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Mafalda Laranjo

Mafalda Laranjo

Mafalda Laranjo is a Post-doctoral Fellow at Faculty of Medicine of University of Coimbra. Since she graduated in Biology, she has been committed with cancer research. Both her MSc (Cell and Molecular Biology) dissertation and her PhD (Health Sciences) thesis were focused on the development of improved photosensitizers for therapy and imaging. In collaboration with researchers from the Coimbra Chemistry Centre, new entities are synthetized and evaluated regarding their mechanisms of action and therapeutic outcome, using cell and molecular biology techniques and animal models of cancer.

Mafalda also contributes for translational projects applied to several medical specialties, from gynaecology to dentistry. In 2018, she is the coordinator of one research project and participant researcher of projects with a global funding of >2M€. Because of her participation in several research projects, she is co-author of more than 40 full-text papers, one book chapter and one filled patent.

Mafalda often collaborates in the teaching activities at FMUC, such as the PhD Program, the annual Course in Cell and Tissue Culture and Laboratory Animal Science courses. Furthermore, she was supervisor or co-supervisor of 2 BSc students, 8 MSc students (4 concluded) and 2 PhD students (ongoing). She is an invited reviewer for oncology journals and national and international science funding agencies.

Scientific Interests:

  • Cancer, mechanisms of the disease and research of potential new drugs and therapies
  • Photodynamic therapy and its molecular mechanisms.
  • Improving photodynamic therapy regarding double selectivity and limiting unwanted photosensitivity.
  • Strategies for optimized and targeted photosensitizer delivery.
  • Photosensitizer theragnostic applications.
  • Translational medicine.
  • Animal models.
  • Primary cell cultures and cellular biology.

Selected publications:

  1.   Nelson Pereira, Mafalda Laranjo, João Pina, Andreia Oliveira, João Ferreira, Carles Sánchez-Sánchez, João Casalta-Lopes, Ana Gonçalves, Ana Sarmento-Ribeiro, Marta Piñeiro, Sérgio Seixas de Melo, Maria Filomena Botelho, Teresa Pinho e Melo; Advances on photodynamic therapy of melanoma through novel ring-fused 5,15-diphenylchlorins, European Journal of Medicinal Chemistry, 2018, Volume 146, Pages 395-408, doi: 10.1016/j.ejmech.2017.12.093.
  2. Guilherme Chohfi de Miguel, Ana Margarida Abrantes, Mafalda Laranjo, Ana Yoshie Kitagawa Grizotto, Bruno Camporeze, José Aires Pereira, Gonçalo Brites, Arménio Serra, Marta Pineiro, António Rocha-Gonsalves, Maria Filomena Botelho, Denise Gonçalves Priolli; A new therapeutic proposal for inoperable osteosarcoma: Photodynamic therapy, Photodiagnosis and photodynamic therapy, 2018, Volume: 21, Pages: 79-85, doi: 10.1016/j.pdpdt.2017.11.009.
  3. Nelson Pereira, Mafalda Laranjo, João Casalta-Lopes, Arménio Serra, Marta Piñeiro, João Pina, Sérgio Seixas de Melo, Mathias O. Senge, M. Filomena Botelho, Liliana Martelo, Hugh Burrows, Teresa Pinho e Melo; Platinum(II) Ring-Fused Chlorins as Near-Infrared Emitting Oxygen Sensors and Photodynamic Agents ACS Medicinal Chemistry Letters, 2017, Volume 8, Pages 310–315, doi: 10.1021/acsmedchemlett.6b00476.
  4. Mafalda Laranjo, Maria João Carvalho, Tânia Costa, André Alves, Rui Caetano Oliveira, João Casalta-Lopes, Patrícia Cordeiro, Filomena Botas, Ana Margarida Abrantes, Artur Paiva, Carlos Oliveira, Maria Filomena Botelho; Mammospheres of hormonal receptor positive breast cancer diverge to triple-negative phenotype, The Breast, 2018, Volume 38, Pages 22-29, doi: 10.1016/j.breast.2017.11.009.
  5. Ana Mamede, Sara Guerra, Mafalda Laranjo, Kathleen Santos, Maria João Carvalho, Tiago Carvalheiro, Paulo Moura, Artur Paiva, Ana Abrantes, Cláudio Maia, Maria Filomena Botelho; Oxidative stress, DNA, cell cycle/cell cycle associated proteins and multidrug resistance proteins: targets of human amniotic membrane in hepatocellular carcinoma, Pathology & Oncology Research, 2016, Volume 22, Pages 689-697, doi: 10.1007/s12253-016-0053-x
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