Functional Genomics and Sequencing - UCGenomics

Cancer molecular profiles

Molecular tumour profiling can predict an individual’s prognosis by interpreting the expression pattern of a panel of tumour-related genes.

Liquid biopsy in cancer

This procedure allows to study DNA and RNA from cancer cells from a tumor that are circulating in the blood. May be used to help find cancer at an early stage and be used to help plan treatment.

Metagenomics

Investigate the microbiota composition of complex environments. This application is based on the amplification of a specific region of the 16S rRNA gene for bacteria or the ITS (Internal Transcribed Spacer) region for fungi.

Multiplex ligation-dependent probe amplification (MLPA)

This application is commonly used to identify exon-level copy number variants (CNVs) not detected by conventional sequencing.

NGS Panels

NGS panels are collections of genes that have been selected to identify a genetic cause of disease or to study regions of interest. It allows simultaneous sequencing of all the genes, in a faster and more cost-efffective way than conventional sequencing.

RNA-seq

RNA-seq allows gene expression analysis across the whole transcriptome or specifically, reveal the presence and quantity of RNA of selected genes.

Sanger Sequencing

SNVs/SNPs identification. This application is also used to identify exon-level copy number variants (CNVs).

SNVs/SNPs Genotyping

SNVs/SNPs identification.