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS Document Type : Article Volume : 108 Issue: Pages: 235-252 DOI: 10.1016/j.ejpb.2016.08.001 Published: 2016 NOV
Times Cited: 1
 
Title : Presymptomatic MPTP Mice Show Neurotrophic S100B/mRAGE Striatal Levels
Author(s): Viana, SD; Fernandes, RC; Canas, PM; Silva, AM; Carvalho, F; Ali, SF; Ribeiro, CAF; Pereira, FC
Source : CNS NEUROSCIENCE & THERAPEUTICS Document Type : Article Volume : 22 Issue: 5 Pages: 396-403 DOI: 10.1111/cns.12508 Published: 2016 MAY
Times Cited: 2
 
Title : Protective effects of a blueberry extract in acute inflammation and collagen-induced arthritis in the rat
Author(s): Figueira, ME; Oliveira, M; Direito, R; Rocha, J; Alves, P; Serra, AT; Duarte, C; Bronze, R; Fernandes, A; Brites, D; Freitas, M; Fernandes, E; Sepodes, B
Source : BIOMEDICINE & PHARMACOTHERAPY Document Type : Article Volume : 83 Issue: Pages: 1191-1202 DOI: 10.1016/j.biopha.2016.08.040 Published: 2016 OCT
Times Cited: 0
 
Title : Pulmonary pharmacokinetics of levofloxacin in rats after aerosolization of immediate-release chitosan or sustained-release PLGA microspheres
Author(s): Gaspar, MC; Gregoire, N; Sousa, JJS; Pais, AACC; Lamarche, I; Gobin, P; Olivier, JC; Marchand, S; Couet, W
Source : EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES Document Type : Article Volume : 93 Issue: Pages: 184-191 DOI: 10.1016/j.ejps.2016.08.024 Published: 2016 OCT 10
Times Cited: 0
 
Title : Red wine polyphenol extract efficiently protects intestinal epithelial cells from inflammation via opposite modulation of JAK/STAT and Nrf2 pathways
Author(s): Nunes, C; Teixeira, N; Serra, D; Freitas, V; Almeida, L; Laranjinha, J
Source : TOXICOLOGY RESEARCH Document Type : Article Volume : 5 Issue: 1 Pages: 53-65 DOI: 10.1039/c5tx00214a Published: 2016
Times Cited: 3
 
Title : Renal risk-benefit determinants of recombinant human erythropoietin therapy in the remnant kidney rat model - hypertension, anaemia, inflammation and drug dose
Author(s): Ribeiro, S; Garrido, P; Fernandes, J; Vala, H; Rocha-Pereira, P; Costa, E; Belo, L; Reis, F; Santos-Silva, A
Source : CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY Document Type : Article Volume : 43 Issue: 3 Pages: 343-354 DOI: 10.1111/1440-1681.12541 Published: 2016 MAR
Times Cited: 0
 
Title : Responsive Plasmid DNA Hydrogels: A New Approach for Biomedical Applications
Author(s): Costa, D; Valente, AJM; Queiroz, J
Source : HANDBOOK OF POLYMERS FOR PHARMACEUTICAL TECHNOLOGIES, VOL 4: BIOACTIVE AND COMPATIBLE SYNTHETIC/HYBRID POLYMERS Document Type : Article; Book Chapter Volume : Issue: Pages: 145-162 DOI: Published: 2016
Times Cited: 0
 
Title : Role of microRNAs in the regulation of innate immune cells under neuroinflammatory conditions
Author(s): Cardoso, AL; Guedes, JR; de Lima, MCP
Source : CURRENT OPINION IN PHARMACOLOGY Document Type : Article Volume : 26 Issue: Pages: 1-9 DOI: 10.1016/j.coph.2015.09.001 Published: 2016 FEB
Times Cited: 13
 
Title : Sex differences in excipient effects: Enhancement in ranitidine bioavailability in the presence of polyethylene glycol in male, but not female, rats
Author(s): Afonso-Pereira, F; Murdan, S; Sousa, J; Veiga, F; Basit, AW
Source : INTERNATIONAL JOURNAL OF PHARMACEUTICS Document Type : Article Volume : 506 Issue: 1-2 Pages: 237-241 DOI: 10.1016/j.ijpharm.2016.04.022 Published: 2016 JUN 15
Times Cited: 0
 
Title : Theranostic Fibers for Simultaneous Imaging and Drug Delivery
Author(s): Jin, M; Yu, DG; Geraldes, CFGC; Williams, GR; Bligh, SWA
Source : MOLECULAR PHARMACEUTICS Document Type : Article Volume : 13 Issue: 7 Pages: 2457-2465 DOI: 10.1021/acs.molpharmaceut.6b00197 Published: 2016 JUL
Times Cited: 2
 
Title : Validation of HPLC Method for Quantitative Determination of Clotrimazole in Microemulsion and Microemulsion-Based Gel
Author(s): Boonme, P; Kaewbanjong, J; Amnuaikit, T; Souto, EB
Source : LATIN AMERICAN JOURNAL OF PHARMACY Document Type : Article Volume : 35 Issue: Pages: 1222-1227 DOI: Published: 2016
Times Cited: 0
 
Title : Ziziphora tenuior L. essential oil from Dana Biosphere Reserve (Southern Jordan); Chemical characterization and assessment of biological activities
Author(s): Abu-Darwish, MS; Cabral, C; Goncalves, MJ; Cavaleiro, C; Cruz, MT; Paoli, M; Tomi, F; Efferth, T; Salgueiro, L
Source : JOURNAL OF ETHNOPHARMACOLOGY Document Type : Article Volume : 194 Issue: Pages: 963-970 DOI: 10.1016/j.jep.2016.10.076 Published: 2016 DEC 24
Times Cited: 0