Nano2Brain: Dual Nanostructured Lipid Carrier as a Multifunctional Platform for Brain Tumor Therapy

KEYWORDS: BBB Cross Ability; Nanostructured Lipid Carriers; Repurposed Drugs; Tumor Targeting.

The proposed invention provides a nanotechnological based platform, particularly a nanostructured lipid carrier (NLC) with a particle size lower than 200 nm, encapsulating a combination of agents aiming at brain tumor therapy. This is achieved through, but not limited to coupling tumor-specific ligands on the surface of the nanosystem to preferentially and/or specifically target cell populations such as tumor cells. Thus, the platform is able, but not limited, to preferentially deliver therapeutic and/or diagnostic agents, alone or in combination, through the blood-brain-barrier (BBB) to the brain, at the intracellular level, by receptor-mediated endocytosis. This system mediates efficient intracellular release of the encapsulated agents, increasing the concentration of the payload at the target site and reducing agent-associated adverse side-effects. Consequently, the strategy adopted by the invention promotes an improvement of the safety and efficiency for glioblastoma therapy and/or diagnostic.

Advantages

BBB crossing ability.

Tumor targeting: triple targeting approach.

High versatility.

Repurposed drugs.

Cost-effective production.

Applications

It may be subjected to modifications regarding its composition, encapsulated agents or the attached ligands, depending on its purpose: treatment and/or diagnosis, but not limited, of glioblastoma and other cancer types or other diseases, as well as other fields of application, including Cosmetic, Food Industry and Environmental Engineering.

STAGE OF DEVELOPMENT: TRL 3

IPR LEGAL STATUS: Patent Pending n.º PCT/IB2020/061452 filed on 03/12/2020.

OWNERSHIP: The rights to the technology are held by the University of Coimbra.

COLLABORATION SOUGHT: Licensing for further developments or R&D partnership.

Download

Contact

Laura Alho

IP Manager

Ana Rita Querido

Innovation Manager
Este site utiliza cookies para lhe proporcionar uma melhor experiência de utilização. Ao navegar aceita a política de cookies.
OK, ACEITO