mitoSKIN 2.0

Abstract

The overall objective of this proof of concept is to demonstrate the efficacy of AntiOXBEN2, an innovative antioxidant molecule with the ability to selectively accumulate in mitochondria, as an active ingredient for cosmetic applications aimed at preventing skin aging. This molecule, developed over a decade of scientific research at the University of Coimbra (UC), in partnership with the University of Porto and the company MitoTAG, acts directly on mitochondria, promoting their functionality and mitigating oxidative stress, one of the main factors underlying skin aging. The project also aims to further optimize the efficacy of AntiOXBEN2 through its encapsulation in advanced delivery systems, such as liposomes and nanoemulsions, ensuring higher stability, bioavailability, and targeted action. At the same time, this project will contribute to generating value for the start-up MitoTAG, paving the way for the development of a second line of innovative products, strengthening competitiveness in the cosmetics market and promoting the translation of science into practical applications.