Nano2Brain: Dual Nanostructured Lipid Carrier as a Multifunctional Platform for Brain Tumor Therapy

KEYWORDS: Nanostructured Lipid Carriers; Tumor Targeting; BBB Cross Ability; Repurposed Drugs.

The proposed invention provides a nanotechnological based platform, particularly a nanostructured lipid carrier (NLC) with a particle size lower than 200 nm, encapsulating a combination of agents aiming at brain tumor therapy. This is achieved through, but not limited to coupling tumor-specific ligands on the surface of the nanosystem to preferentially and/or specifically target cell populations such as tumor cells. Thus, the platform is able, but not limited, to preferentially deliver therapeutic and/or diagnostic agents, alone or in combination, through the blood-brain-barrier (BBB) to the brain, at the intracellular level, by receptor-mediated endocytosis. This system mediates efficient intracellular release of the encapsulated agents, increasing the concentration of the payload at the target site and reducing agent-associated adverse side-effects. Consequently, the strategy adopted by the invention promotes an improvement of the safety and efficiency for glioblastoma therapy and/or diagnostic.

Advantages

BBB crossing ability.

Tumor targeting: triple targeting approach.

High versatility.

Repurposed drugs.

Cost-effective production.

Applications

It may be subjected to modifications regarding its composition, encapsulated agents or the attached ligands, depending on its purpose: treatment and/or diagnosis, but not limited, of glioblastoma and other cancer types or other diseases, as well as other fields of application, including Cosmetic, Food Industry and Environmental Engineering.

STAGE OF DEVELOPMENT: TRL 3

IPR LEGAL STATUS: Patent Pending n.º PCT/IB2020/061452 filed on 03/12/2020.

OWNERSHIP: The rights to the technology are held by the University of Coimbra.

COLLABORATION SOUGHT: Licensing for further developments or R&D partnership.

Download

Contact

Laura Alho

IP Manager

Ana Rita Querido

Innovation Manager
This uses cookies that do not gather any personal information whatsoever. By using this website, you agree with the cookie policy.
OK, I ACCEPT