Henrique Girão graduated in biochemistry in 1995 from the Faculty of Sciences and Technology of University of Coimbra, Portugal and completed his Ph.D. in 2006 at the Faculty Medicine of University of Coimbra, Portugal. Henrique did part of his PhD work at Department of Biochemistry, University of Dundee (Scotland) and Lab. for Nutrition and Vision Research, Tufts University, Boston, (USA). He moved to Institut de Biologia Molecular de Barcelona - CSIC in 2006 as a PostDoc Research fellow. Henrique Girao (HG) is currently Principal Investigator at the Faculty of Medicine of University of Coimbra (FMUC), Deputy Director for Research and Development, Vice-chairperson of the Cardiovascular Council, Leader of the Group “Ubiquitin-dependent Proteolysis and Intercellular Communication”, Director of the Microscopy and Bioimaging Lab. HG coordinates the Group of Cellular and Translational Cardiology that brings together basic researchers and clinicians at Centre for Innovative Biomedicine and Biotechnology of UC.
HG also coordinates the PhD programme in Health Sciences and the Master Course of Biomedical Research, and integrates the Board of Directors of the Inter-University Doctoral Programme in Ageing Chronic Diseases. In the last 5 years HG has supervised 16 PhD Thesis, 30 Master Thesis and 7 Posdocs. HG has been Jury in 16 PhD Defense, as main opponent, and more than 30 Master Defense.
HG serves at the Nucleus of the Working Group on Cellular Biology of the Heart of ESC and integrates the management committee of 3 COST actions. HG published 78 papers in peer-reviewed journals, including Circ Res, Cardiovasc Res, Life Sci Alliance, Trends Cell Biol, Trends Mol Med, Autophagy, Molec Cell Proteomics and J Extracell Vesicles. HG has coordinated 6 Research grants and participated in other 5 funded by FCT and EU, securing > 1,5 M€. HG launched and heads the FMUC Health Communication Office, aiming to promote scientific culture and literacy in the society.
HG has served has reviewer for several Portuguese and international prestigious funding agencies. HG is associate editor of J Extracell Ves, Front Physiol, Sci Rep, Int J Mol Sci and Rev Port Cardiol.
HG is specialized in cellular and molecular mechanisms involved in the regulation of protein degradation and intercellular communication, necessary for the maintenance of cell homeostasis. In particular, HG has been interested in understanding how disturbance of proteolysis, namely non-canonical functions of ubiquitin in signalling lysosomal degradation, and intercellular communication, mediated by gap junctions and exosomes, contribute to cardiovascular disorders.
. Martins-Marques T, Ribeiro-Rodrigues T, de Jager SC, Zuzarte M, Ferreira C, Cruz P, Reis L, Baptista R, Gonçalves L, Sluijter JPG, Girao H. Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes. Life Sci Alliance 2020 (doi.org7: 10.26508/lsa.202000821)
. Martins-Marques T, Catarino S, Gonçalves A, Miranda-Silva D, Gonçalves LM, Antunes PE, Coutinho G, Leite-Moreira A, Falcão-Pires I, Girao H. EHD1 Modulates Cx43 Gap Junction Remodeling Associated with Cardiac Diseases. Circ Res. 2020; 126:e97-e113.
. Santos-Ferreira C, Abreu M, Marques C, Gonçalves L, Baptista R, Girão H. MicroRNA analysis in Pulmonary Arterial Hypertension: current knowledge and challenges. JACC: Basic to Translational Science. 2020 (doi.org/10.1016/j.jacbts.2020.07.008)
. Baptista R, Marques C, J. Enguita FJ, Matafome P, Zuzarte M, Costa MC, Castro G, Monteiro P, Reis A, Pereira P, Pêgo M, Girão H. miRNA-424(322) as a new marker of disease progression in pulmonary arterial hypertension and its role in right ventricular hypertrophy by targeting SMURF1. Cardiovasc Research 2017; 2018,114:53-64
. Ribeiro-Rodrigues TM, Laundos TL, Pereira-Carvalho R, Batista-Almeida D, Pereira R, Coelho-Santos V, Silva AP, Fernandes R, Zuzarte M, Enguita FJ, Costa MC, Pinto-do-O P, Pinto MT, Gouveia P, Ferreira L, Mason JC, Pereira P, Kwak BR, Nascimento DS, Girao H. Exosomes secreted by cardiomyocytes subjected to ischemia promote cardiac angiogenesis. Cardiovasc Research 2017, 113:1338-1350
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