Lino Ferreira
Principal Investigator
Acrónimo | Acronym
Nome | Name
Triggerable nanomaterials to modulate cell activity.
Sobre | About
Starting Grant (StG) PE8, ERC-2012-StG_20111012 2012-11-01 - 2017-10-31 1,7 M€


Principal Investigator Lino Ferreira
Acronym Nano Trigger

Triggerable nanomaterials to modulate cell activity

ERC Type Starting Grant (StG), PE8, ERC-2012-StG_20111012
Year 2012
Value 1,7 M€
Research Unit CNC


Nano Trigger
The advent of molecular reprogramming and the associated opportunities for personalised and therapeutic medicine requires the development of novel systems for on-demand delivery of reprogramming factors into cells in order to modulate their activity/identity. Such triggerable systems should allow precise control of the timing, duration, magnitude and spatial release of the reprogramming factors. Furthermore, the system should allow this control even in vivo, using non-invasive means. The present project aims at developing triggerable systems able to release efficiently reprogramming factors on demand. The potential of this technology will be tested in two settings: (i) in the reprogramming of somatic cells in vitro, and (ii) in the improvement of hematopoietic stem cell engraftment in vivo, at the bone marrow. The proposed research involves a team formed by engineers, chemists, biologists and is highly multidisciplinary in nature encompassing elements of engineering, chemistry, system biology, stem cell technology and nanomedicine.
Start date 2012-11-01
End date 2017-10-31
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