ANTÓNIO JOAQUIM MATOS MORENO

Categoria profissionalProfessor Associado com AgregaçãoMorada institucionalDepartamento de Ciências da Vida Faculdade de Ciências e Tecnologia Universidade de Coimbra Calçada Martim de Freitas 3000-456 CoimbraGabinetePiso 0 do Colégio de Jesus Telefone(+351) 239 240 761Extensão interna262 261Fax:(+351) 239 240 701Emailmoreno@ci.uc.ptÁreas de interesseBioenergética

Publicações mais relevantes/recentes:

Moreno A.J., Serafim T.L.M., Oliveira P.J., and Madeira V.M.C., Toxicity of carbaryl on hepatic mitochondrial bioenergetics – selective inhibition of the mitochondrial respiratory chain, Chemosphere, 66: 404-411 (2007).

Moreno A.J.M., Oliveira P.J., Nova C.D., Alvaro A.R., Moreira R.A., Santos S.M.D, Macedo T., Unaltered Hepatic Oxidative Phosphorylation and Mitochondrial Permeability Transition in Nimesulide-treated Rats - Relevance for Early Cell Markers of Nimesulide Toxicity, J. Biochem. Mol. Toxicol. 21(2): 53-61 (2007).

Moreira P.I., Custódio J.B.A., Nunes E., Moreno A.J.M., Seiça R., Oliveira C.R., Santos M.S., Estradiol affects liver mitochondrial function in ovariectomized and tamoxifen-treated ovariectomized female rats, Toxicol. Appl. Pharmacol. 221(1):102-110 (2007).

Pereira G.C., Branco A.F., Matos J.A.C., Pereira S.L., Parke D., Perkins E.L., Serafim T.L., Sardão V.A., Santos M.S., Moreno A.J.M., Holy J., and Oliveira P.J., Mitochondrially-targetted Effects of Berberine on K1735-M2 Mouse Melanoma Cells - Comparison with Direct Effects on Isolated Mitochondrial Fractions, J. Pharmacol. Exp. Therap. 323(2): 636-649 (2007).

Fernandes M.A.S., Marques R.J.F., Vicente J.A.F., Santos M.S., Monteiro P., Moreno A.J.M., and Custódio J.B.A., Sildenafil citrate concemtrations not affecting oxidative ohosphorylation depress H2O2 generation by rat heart mitochondria, Mol. Cell Biochem., 309: 77-85 (2008).

Fernandes M.A.S., Pereira S.P.S., Jurado A.S., Custódio J.B.A., Santos M.S., Moreno A.J.M., Duburs G., and Vicente J.A.F., Comparative effects of three 1,4-dihydropyridine derivatives [OSI-1210, OSI-1211 (etaftoron), and OSI-3802] on rat liver mitochondrial bioenergetics and on the physical properties of membrane lipid bilayers: relevance to the length of thealkoxyl chain in positions 3 and 5 of the DHP ring, Chem. Biol. Interact., 173 (3): 195-204 (2008).

Pupure, J., Fernandes, M.A.S., Santos M.S., Moreno, A.J.M., Kalvinsh, I., Klusa, V., Oliveira, C.R., Mitochondria as a target for mildronate’s protective effects in azidothymidine (AZT)-induced toxicity of isolated rat liver mitochondria, Cell Biochem. Function, 26 (5): 620-531 (2008).

Monteiro, J.P., Oliveira, P.J., Moreno A.J.M., Jurado A.S., Disruption of hepatic mitochondrial is not a primary mechanism for the toxicity of methoprene — relevance for toxicological assessment, Chemosphere, 72 (9): 1347-1354 (2008).

Serafim T.L., Matos J.A., Sardão V.A., Pereira G.C., Branco A.F., Pereira S.L., Parke D., Perkins E.L., Moreno A.J., Holy J., Oliveira P.J., Sanguinarine Cytotoxicity on Mouse Melanoma K1735-M2 Cells - Nuclear versus Mitochondrial Effects, Biochemical Pharmacol., 76 (11): 1459-1475 (2008).

Diana Pinto-Basto, Silva J.P., Queiroz M.J.R.P., Moreno A.J.M., and Coutinho O.P., Antioxidant activity of synthetic diarylamines: a mitochondrial and cellular approach, Mitochondrion, 9(1): 17-26 (2009).

Pereira, S.P., Fernandes, M.A., Martins, J.D., Santos, M.S., Moreno, A.J.M., Vicente, J.A., Videira, R.A., and Jurado, A.S., Toxicity assessment of the herbicide metolachlor. comparative effects on bacterial and mitochondrial model systems, Toxicology in Vitro, 23: 1585-1590 (2009).

Pereira, S.P., Pereira, G.C., Moreno, A.J.M. Oliveira, P.J. Can We Predict Drug Safety and Decrease Animal Experiments Testing by Using Isolated Mitochondria? ATLA, 37: 355-365 (2009).

Fernandes, M.A.S, Santos M.S., Moreno, A.J.M., Chernova, L., Krauze, A., Duburs, G., Vicente, J.A.F. Effects of 5-acetyl(carbamoyl)-6-methylsulfanyl-1,4-dihydropyridine-5-carbonitriles on rat liver mitochondrial function. Toxicol. in Vitro, 23: 1333-1341 (2009).

Rodrigues, A.S., Lacerda, B., Moreno, A.J.M., and Ramalho-Santos, J., Proton leak modulation in testicular mitochondria affects reactive oxygen species production and lipid peroxidation. Cell Biochem. Funct., 28 (3): 224-231 (2010).

Custódio J.B.A., Santos M.S., Gonçalves D.I.R., Moremo A.J.M., Fernandes E, Bastos M.L., Carvalho F., Vicente J.A.F., and Fernandes M.A.S. Comparative effects of 3,4-methylenedioxymethamphetamine and 4-methylthioamphetamine on rat liver mitochondrial function. Toxicology, 270: 99-105 (2010).

Moreira P.I., Custódio J.B.A., Nunes E., Oliveira P.J., Moreno A., Seiça R., Oliveira C.R., and Santos M.S., Mitochondria from distinct tissues are differently affected by 17b-estradiol and tamoxifen. J. Steroid Biochem. Mol. Biol., 123:8-16 (2011).

Mota P.C., Cordeiro M., Pereira S.P., Oliveira P.J., Moreno A.J., and Ramalho-Santos J., Differential effects of p,p´-DDE on testis and liver mitochondria: Implications for reproductive toxicology. Reprod. Toxicol., 31: 80-85 (2011).

Capítulos de Livros
Oliveira P.J., and Moreno A.J.M, Carvedilol, and hypertensive drug, protects heart mitochondria from oxidative damage (In Mitochondrial Pharmacology and Toxicology, Moreno A.J.M., editor, Transworld Research Network, India), 2006.

Moreno A.J.M., and Vicente J.A., Use of a calcium-sensitive electrode for studies on mitochondrial calcium transport. (In MITOCHONDRIAL BIOENERGETICS: Methods and Protocols, Carlos M. Palmeira and António J. Moreno (eds), Methods in Molecular Biology, Volume 810, 207-217, Springer Protocols, Humana Press, 2012.