N(DR)2_Eye

Abstract

Diabetic retinopathy (DR) is a major complication of diabetes and a leading cause of vision loss globally. With nearly all type 1 and over half of type 2 diabetic patients developing DR within 20 years of diagnosis, the social and economic burden is rapidly growing. This project explores the role of the Ndr2 kinase—an evolutionarily conserved regulator of inflammation, cytoskeletal dynamics, and cellular communication—in the pathogenesis of DR.

Building on promising preliminary data, we aim to uncover how Ndr2 influences inflammation, microglial behavior, and vascular integrity in the diabetic retina. Using a multidisciplinary approach that combines gene-editing, in vitro studies, in vivo models, and molecular biology, we will investigate Ndr2's involvement in oxidative stress, cytoskeletal remodeling, and extracellular vesicle-mediated communication between microglial and endothelial cells.

Our goal is to identify early molecular markers and novel therapeutic targets to prevent or mitigate DR. The project also promotes public awareness through an interactive virtual reality application and outreach initiatives. Aligned with UN Sustainable Development Goals, this research will contribute to healthier lives and help reduce the economic impact of diabetic blindness.