Radiation Physics and Biology at cellular level: towards the optimization of clinical dosimetry
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Abstract
The Cell.DOT project introduces an innovative approach to enhance clinical dosimetry in targeted radiation therapies (TRT), including radiopharmaceutical therapy (RPT) and radiosensitization therapy (RST). Unlike external beam radiotherapy, which uses absorbed dose-based prescriptions, TRT is still applied using fixed activity levels, disregarding patient-specific variability. Cell.DOT aims to overcome this “one-size-fits-all” approach by developing accurate methods to estimate the distribution and biological effects of radiation at the cellular and subcellular levels.
To achieve this, Cell.DOT combines physico-chemical modeling, advanced imaging, and 3D biology using cellular spheroids that replicate metastatic niches. The goal is to reliably predict biological responses under various TRT conditions, reducing uncertainties in dosimetry and improving treatment safety and efficacy. The project’s main beneficiaries include medical physicists and radiation oncologists in the short term, and cancer patients in the medium to long term.
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Funding entity: FCT Start date: 01/2025 End date: 12/2027 Total funding: 249.782,40€ Coordinated by: IST-ID, ASSOCIAÇÃO DO INSTITUTO SUPERIOR TÉCNICO PARA A INVESTIGAÇÃO E O DESENVOLVIMENTO Consortium: University of Coimbra, Instituto Politécnico do Porto, IST-ID, Associação do Instituto Superior Técnico para a Investigação e o Desenvolvimento, LIP, Laboratório de Instrumentação e Física Experimental de Partículas – Associação para a Investigação e o Desenvolvimento PI UC: Ana Salomé Pires Lourenço |
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