 Mafalda Laranjo is a Post-doctoral Fellow at Faculty
of Medicine of University of Coimbra. Since she graduated in Biology, she has been
committed with cancer research. Both her MSc (Cell and Molecular Biology) dissertation
and her PhD (Health Sciences) thesis were focused on the development of
improved photosensitizers for therapy and imaging. In collaboration with
researchers from the Coimbra Chemistry Centre, new entities are synthetized and
evaluated regarding their mechanisms of action and therapeutic outcome, using
cell and molecular biology techniques and animal models of cancer. Mafalda also contributes for translational projects
applied to several medical specialties, from gynaecology to dentistry. In 2018, she is the coordinator of one
research project and participant researcher of projects with a global funding
of >2M€. Because of her participation in several research projects, she is
co-author of more than 40 full-text papers, one book chapter and one filled
patent. Mafalda often collaborates in the teaching activities
at FMUC, such as the PhD Program, the annual Course in Cell and Tissue Culture
and Laboratory Animal Science courses. Furthermore, she was supervisor or co-supervisor
of 2 BSc students, 8 MSc students (4 concluded) and 2 PhD students (ongoing). She
is an invited reviewer for oncology journals and national and international
science funding agencies. |
Scientific Interests: - Cancer, mechanisms of the disease and
research of potential new drugs and therapies
- Photodynamic
therapy and its molecular mechanisms.
- Improving photodynamic
therapy regarding double selectivity and limiting unwanted photosensitivity.
- Strategies for
optimized and targeted photosensitizer delivery.
- Photosensitizer
theragnostic applications.
- Primary cell
cultures and cellular biology.
Selected publications: - Nelson
Pereira, Mafalda Laranjo, João Pina, Andreia Oliveira, João Ferreira, Carles Sánchez-Sánchez,
João Casalta-Lopes, Ana Gonçalves, Ana Sarmento-Ribeiro, Marta Piñeiro, Sérgio
Seixas de Melo, Maria Filomena Botelho, Teresa Pinho e Melo; Advances on
photodynamic therapy of melanoma through novel ring-fused
5,15-diphenylchlorins, European Journal of Medicinal Chemistry, 2018, Volume
146, Pages 395-408, doi: 10.1016/j.ejmech.2017.12.093.
- Guilherme
Chohfi de Miguel, Ana Margarida Abrantes, Mafalda Laranjo, Ana Yoshie Kitagawa
Grizotto, Bruno Camporeze, José Aires Pereira, Gonçalo Brites, Arménio Serra,
Marta Pineiro, António Rocha-Gonsalves, Maria Filomena Botelho, Denise
Gonçalves Priolli; A new therapeutic proposal for inoperable osteosarcoma:
Photodynamic therapy, Photodiagnosis and photodynamic therapy, 2018, Volume:
21, Pages: 79-85, doi: 10.1016/j.pdpdt.2017.11.009.
- Nelson Pereira, Mafalda Laranjo, João
Casalta-Lopes, Arménio Serra, Marta Piñeiro, João Pina, Sérgio Seixas de Melo,
Mathias O. Senge, M. Filomena Botelho, Liliana Martelo, Hugh Burrows, Teresa
Pinho e Melo; Platinum(II) Ring-Fused Chlorins as Near-Infrared Emitting Oxygen
Sensors and Photodynamic Agents ACS Medicinal Chemistry Letters, 2017, Volume 8, Pages 310–315,
doi: 10.1021/acsmedchemlett.6b00476.
- Mafalda
Laranjo, Maria João Carvalho, Tânia Costa, André Alves, Rui Caetano Oliveira,
João Casalta-Lopes, Patrícia Cordeiro, Filomena Botas, Ana Margarida Abrantes,
Artur Paiva, Carlos Oliveira, Maria Filomena Botelho; Mammospheres of hormonal
receptor positive breast cancer diverge to triple-negative phenotype, The Breast,
2018, Volume 38, Pages 22-29, doi: 10.1016/j.breast.2017.11.009.
- Ana Mamede, Sara Guerra, Mafalda Laranjo,
Kathleen Santos, Maria João Carvalho, Tiago Carvalheiro, Paulo Moura, Artur
Paiva, Ana Abrantes, Cláudio Maia, Maria Filomena Botelho; Oxidative stress,
DNA, cell cycle/cell cycle associated proteins and multidrug resistance
proteins: targets of human amniotic membrane in hepatocellular carcinoma, Pathology & Oncology Research, 2016, Volume 22, Pages
689-697, doi: 10.1007/s12253-016-0053-x
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