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Código da Operação: Grant Agreement no. 278588

Acrónimo: DO-HEALTH

Referência: GA 278588 DO-HEALTH

Título: VitaminD3-Omega3-Home Exercise- HeALTHy Ageing and Longevity Trial

Área Científica: Saúde

Síntese do Projeto: DO-HEALTH is a clinical trial designed (i) to support healthy aging in European seniors and (ii) to establish whether vitamin D, omega-3 fatty acids, and a simple home exercise program will prevent disease at older age and thereby prolong healthy life expectancy. To achieve these aims, DO-HEALTH aimed to enroll 2152 community-dwelling men and women who are 70 years and older, an age when chronic diseases increase substantially. The DO-HEALTH seniors were recruited from 7 European cities (Zurich, Basel, Geneva, Toulouse, Berlin, Innsbruck and Coimbra) and were randomized in a 2x2x2 factorial design trial to a simple home exercise program and/or vitamin D, and/or omega-3 fatty acids, over a 3 year period. This will allow to test the benefit of the interventions in the prevention of 5 primary endpoints: the risk of incident non-vertebral fractures; the risk of functional decline; the risk of blood pressure increase; the risk of cognitive decline; and the rate of any infection. Key secondary endpoints include risk of hip fracture, rate of falls, pain in symptomatic knee osteoarthritis, gastro-intestinal symptoms, mental and oral health, quality of life, and life-expectancy. DO-HEALTH seniors were followed for 3 years, in-person, and in 3-monthly intervals (4 clinical visits and 9 phone calls) at the 7 recruitment centers.

Investigador Responsável: Doutor José António P. Silva

Programa de Financiamento: 7PQ - Capacidades

Instituição Financiadora: European Comission

Data de início: 01-01-2012

Data de conclusão: 30-06-2018

Instituições participantes no Projeto: Universität Zürich, Universite de Geneve, Universitätsspital Basel, Centre Hospitalier Universitaire de Toulouse, Charite - Universitaetsmedizin Berlin, Friedrich-Alexander-Universitaet Erlangen Nuernberg, Max Rubner- Institut, Bundesforschungsinstitut fur Ernaehrung und Lebensmittel, Medizinische Universitaet Innsbruck, Universidade de Coimbra (Participante), The University of Manchester, The University of Sheffield, International Osteoporosis Foundation, Novamen Sas, Ferrari Stephen Mario, Ultra Images Ag, Technische Universitaet Dresden, Pharmalys Ltd, Maetzel Andreas - Maetzel Consulting, Dsm Nutritional Products Ltd, Nestec Sa, Roche Diagnostics (Schweiz) Ag

Custo total elegível (EUR): 1.3067.968,25€

Apoio financeiro da UE: 5.999.548€

Apoio financeiro nacional: 201.738,53€

Técnico do Projeto: Paula Lopes

Contacto: 239247024