/ Ageing Research

Nuno Raimundo Group

Nuno Raimundo Group
uc46261@uc.pt | ORCID

Activity:

Cells work as a small machine in which the different components (organelles) are coordinated with each other, as in a car. When that coordination between organelles is lost, there is development of pathologies that affect muscles (including the heart), liver, eyes, ears, and nervous system. Our goal is to understand how cellular organelles crosstalk with each other so that we can avoid diseases caused by the loss of that coordination. We use mammalian models (mouse) and cellular (human, mouse, rat) to tackle these questions and define novel therapeutic strategies to neurodegenerative, muscular and other diseases.

Relevant publications:

- A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients.
Deus CM, Pereira SP, Cunha-Oliveira T, Teixeira J, Simões RF, Cagide F, Benfeito S, Borges F, Raimundo N, Oliveira PJ.Redox Biol. 2021 Sep;45:102037. doi: 10.1016/j.redox.2021.102037. Epub 2021 Jun 8.PMID: 34147843

- Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo.
Yambire KF, Rostosky C, Watanabe T, Pacheu-Grau D, Torres-Odio S, Sanchez-Guerrero A, Senderovich O, Meyron-Holtz EG, Milosevic I, Frahm J, West AP, Raimundo N.Elife. 2019 Dec 3;8:e51031. doi: 10.7554/eLife.51031.PMID: 31793879

- Mitochondria-Lysosome Crosstalk: From Physiology to Neurodegeneration.
Deus CM, Yambire KF, Oliveira PJ, Raimundo N.Trends Mol Med. 2020 Jan;26(1):71-88. doi: 10.1016/j.molmed.2019.10.009. Epub 2019 Nov 29.PMID: 31791731

- Mitochondrial fission requires DRP1 but not dynamins.
Fonseca TB, Sánchez-Guerrero Á, Milosevic I, Raimundo N.Nature. 2019 Jun;570(7761):E34-E42. doi: 10.1038/s41586-019-1296-y. Epub 2019 Jun 19.PMID: 31217603

- Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis.
Fernandez-Mosquera L, Yambire KF, Couto R, Pereyra L, Pabis K, Ponsford AH, Diogo CV, Stagi M, Milosevic I, Raimundo N.Autophagy. 2019 Sep;15(9):1572-1591. doi: 10.1080/15548627.2019.1586256. Epub 2019 Mar 27.PMID: 30917721

- Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases.
Yambire KF, Fernandez-Mosquera L, Steinfeld R, Mühle C, Ikonen E, Milosevic I, Raimundo N.Elife. 2019 Feb 18;8:e39598. doi: 10.7554/eLife.39598.PMID: 30775969

- Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness.
Raimundo N, Song L, Shutt TE, McKay SE, Cotney J, Guan MX, Gilliland TC, Hohuan D, Santos-Sacchi J, Shadel GS.Cell. 2012 Feb 17;148(4):716-26. doi: 10.1016/j.cell.2011.12.027.PMID: 22341444

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