Coimbra Institute for Clinical and Biomedical Research

iCBR Coimbra Institute for Clinical and Biomedical Research

2018

Almeida Paiva R, Martins-Marques T, Jesus K, Ribeiro-Rodrigues T, Zuzarte M, Silva A, Reis L, da Silva M, Pereira P, Vader P, Petrus Gerardus Sluijter J, Gonçalves L, Cruz MT, Girao H. Ischaemia alters the effects of cardiomyocyte-derived extracellular vesicles on macrophage activation. J Cell Mol Med. 2018 Dec 4. doi: 10.1111/jcmm.14014. [Epub ahead of print] PMID: 30516028

Alves A, Mamede AC, Alves M, Oliveira PF, Rocha SM, Botelho F, Maia CJ. Glycolysis inhibition as a strategy for hepatocellular carcinoma treatment? Curr Cancer Drug Targets. 2018 Apr 30. doi: 10.2174/1568009618666180430144441. PMID: 29749314

Alves MRP, Boia R, Campos EJ, Martins J, Nunes S, Madeira MH, Santiago AR, Pereira FC, Reis F, Ambrósio AF, Baptista FI. Subtle thinning of retinal layers without overt vascular and inflammatory alterations in a rat model of prediabetes. Mol Vis. 2018 May 18;24:353-366. eCollection 2018. PMID: 29853770

Bacalhau M, Simões M, Rocha MC, Hardy SA, Vincent AE, Durães J, Macário MC, Santos MJ, Rebelo O, Lopes C, Pratas J, Mendes C, Zuzarte M, Rego AC, Girão H, Wong LC, Taylor RW, Grazina M. Disclosing the functional changes of two genetic alterations in a patient with Chronic Progressive External Ophthalmoplegia: Report of the novel mtDNA m.7486G>A variant. Neuromuscul Disord. 2018 Apr;28(4):350-360. doi: 10.1016/j.nmd.2017.11.006. Epub 2017 Nov 23. PMID: 29398297

Baptista FI, Pinheiro H, Gomes CA, Ambrósio AF. Impairment of Axonal Transport in Diabetes: Focus on the Putative Mechanisms Underlying Peripheral and Central Neuropathies. Mol Neurobiol. 2018 Jul 12. doi: 10.1007/s12035-018-1227-1.PMID: 30003516

Baptista R, Marques C, Catarino S, Enguita FJ, Costa MC, Matafome P, Zuzarte M, Castro G, Reis A, Monteiro P, Pêgo M, Pereira P, Girão H. MicroRNA-424(322) as a new marker of disease progression in pulmonary arterial hypertension and its role in right ventricular hypertrophy by targeting SMURF1. Cardiovasc Res. 2018 Jan 1;114(1):53-64. doi: 10.1093/cvr/cvx187. PMID: 29016730

Bessa C, Soares J, Raimundo L, Loureiro JB, Gomes C, Reis F, Soares ML, Santos D, Dureja C, Chaudhuri SR, Lopez-Haber C, Kazanietz MG, Gonçalves J, Simões MF, Rijo P, Saraiva L. Discovery of a small-molecule protein kinase Cδ-selective activator with promising application in colon cancer therapy. Cell Death Dis. 2018 Jan 18;9(2):23. doi: 10.1038/s41419-017-0154-9. PMID: 29348560

Bonini S, Lambiase A, Rama P, Filatori I, Allegretti M, Chao W, Mantelli F; REPARO Study Group. Phase I Trial of Recombinant Human Nerve Growth Factor for Neurotrophic Keratitis. Ophthalmology. 2018 Sep;125(9):1468-1471. doi: 10.1016/j.ophtha.2018.03.004. Epub 2018 Apr 10. No abstract available. PMID: 29653861

Bonini S, Lambiase A, Rama P, Sinigaglia F, Allegretti M, Chao W, Mantelli F; REPARO Study Group. Phase II Randomized, Double-Masked, Vehicle-Controlled Trial of Recombinant Human Nerve Growth Factor for Neurotrophic Keratitis. Ophthalmology. 2018 Sep;125(9):1332-1343. doi: 10.1016/j.ophtha.2018.02.022. Epub 2018 Apr 10. PMID: 29653858

Brito D, Cardim N, Lopes LR, Belo A, Mimoso J, Gonçalves L, Madeira H; Portuguese Registry of Hypertrophic Cardiomyopathy (PRo-HCM) Investigators. Awareness of Fabry disease in cardiology: A gap to be filled. Rev Port Cardiol. 2018 Jun;37(6):457-466. doi: 10.1016/j.repc.2018.03.010. Epub 2018 May 22. PMID: 29801713

Caixinha M, Oliveira P, Aires ID, Ambrósio AF, Santiago AR, Santos M, Santos J. In Vivo Characterization of Corneal Changes in a Type 1 Diabetic Animal Model. Ultrasound Med Biol. 2018 Dec 31. pii: S0301-5629(18)30511-8. doi: 10.1016/j.ultrasmedbio.2018.11.002. PMID:30606634

Campos A, Campos EJ, do Carmo A, Caramelo F, Martins J, Sousa JP, Ambrósio AF, Silva R. Evalua tion of markers of outcome in real-world treatment of diabetic macular edema. Eye Vis (Lond). 2018 Oct 11;5:27. doi: 10.1186/s40662-018-0119-9. eCollection 2018. PMID: 30386806

Campos A, Campos EJ, do Carmo A, Patrício M, Castro de Sousa JP, Ambrósio AF, Silva R. Choroidal thickness changes stratified by outcome in real-world treatment of diabetic macular edema. Graefes Arch Clin Exp Ophthalmol. 2018 Oct;256(10):1857-1865. doi: 10.1007/s00417-018-4072-z. Epub 2018 Jul 23.

Campos EJ, Martins J, Brudzewsky D, Correia S, Santiago AR, Woldbye DP, Ambrósio AF. Impact of type 1 diabetes mellitus and sitagliptin treatment on the neuropeptide Y system of rat retina. Clin Exp Ophthalmol. 2018 Sep;46(7):783-795. doi: 10.1111/ceo.13176. Epub 2018 Mar 5. PMID: 29442423

Capela de Matos RR, Othman MAK, Ferreira GM, Costa ES, Melo JB, Carreira IM, de Souza MT, Lopes BA, Emerenciano M, Land MGP, Liehr T, Ribeiro RC, Silva MLM. Molecular approaches identify a cryptic MECOM rearrangement in a child with a rapidly progressive myeloid neoplasm. Cancer Genet. 2018 Feb;221:25-30. doi: 10.1016/j.cancergen.2017.12.002. Epub 2017 Dec 19. PMID:29405993

Cardim N, Brito D, Rocha Lopes L, Freitas A, Araújo C, Belo A, Gonçalves L, Mimoso J, Olivotto I, Elliott P, Madeira H; participating centres. The Portuguese Registry of Hypertrophic Cardiomyopathy: Overall results. Rev Port Cardiol. 2018 Jan;37(1):1-10. doi: 10.1016/j.repc.2017.08.005. Epub 2018 Jan 19. PMID: 29358015

Cardoso S, Seiça RM, Moreira PI. Uncoupling Protein 2 Inhibition Exacerbates Glucose Fluctuation-Mediated Neuronal Effects. Neurotox Res. 2018 Feb;33(2):388-401. doi: 10.1007/s12640-017-9805-y. Epub 2017 Sep 5. PMID: 28875237

Carvalho MJ, Laranjo M, Abrantes AM, Casalta-Lopes J, Sarmento-Santos D, Costa T, Serambeque B, Almeida N, Gonçalves T, Mamede C, Encarnação J, Oliveira R, Paiva A, de Carvalho R, Botelho F, Oliveira C. Endometrial Cancer Spheres Show Cancer Stem Cells Phenotype and Preference for Oxidative Metabolism. Pathol Oncol Res. 2018 Nov 29. doi: 10.1007/s12253-018-0535-0. PMID:30499076

Coelho A, Paula A, Mota M, Laranjo M, Abrantes M, Carrilho F, Ferreira M, Silva M, Botelho F, Carrilho E. Dental caries and bacterial load in saliva and dental biofilm of type 1 diabetics on continuous subcutaneous insulin infusion. J Appl Oral Sci. 2018 Jun 11;26:e20170500. doi: 10.1590/1678-7757-2017-0500. PMID: 29898180

Coelho-Santos V, Cardoso FL, Leitão RA, Fontes-Ribeiro CA, Silva AP. Impact of developmental exposure to methylphenidate on rat brain's immune privilege and behavior: Control versus ADHD model. Brain Behav Immun. 2018 Feb;68:169-182. doi: 10.1016/j.bbi.2017.10.016. Epub 2017 Oct 20. PMID: 29061363

Coelho-Santos V, Cardoso FL, Magalhães A, Ferreira-Teixeira M, Leitão RA, Gomes C, Rito M, Barbosa M, Fontes-Ribeiro CA, Silva AP. Effect of chronic methylphenidate treatment on hippocampal neurovascular unit and memory performance in late adolescent rats. Eur Neuropsychopharmacol. 2018 Dec 13. pii: S0924-977X(18)31992-8. doi: 10.1016/j.euroneuro.2018.12.007. [Epub ahead of print] PMID: 30554860

Costa BP, Gonçalves AC, Abrantes AM, Alves R, Matafome P, Seiça R, Sarmento-Ribeiro AB, Botelho MF, Castro-Sousa F. Tissular growth factors profile after teduglutide administration on an animal model of intestinal anastomosis. Nutr Hosp. 2018 Jan 16;35(1):185-193. doi: 10.20960/nh.1326. PMID: 29565168

Costa BP, Gonçalves AC, Abrantes AM, Alves R, Matafome P, Seiça R, Sarmento-Ribeiro AB, Botelho MF, Castro-Sousa F. Intestinal Epithelial Stem Cells: Distinct Behavior After Surgical Injury and Teduglutide Administration. J Invest Surg. 2018 Jun;31(3):243-252. doi: 10.1080/08941939.2017.1294217. Epub 2017 Mar 31. PMID: 28362133

Davidson SM, Andreadou I, Barile L, Birnbaum Y, Cabrera-Fuentes HA, Cohen MV, Downey JM, Girao H, Pagliaro P, Penna C, Pernow J, Preissner KT, Ferdinandy P. Circulating blood cells and extracellular vesicles in acute cardioprotection. Cardiovasc Res. 2018 Dec 24. doi: 10.1093/cvr/cvy314. [Epub ahead of print] PMID: 30590395

de Almeida Fernandes D, António N, Madeira M, Sousa P, Ventura M, Cristóvão J, Nascimento J, Elvas L, Gonçalves L, Pego GM. Unsafe Drug Use and Arrhythmic Events in Brugada Patients with ICD: Results of a Long-Term Follow-Up. Cardiovasc Drugs Ther. 2018 Feb;32(1):23-28. doi: 10.1007/s10557-018-6770-5. PMID: 29372449

Delgado-Silva J, Fernandes R, Pita IR, Pereira FC, Jaguszewski M, Gutiérrez-Chico JL, Ribeiro-Rodrigues T, Girão H, Ioannou A, Gonçalves L. Intravascular imaging, histopathological analysis, and catecholamine quantification following catheter-based renal denervation in a swine model: the impact of prebifurcation energy delivery. Hypertens Res. 2018 Sep;41(9):708-717. doi: 10.1038/s41440-018-0072-y. Epub 2018 Jul 13. PMID: 30006641

Dinis P, Teixeira R, Dores H, Correia P, Lekedal H, Bergman M, Cachulo MC, Cardoso J, Gonçalves L. Exercise-induced cardiac remodeling in athletes and in special forces soldiers. Rev Port Cardiol. 2018 Mar;37(3):249-256. doi: 10.1016/j.repc.2017.06.010. Epub 2018 Mar 31. PMID: 29609946

Dinis P, Teixeira R, Puga L, Lourenço C, Cachulo MC, Gonçalves L. Eosinophilic Myocarditis: Clinical Case and Literature Review. Arq Bras Cardiol. 2018 Jun;110(6):597-599. doi: 10.5935/abc.20180089. English, Portuguese. No abstract available. PMID: 30226920

ESC Board . The future of continuing medical education: the roles of medical professional societies and the health care industry: Position paper prepared with contributions from the European Society of Cardiology Committees for Advocacy, Education and Industry Relations, Endorsed by the Board of the European Society of Cardiology. Eur Heart J. 2018 Feb 28. doi: 10.1093/eurheartj/ehy003. PMID: 29506125

Fernandes R, Viana SD, Nunes S, Reis F. Diabetic gut microbiota dysbiosis as an inflammaging and immunosenescence condition that fosters progression of retinopathy and nephropathy. Biochim Biophys Acta Mol Basis Dis. 2018 Oct 1. pii: S0925-4439(18)30367-3. doi: 10.1016/j.bbadis.2018.09.032. PMID: 30287404

Ferreira JA, Gonçalves L, Naghipoor J, de Oliveira P, Rabczuk T. The effect of plaque eccentricity on blood hemodynamics and drug release in a stented artery. Med Eng Phys. 2018 Oct;60:47-60. doi: 10.1016/j.medengphy.2018.07.014. Epub 2018 Aug 12. PMID: 30111489

Ferreira MJV, Oliveira-Santos M, Silva R, Gomes A, Ferreira N, Abrunhosa A, Lima J, Pego M, Gonçalves L, Castelo-Branco M. Assessment of atherosclerotic plaque calcification using F18-NaF PET-CT. J Nucl Cardiol. 2018 Oct;25(5):1733-1741. doi: 10.1007/s12350-016-0776-9. Epub 2017 Jan 9. PMID: 30281692

Fontes-Carvalho R, Gonçalves L. The Portuguese Journal of Cardiology. Eur Heart J. 2018 Mar 7;39(10):829-830. doi: 10.1093/eurheartj/ehy054. PMID: 29522217

Girao HT, Hermet P, Masenelli B, Haines J, Mélinon P, Machon D. Pressure-Induced Sublattice Disordering in SnO_{2}: Invasive Selective Percolation. Phys Rev Lett. 2018 Jun 29;120(26):265702. doi: 10.1103/PhysRevLett.120.265702. PMID: 30004742

Gonçalves A, Almeida L, Silva AP, Fontes-Ribeiro C, Ambrósio AF, Cristóvão A, Fernandes R. The dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin ameliorates retinal endothelial cell dysfunction triggered by inflammation. Biomed Pharmacother. 2018 Jun;102:833-838. doi: 10.1016/j.biopha.2018.03.144. Epub 2018 Apr 5. PMID: 29605771

Kotecha D, Bax JJ, Carrera C, Casadei B, Merkely B, Anker SD, Vardas PE, Kearney PP, Roffi M, Ros M, Vahanian A, Weidinger F, Beeri R, Budaj A, Calabrò P, Czerwinska-Jelonkiewicz K, D'Ascenzi F, De Potter T, Fox KF, Hartikainen J, McAdam B, Milicic D, Pasquet AA, Sionis A, Sohaib SMA, Tsioufis C, Verhorst PMJ, Kirchhof P; ESC Scientific Document Group ; 2016 ESC Education Conference. Roadmap for cardiovascular education across the European Society of Cardiology: inspiring better knowledge and skills, now and for the future. Eur Heart J. 2018 Jan 31. doi: 10.1093/eurheartj/ehy058.

Leitão J, Carvalhana S, Silva AP, Velasco F, Medeiros I, Alves AC, Bourbon M, Oliveiros B, Carvalho A, Cortez-Pinto H. No Evidence for Lower Levels of Serum Vitamin D in the Presence of Hepatic Steatosis. A Study on the Portuguese General Population. Int J Med Sci. 2018 Nov 29;15(14):1778-1786. doi: 10.7150/ijms.26586. eCollection 2018. PMID: 30588203

Leitão RA, Sereno J, Castelhano JM, Gonçalves SI, Coelho-Santos V, Fontes-Ribeiro C, Castelo-Branco M, Silva AP. Aquaporin-4 as a New Target against Methamphetamine-Induced Brain Alterations: Focus on the Neurogliovascular Unit and Motivational Behavior. Mol Neurobiol. 2018 Mar;55(3):2056-2069. doi: 10.1007/s12035-017-0439-0. Epub 2017 Mar 10. PMID: 28283882

Lousa I, Nascimento H, Rocha S, Catarino C, Reis F, Rêgo C, Santos-Silva A, Seabra A, Ribeiro S, Belo L. Influence of the 6-month physical activity programs on renal function in obese boys. Pediatr Res. 2018 May;83(5):1011-1015. doi: 10.1038/pr.2018.15. Epub 2018 Apr 11. PMID: 29638229

Madeira M, Reis L, Teixeira R, Dinis P, Costa M, Gonçalves L. Device entrapped in subvalvular apparatus: A surprising result. Rev Port Cardiol. 2018 Aug;37(8):719-721. doi: 10.1016/j.repc.2017.05.015. Epub 2018 Jun 19. PMID: 29929835

Madeira MH, Rashid K, Ambrósio AF, Santiago AR, Langmann T. Blockade of microglial adenosine A2A receptor impacts inflammatory mechanisms, reduces ARPE-19 cell dysfunction and prevents photoreceptor loss in vitro. Sci Rep. 2018 Feb 2;8(1):2272. doi: 10.1038/s41598-018-20733-2. PMID: 29396515

Malva JO, Amado A, Rodrigues A, Mota-Pinto A, Cardoso AF, Teixeira AM, Todo-Bom A, Devesa A, Ambrósio AF, Cunha AL, Gomes B, Dantas C, Abreu C, Santana I, Bousquet J, Apóstolo J, Santos L, Meneses de Almeida L, Illario M, Veríssimo R, Rodrigues V, Veríssimo MT. The Quadruple Helix-Based Innovation Model of Reference Sites for Active and Healthy Ageing in Europe: The Ageing@Coimbra Case Study. Front Med (Lausanne). 2018 May 8;5:132. doi: 10.3389/fmed.2018.00132. eCollection 2018. PMID: 29868588

Martins JL, Afreixo V, Santos J, Gonçalves L. Fractional Flow Reserve-Guided Strategy in Acute Coronary Syndrome. A Systematic Review and Meta-Analysis. Arq Bras Cardiol. 2018 Oct;111(4):542-550. doi: 10.5935/abc.20180170. Epub 2018 Sep 21.

Martins JL, Afreixo V, Santos L, Costa M, Santos J, Gonçalves L. Medical treatment or revascularisation as the best approach for spontaneous coronary artery dissection: A systematic review and meta-analysis. Eur Heart J Acute Cardiovasc Care. 2018 Oct;7(7):614-623. doi: 10.1177/2048872617706502. Epub 2017 Apr 28. PMID: 28452228

Martins JL, Paiva L, Costa M, Gonçalves L.Thrombus in left atrial appendage - Overcoming percutaneous closure limitations. Rev Port Cardiol. 2018 Mar;37(3):269-270. doi: 10.1016/j.repc.2017.04.006. Epub 2018 Mar 30.PMID: 29606299

Martins S, Carvalheiro T, Laranjeira P, Martinho A, Elvas L, Gonçalves L, Tomaz C, António N, Paiva A. Impact of cardiac resynchronization therapy on circulating IL-17 producing cells in patients with advanced heart failure. J Interv Card Electrophysiol. 2018 Nov 27. doi: 10.1007/s10840-018-0491-3. [Epub ahead of print] PMID: 30483979

Paiva LV, Costa MP, Barra SC, Gonçalves L. Intracardiac echography for left atrial appendage closure : A step-by-step tutorial. Catheter Cardiovasc Interv. 2018 Sep 30. doi: 10.1002/ccd.27898. PMID: 30269433

Pars S, Cristo F, Inácio JM, Rosas G, Carreira IM, Melo JB, Mendes P, Martins DS, de Almeida LP, Maio J, Anjos R, Belo JA. Generation and characterization of a human iPS cell line from a patient-related control to study disease mechanisms associated with DAND5 p.R152H alteration. Stem Cell Res. 2018 May;29:202-206. doi: 10.1016/j.scr.2018.04.015. Epub 2018 Apr 28. PMID: 29730570

Patrício M, Pereira J, Crisóstomo J, Matafome P, Gomes M, Seiça R, Caramelo F. Using Resistin, glucose, age and BMI to predict the presence of breast cancer. BMC Cancer. 2018 Jan 4;18(1):29. doi: 10.1186/s12885-017-3877-1. PMID: 29301500

Pereira O, Teixeira A, Sampaio-Marques B, Castro I, Girão H, Ludovico P. Signalling mechanisms that regulate metabolic profile and autophagy of acute myeloid leukaemia cells. J Cell Mol Med. 2018 Oct;22(10):4807-4817. doi: 10.1111/jcmm.13737. Epub 2018 Aug 17. PMID: 30117681

Pinheiro H, Gaspar R, Baptista FI, Fontes-Ribeiro CA, Ambrósio AF, Gomes CA. Adenosine A2A Receptor Blockade Modulates Glucocorticoid-Induced Morphological Alterations in Axons, But Not in Dendrites, of Hippocampal Neurons. Front Pharmacol. 2018 Mar 19;9:219. doi: 10.3389/fphar.2018.00219. eCollection 2018. PMID: 29615903

Pinho TS, Correia SC, Perry G, Ambrósio AF, Moreira PI. Diminished O-GlcNAcylation in Alzheimer's disease is strongly correlated with mitochondrial anomalies. Biochim Biophys Acta Mol Basis Dis. 2018 Nov 6. pii: S0925-4439(18)30440-X. doi: 10.1016/j.bbadis.2018.10.037. PMID: 30412792

PMID: 30039271

Providência R, Karim N, Srinivasan N, Honarbakhsh S, Vidigal Ferreira MJ, Gonçalves L, Marijon E, Lambiase PD. Impact of QTc formulae in the prevalence of short corrected QT interval and impact on probability and diagnosis of short QT syndrome. Heart. 2018 Mar;104(6):502-508. doi: 10.1136/heartjnl-2017-311673. Epub 2017 Sep 27. PMID: 28954836

Rebelo-Marques A, De Sousa Lages A, Andrade R, Ribeiro CF, Mota-Pinto A, Carrilho F, Espregueira-Mendes J. Aging Hallmarks: The Benefits of Physical Exercise. Front Endocrinol (Lausanne). 2018 May 25;9:258. doi: 10.3389/fendo.2018.00258. eCollection 2018. Review. PMID: 29887832

Reis L, Paiva L, Costa M, Silva J, Teixeira R, Botelho A, Dinis P, Madeira M, Ribeiro J, Nascimento J, Gonçalves L. Registry of left atrial appendage closure and initial experience with intracardiac echocardiography. Rev Port Cardiol. 2018 Sep;37(9):763-772. doi: 10.1016/j.repc.2018.03.009. Epub 2018 Sep 13. PMID: 30219202

Reis L, Teixeira R, Fernandes A, Almeida I, Madeira M, Silva J, Botelho A, Pais J, Nascimento J, Gonçalves L. Prevention of Sudden Cardiac Death in Hypertrophic Cardiomyopathy: What has Changed in The Guidelines? Arq Bras Cardiol. 2018 Jun;110(6):524-531. doi: 10.5935/abc.20180099. PMID: 30226910

Ribeiro IP, Caramelo F, Esteves L, Oliveira C, Marques F, Barroso L, Melo JB, Carreira IM. Genomic and epigenetic signatures associated with survival rate in oral squamous cell carcinoma patients. J Cancer. 2018 Apr 27;9(11):1885-1895. doi: 10.7150/jca.23239. eCollection 2018. PMID:29896272

Ribeiro IP, Rodrigues JM, Mascarenhas A, Kosyakova N, Caramelo F, Liehr T, Melo JB, Carreira IM. Cytogenetic, genomic, and epigenetic characterization of the HSC-3 tongue cell line with lymph node metastasis. J Oral Sci. 2018 Mar 24;60(1):70-81. doi: 10.2334/josnusd.16-0811. Epub 2018 Feb 26. PMID:29479029

Ribeiro JM, Cachulo MDC, Teixeira R, Gonçalves L. Going the extra mile: percutaneous transseptal valve-in-valve implantation and leak closure. EuroIntervention. 2018 Feb 2;13(15):e1776-e1777. doi: 10.4244/EIJ-D-17-00183. PMID: 28606885

Ribeiro M, Castelhano J, Petrella LI, Sereno J, Rodrigues T, Neves C, Letra L, Baptista FI, Seiça R, Matafome P, Castelo-Branco M. High-fat diet induces a neurometabolic state characterized by changes in glutamate and N-acetylaspartate pools associated with early glucose intolerance: An in vivo multimodal MRI study. J Magn Reson Imaging. 2018 Jan 26. doi: 10.1002/jmri.25942. PMID: 29377412

Rodrigues CFD, Serrano E, Patrício MI, Val MM, Albuquerque P, Fonseca J, Gomes CMF, Abrunhosa AJ, Paiva A, Carvalho L, Botelho MF, Almeida L, Carreira IM, Alpoim MC. Stroma-derived IL-6, G-CSF and Activin-A mediated dedifferentiation of lung carcinoma cells into cancer stem cells. Sci Rep. 2018 Aug 1;8(1):11573. doi: 10.1038/s41598-018-29947-w. PMID: 30069023

Rodrigues CFD, Serrano E, Patrício MI, Val MM, Albuquerque P, Fonseca J, Gomes CMF, Abrunhosa AJ, Paiva A, Carvalho L, Botelho MF, Almeida L, Carreira IM, Alpoim MC. Stroma-derived IL-6, G-CSF and Activin-A mediated dedifferentiation of lung carcinoma cells into cancer stem cells. Sci Rep. 2018 Aug 1;8(1):11573. doi: 10.1038/s41598-018-29947-w. PMID: 30069023

Rodrigues TM, Cortez L, Murta JN, Paiva C. Low-vision aids improve the visual performance of children with bilateral chorioretinal coloboma. J AAPOS. 2018 Jun;22(3):202-206. doi: 10.1016/j.jaapos.2017.12.020. Epub 2018 May 4. PMID: 29730056

Rodrigues TM, Marques JP, Soares M, Dolan MJ, Melo P, Simão S, Teles J, Figueira J, Murta JN, Silva R. PERIPAPILLARY NEUROVASCULAR COUPLING IN THE EARLY STAGES OF DIABETIC RETINOPATHY. Retina. 2018 Sep 26. doi: 10.1097/IAE.0000000000002328. PMID: 30260919

Rodrigues-Neves AC, Aires ID, Vindeirinho J, Boia R, Madeira MH, Gonçalves FQ, Cunha RA, Santos PF, Ambrósio AF, Santiago AR. Elevated Pressure Changes the Purinergic System of Microglial Cells. Front Pharmacol. 2018 Jan 24;9:16. doi: 10.3389/fphar.2018.00016. eCollection 2018. PMID: 29416510

Santiago AR, Boia R, Aires ID, Ambrósio AF, Fernandes R. Sweet Stress: Coping With Vascular Dysfunction in Diabetic Retinopathy. Front Physiol. 2018 Jul 13;9:820. doi: 10.3389/fphys.2018.00820. eCollection 2018. Review. PMID: 30057551

Sena CM, Cipriano MA, Botelho MF, Seiça RM. Lipoic Acid Prevents High-Fat Diet-Induced Hepatic Steatosis in Goto Kakizaki Rats by Reducing Oxidative Stress Through Nrf2 Activation. Int J Mol Sci. 2018 Sep 11;19(9). pii: E2706. doi: 10.3390/ijms19092706. PMID:30208622

Sena CM, Leandro A, Azul L, Seiça R, Perry G. Vascular Oxidative Stress: Impact and Therapeutic Approaches.Front Physiol. 2018 Dec 4;9:1668. doi: 10.3389/fphys.2018.01668. eCollection 2018. Review.PMID: 30564132

Viana SD, Reis F, Alves R. Therapeutic Use of mTOR Inhibitors in Renal Diseases: Advances, Drawbacks, and Challenges. Oxid Med Cell Longev. 2018 Oct 29;2018:3693625. doi: 10.1155/2018/3693625. eCollection 2018. PMID: 30510618

Viola M, Sequeira J, Seiça R, Veiga F, Serra J, Santos AC, Ribeiro AJ. Subcutaneous delivery of monoclonal antibodies: How do we get there? J Control Release. 2018 Sep 28;286:301-314. doi: 10.1016/j.jconrel.2018.08.001. Epub 2018 Aug 2. Review. PMID: 30077735

2018

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