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Maria Filomena Botelho


I am Director of Biophysics Institute of FMUC and Leader of the Research Line Modelling in Cancer.

I’m a senior researcher with a substantial publication record in biophysics, animal models of human diseases and oncobiology (170 full text publications in peer review journals, 5 book chapter and 743 papers published in the form of abstracts in international and national journals), and experienced in coordinating and supervising (30 PhD students: 16 finished and 14 ongoing, and 42 MSc students: 32 finished and 10 ongoing) and several projects. I has participated in 23 research projects as PI and member of the research team (20) and has several national and international collaborations.

The dissemination of research results was also done through the presentation of 35 communications by invitation and 901 presentations at conferences, scientific meetings, in the form of oral presentations and posters. I was awarded with 54 prizes, 24 of which in the last five.

My academic work was spread out by pre and post-graduate studies. In undergraduate degree I teach Medical Biophysics, Biophysical Basis of Medical Imaging, Computational Models of Physiological Processes, Radiation Dosimetry and Radiation Protection, Radiobiology and Biochemistry of Image. In the postgraduate degrees I teach Biophysics, Biomedical Imaging and Animal Models of Human Diseases.

Scientific Interests:

The main topics of my research work are biophysics of ionizing radiation who includes molecular imaging, radiotherapy and the teranostic use of radiation. Radiobiology and radiation effects in terms of modelling (mathematical, in vitro and in vivo). Development of animal models for human diseases (cancer, cardiac ischemia), nuclear oncology (from molecular biology to molecular imaging). New therapeutic approaches to treat cancer are other topic of my interest.

Selected publications:

1. "Advances on photodynamic therapy of melanoma through novel ring-fused 5,15-diphenylchlorins". Pereira NAM, Laranjo M, Pina J, Oliveira ASR, Ferreira JD, Sánchez-Sánchez C, Casalta-Lopes J, Gonçalves AC, Sarmento-Ribeiro AB, Piñeiro M, Seixas de Melo JS, Botelho MF, Pinho E Melo TMVD. Eur J Med Chem. 2018;146:395-408. doi: 10.1016/j.ejmech.2017.12.093. IF: 4.519; Average percentil: 94,167; Q1: Chemistry, Medicinal.

2. "Can the regenerative potential of an alkali-free bioactive glass composition be enhanced when mixed with resorbable β-TCP?". MM Ferreira. AF Brito, CF Marques. LF Freitas, E Carrilho, AM Abrantes, AS Pires, MJ Aguiar, L Carvalho, MF Botelho. Ceramics International. 2018; 44 (5):5025-5031. IF: 2,986; Average percentil: 94,231. Q1: Materials Science, Ceramics.

3. "Ascorbic acid and colon cancer: an oxidative stimulus to cell death depending on cell profile". Pires AS, Marques CR, Encarnação JC, Abrantes AM, Mamede AC, Laranjo M, Gonçalves AC, Sarmento-Ribeiro AB, Botelho MF. European Journal of Cell Biology. 2016 Jun-Jul;95(6-7):208-18. IF: 3.712. Q1: Biochemistry, Genetics and Molecular Biology, Cell Biology

4. "New Approach for Treatment of Primary Liver Tumors: The Role of Quercetin". Brito AF, Ribeiro M, Abrantes AM, Mamede AC, Laranjo M, Casalta-Lopes JE, Gonçalves AC, Sarmento-Ribeiro AB, Tralhão JG, Botelho MF. Nutrition and Cancer. 2016;68(2):250-66. IF: 2.447. Q1: Clinical Medicine

5. "The role of immune system exhaustion on cancer cell escape and anti-tumor immune induction after irradiation". F Mendes, C Domingues, P Rodrigues-Santos, AM Abrantes, AC Gonçalves, J Estrela, J Encarnação, AS Pires, M Laranjo, V Alves, R Teixo, AB Sarmento, MF Botelho, MS Rosa. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 2016 Feb 9;1865(2):168-175. IF: 9.452. Average percentil: 94,470; Q1: Biochemistry & Molecular Biology; Biophisics.

Phone Number: +351 239 480240

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