Structure, Energetics and Reactivity

Experimental Pathology

The laboratory of Experimental Pathology is headed by António Cabrita, MD, PhD and located at Faculty of Medicine, University of Coimbra (FMUC). The group develops research and training in the experimental pathology field, namely in animal models of disease, in vitro and in vivo biocompatibility and drugs evaluation, oncobiology and complementary therapies in medicine.

Besides the focus on research, the team provides pre-graduate training in Experimental Pathology to Medicine and Dentistry students and post-graduate training in the Master in Experimental Pathology, FMUC, besides long-time collaborations with several master and PhD programs.

Group collaborations include both national (ICBAS, Egas Moniz, FMDUP, UTAD, U. Évora) and international ones (University of Recife), being the laboratory involved in the organization of several events, namely the Portuguese-Brazilian congress of Experimental Pathology, located in Coimbra every 3 years.


  • António Cabrita, MD, PhD, Skill in Experimental Pathology by the Portuguese Medical Association

  • Carlos Miguel Marto, DMD, MSc, PhD Student

  • Eduardo Costa, MSc, PhD Student

  • José Ricardo Cabeças, MSc, PhD Student

  • Ana Rute Duarte, MSc, PhD student

  • Susana Seca, PhD Student


  1. Chinese medicine functional diagnosis: An integrative insight to understand rheumatoid arthritis of the hand. Seca S, Patrício M, Kirch S, Franco G, CABRITA A, Greten H. European Journal of Integrative Medicine. 2018. 22: 10-15. doi: 0.1016/j.eujim.2018.07.005

  2. Epithelial-mesenchymal transition and microRNAs: Challenges and future perspectives in oral cancer. Domingues C, Serambeque B, Laranjo C, MARTO CM, Veiga F, Sarmento Ribeiro A, Figueiras A, Botelho MF, Dourado M. Head Neck. 2018. Aug 18. [Epub ahead of print]. doi: 10.1002/hed.25381.

  3. Direct pulp capping: what is the most effective therapy?–systematic review and meta-analysis. Paula A, Laranjo M, MARTO CM, Paulo S, Abrantes A, Casalta-Lopes J, Marques-Ferreira M, Botelho MF, Carrilho E. Journal of Evidence Dental Practice. In Press, Corrected Proof (available online 15 Feb 18). doi: 10.1016/j.jebdp.2018.02.002

  1. Evaluation of bone turnover markers and serum minerals variations for predicting fracture healing versus non-union processes in adult sheep as a model for orthopedic research. Sousa CP, Lopez-Peña M, Guzón FM, Abreu HV, Luís MR, Viegas CA, Camassa J, Azevedo JT, CABRITA AS, Reis RL, Gomes ME, Dias IR. Injury. 2017 Aug;48(8):1768-1775. doi: 10.1016/j.injury.2017.05.025

  2. Therapies for white spot lesions—a systematic review. Paula AB, Fernandes AR, Coelho AS, MARTO CM, Ferreira MM, Caramelo F, do Vale F, Carrilho E. Journal of Evidence Based Dental Practice. 2017. Mar;17(1):23-38. doi: 10.1016/j.jebdp.2016.10.003

  3. A novel platform for distributed and remote real-time monitoring of animal model behavior in a bioterium. Manso A, Martinho M, Silva H, CABRITA A, Banganho A, Machado G, Macedo M. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2017 Jul;2017:3728-3731. doi: 10.1109/EMBC.2017.8037667

  4. Prognostic factors in MNU and DMBA-induced mammary tumors in female rats. Alvarado A, Lopes AC, Faustino-Rocha AI, CABRITA AMS, Ferreira R, Oliveira PA, Colaço B. Pathol Res Pract. 2017 May;213(5):441-446. doi: 10.1016/j.prp.2017.02.014

  1. Evaluation of the effect of acupuncture on hand pain, functional deficits and health-related quality of life in patients with rheumatoid arthritis--A study protocol for a multicenter, double-blind, randomized clinical trial. SECA S, Kirch S, CABRITA AS, Greten HJ. J Integr Med. 2016 May;14(3):219-27. doi: 10.1016/S2095-4964(16)60254-6.

  1. Effects on gastric mucosa induced by dental bleaching–an experimental study with 6% hydrogen peroxide in rats. Paula AB, Dias MI, Ferreira MM, Carrilho T, MARTO CM, Casalta J, CABRITA AS, Carrilho E. Journal of Applied Oral Sciences. 2015. Oct;23(5):497-507. doi: 10.1590/1678-775720150235

  2. Perioperative morbidity and mortality in the first year of life: A systematic review (1997-2012). Catré D, Lopes MF, Viana JS, CABRITA AS. Braz J Anesthesiol. 2015 Sep-Oct;65(5):384-94. doi: 10.1016/j.bjane.2013.03.025

  3. Gastroprotective effect of Cymbopogon citratus infusion on acute ethanol-induced gastric lesions in rats. Sagradas J, Costa G, Figueirinha A, Castel-Branco MM, SILVÉRIO CABRITA AM, Figueiredo IV, Batista MT. J Ethnopharmacol. 2015 Sep 15;173:134-8. doi: 10.1016/j.jep.2015.07.001

  4. Hematogenic dissemination of triple-negative versus hormonal receptor-positive breast cancer cells. Carvalho MJ, Abrantes AM, Laranjo M, Paiva B, Torgal I, CABRITA AS, Botelho F, DE Oliveira CF. In Vivo. 2015 Jul-Aug;29(4):435-44.

  5. The role of hybrid chitosan membranes on scarring process following lumbar surgery: Post-laminectomy experimental model. Carvalho M, Costa LM, Pereira JE, Shirosaki Y, Hayakawa S, Santos JD, Geuna S, Fregnan F, CABRITA AM, Maurício AC, Varejão AS. Neurol Res. 2015 Jan;37(1):23-9. doi: 10.1179/1743132814Y.0000000414

  1. The role of hybrid chitosan membranes on scarring process following lumbar surgery: post-laminectomy experimental model. Carvalho M, Costa LM, Pereira JE, Yuki Shirosaki, Hayakawa S, Santos JD, Geuna S, Fregnan F, CABRITA A, Maurício AC, Varejão AS. Neurological Research 06/2014; 37(1):1743132814Y0000000414. doi:10.1179/1743132814Y.0000000414

  2. Periapical Inflammation Subsequent to Coronal Inoculation of Dog Teeth Root Filled with Resilon/Epiphany in 1 or 2 Treatment Sessions with Chlorhexidine Medication. Santos JM, Palma P, Ramos JC, CABRITA AS, Friedman S. Journal of endodontics 06/2014; 40(6):837-41. doi:10.1016/j.joen.2013.10.023

  3. Deficient Production of Reactive Oxygen Species Leads to Severe Chronic DSS-Induced Colitis in Ncf1/p47phox-Mutant Mice. Rodrigues-Sousa T, Ladeirinha AF, Santiago AR, Carvalheiro H, Raposo B, Alarcão A, CABRITA A, Holmdahl R, Carvalho L, Souto-Carneiro M. PLoS ONE 05/2014; 9(5):e97532. doi:10.1371/journal.pone.

  4. Movimento ortodôntico; avaliação do ligamento periodontal num estudo experimental em ratazanas Wistar adultas. Maló L, CABRITA A, Rafael A. Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilo Facial. 07/2014; doi:10.1016/j.rpemd.2014.08.001

  5. Pediatric Anesthetic During Brain Immaturity and Neurodevelopment Disorders. Catré D, Lopes MF, CABRITA AS, Viana JS. Acta Médica Portuguesa. 05/2014; 27(3):383-389

  6. Orientação do plano mandibular após distração osteogénica dento-suportada: estudo experimental no cão. do Vale F, CABRITA S, Caramelo F, Amaral M, Viegas C, Maló Abreu JL. Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilo Facial. 01/2014; doi:10.1016/j.rpemd.2013.11.004