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OK, ACEITO

Amália
Maria Amália da Silva Jurado

Categoria profissional: Professora Auxiliar

Morada institucional: Departamento de Ciências da Vida
Faculdade de Ciências e Tecnologia
Universidade de Coimbra
Calçada Martim de Freitas
3000-456 Coimbra
Portugal

Gabinete: 1º Piso do Colégio de S. Bento

Telefone: +351 239 240 709

Extensão interna: 262 209

Fax: +351 239 240 701

Email: asjurado@bioq.uc.pt

Áreas de interesse:

a) Lipidomics and Biophysics, exploring different topics:
i. Membrane lipid composition and biophysical properties involved in cell malfunctioning and disease;
ii. Lipid membrane structure and dynamics in relation to drug research;
iii. Membrane lipid composition changes and membrane structure remodeling as a strategy adopted by microorganisms to adapt to environmental stresses;
iv. Interaction of non-viral drug vectors with cell membranes.

b) Biochemical toxicology, with emphasis on:
i. Development of in vitro assays for toxicity assessment as an alternative to animal use;
ii. Investigation of the molecular mechanisms underlying the cytotoxic effects of xenobiotics with interest in pharmaceutics and agrochemical industries, using different model systems;
iii. Study of the alterations of the homeostatic equilibrium of biological systems induced by membrane-active xenobiotics and nanostructures and establishment of structure-activity relationships.

Publicações mais relevantes/recentes:

Maria A. S. Fernandes, Susana P.S. Pereira, Amália S. Jurado, José B.A. Custódio, Maria S. Santos, António J.M. Moreno, Gunars Duburs and Joaquim A.F. Vicente (2008). Comparative effects of three 1,4-dihydropyridine derivatives [OSI-1210, OSI-1211 (etaftoron), and OSI-3802] on rat liver mitochondrial bioenergetics and on the physical properties of membrane lipid bilayers: relevance of the length of the alkoxyl chain in positions 3 and 5 of the DHP ring. Chemico-Biological Interactions, 173: 195-204.

J.P. Monteiro, P.J. Oliveira, A.J.M. Moreno and A.S. Jurado (2008). Disruption of Hepatic Mitochondrial Bioenergetics and Permeability Transition by the Insectice Methoprene – Relevance for Toxicological Assessment. Chemosphere, 72: 1347-1354.

João P. Monteiro, Romeu A. Videira, Manuel J. Matos, Augusto M. Dinis and Amália S. Jurado (2008). Non-selective toxicological effects of the insect juvenile hormone analogue methoprene. A membrane biophysical approach. Applied Biochemistry and Biotechnology,150: 243-257.

Susana P. S. Pereira, Maria A. S. Fernandes, João D. Martins, Maria S. Santos, António J. M. Moreno, Joaquim A. F. Vicente, Romeu A. Videira and Amália S. Jurado (2009). Toxicity assessment of the herbicide metolachlor. Comparative effects on bacterial and mitochondrial model systems. Toxicology in Vitro, 23:1585-1590.

Maria F. V. Pinto, M. Carmen Morán, M. Graça Miguel, Bjorn Lindman, Amália S. Jurado, and Alberto A. C. C. Pais (2009). Controlling the morphology in DNA condensation and precipitation. Biomacromolecules, 10: 1319-1323.

João A. S. Almeida, Eduardo F. Marques, Amália S. Jurado and Alberto A. C. C. Pais (2010). The effect of cationic gemini surfactants upon lipid membranes. An experimental and molecular dynamics simulation study. Physical Chemistry Chemical Physics, 12: 14462-14476.

Ana M. S. Cardoso, Henrique Faneca, João A. S. Almeida, Alberto A. C. C. Pais, Eduardo F. Marques, Maria C. Pedroso de Lima and Amália S. Jurado (2010). Gemini surfactant dimethylene-1,2-bis(tetradecyldimethylammonium bromide)-based gene vectors: A biophysical approach to transfection efficiency. Biochimica et Biophysica Acta, 1808: 341-351.

Amália S. Jurado, Maria A. S. Fernandes, Romeu A. Videira, Francisco P. Peixoto and Joaquim A. F. Vicente (2010). Herbicides: the Face and the Reverse of the Coin. An in Vitro Approach to the Toxicity of Herbicides. In: Herbicides and Environment, Andreas Kortekamp (Ed.), ISBN: 978-953-307-476-4, InTech, Available from: http://www.intechopen.com/articles/show/title/herbicides-the-face-and-the-reverse-of-the-coin-an-in-vitro-approach-to-the-toxicity-of-herbicides-i
João P. Monteiro, André F. Martins, Marlene Lúcio, Salette Reis, Carlos F.G.C. Geraldes, Paulo J. Oliveira and Amália S. Jurado (2011). Interaction of carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP) with lipid membrane systems: a biophysical approach with relevance to mitochondrial uncoupling. Journal of Bioenergetics and Biomembranes, 43: 287-298.

João P. Monteiro, André F. Martins, Marlene Lúcio, Salette Reis, Carlos F.G.C. Geraldes, Paulo J. Oliveira and Amália S. Jurado (2011). Nimesulide interaction with membrane model systems: are membrane physical effects involved in nimesulide mitochondrial toxicity? Toxicology in Vitro, 25: 1215-1223.

Ana M.S. Cardoso, Sara Trabulo, Ana L. Cardoso, Annely Lorents, Catarina M. Morais, Paula Gomes, Cláudia Nunes, Marlene Lúcio, Salette Reis, Kärt Padari, Margus Pooga, Maria C. Pedroso de Lima, Amália S. Jurado (2012). S4(13)-PV cell-penetrating peptide induces physical and morphological changes in membrane-mimetic lipid systems and cell membranes: Implications for cell internalization. Biochimica et Biophysica Acta, 1818: 877-888.

Sara Trabulo, Ana L. Cardoso, Ana M.S. Cardoso, Nejat Duzgunes, Amália S. Jurado and Maria C. Pedroso de Lima (2012). Cell-penetrating petide-based systems for nucleic acid delivery: a biological and biophysical approach. Methods in Enzymology, Vol. 509. DOI: 10.1016/B978-0-12-391858-1.00014-9