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Retinal Dysfunction & Neuroinflammation Lab

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Blockade of microglial adenosine A2A receptor impacts inflammatory mechanisms, reduces ARPE-19 cell dysfunction and prevents photoreceptor loss in vitro. Madeira MH, Rashid K, Ambrósio AF, Santiago AR, Langmann T. Sci Rep. 2018 Feb 2;8(1):2272. doi: 10.1038/s41598-018-20733-2. PMID: 29396515

Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage. Boia R, Elvas F, Madeira MH, Aires ID, Rodrigues-Neves AC, Tralhão P, Szabó EC, Baqi Y, Müller CE, Tomé ÂR, Cunha RA, Ambrósio AF, Santiago AR. Cell Death Dis. 2017 Oct 5;8(10):e3065. doi: 10.1038/cddis.2017.451. PMID: 28981089

Caveolin-1-mediated internalization of the vitamin C transporter SVCT2 in microglia triggers an inflammatory phenotype. Portugal CC, Socodato R, Canedo T, Silva CM, Martins T, Coreixas VS, Loiola EC, Gess B, Röhr D, Santiago AR, Young P, Minshall RD, Paes-de-Carvalho R, Ambrósio AF, Relvas JB. Sci Signal. 2017 Mar 28;10(472). pii: eaal2005. doi: 10.1126/scisignal.aal2005. PMID: 28351945

Caffeine administration prevents retinal neuroinflammation and loss of retinal ganglion cells in an animal model of glaucoma. Madeira MH, Ortin-Martinez A, Nadal-Nícolas F, Ambrósio AF, Vidal-Sanz M, Agudo-Barriuso M, Santiago AR. Sci Rep. 2016 Jun 8;6:27532. doi: 10.1038/srep27532. PMID: 27270337

Protective Effect of a GLP-1 Analog on Ischemia-Reperfusion Induced Blood-Retinal Barrier Breakdown and Inflammation. Gonçalves A, Lin CM, Muthusamy A, Fontes-Ribeiro C, Ambrósio AF, Abcouwer SF, Fernandes R, Antonetti DA. Invest Ophthalmol Vis Sci. 2016 May 1;57(6):2584-92. doi: 10.1167/iovs.15-19006. PMID: 27163772

Selective A2A receptor antagonist prevents microglia-mediated neuroinflammation and protects retinal ganglion cells from high intraocular pressure-induced transient ischemic injury. Madeira MH, Boia R, Elvas F, Martins T, Cunha RA, Ambrósio AF, Santiago AR. Transl Res. 2016 Mar;169:112-28. doi: 10.1016/j.trsl.2015.11.005. Epub 2015 Nov 23. PMID: 26685039

Adenosine A3 receptor activation is neuroprotective against retinal neurodegeneration. Galvao J, Elvas F, Martins T, Cordeiro MF, Ambrósio AF, Santiago AR. Exp Eye Res. 2015 Nov;140:65-74. doi: 10.1016/j.exer.2015.08.009. Epub 2015 Aug 18. PMID: 26297614

Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure. Madeira MH, Elvas F, Boia R, Gonçalves FQ, Cunha RA, Ambrósio AF, Santiago AR. J Neuroinflammation. 2015 Jun 10;12:115. doi: 10.1186/s12974-015-0333-5. PMID:26054642

c-Src function is necessary and sufficient for triggering microglial cell activation.

Socodato R, Portugal CC, Domith I, Oliveira NA, Coreixas VS, Loiola EC, Martins T, Santiago AR, Paes-de-Carvalho R, Ambrósio AF, Relvas JB. Glia. 2015 Mar;63(3):497-511. doi: 10.1002/glia.22767. Epub 2014 Nov 24. PMID: 25421817

Dipeptidyl peptidase-IV inhibition prevents blood-retinal barrier breakdown, inflammation and neuronal cell death in the retina of type 1 diabetic rats. Gonçalves A, Marques C, Leal E, Ribeiro CF, Reis F, Ambrósio AF, Fernandes R. Biochim Biophys Acta. 2014 Sep;1842(9):1454-63. doi: 10.1016/j.bbadis.2014.04.013. Epub 2014 Apr 25. PMID: 24769045