PAS GRAS

Abstract

PAS GRAS has the following specific objectives: i) Identify metabolic, lifestyle, mental, environmental, and socioeconomic vulnerabilities associated with increased risk of obesity development and its complications, e.g., transgenerational and food insecurity risks within families; ii) Identify (epi)genetic and gender-specific parameters in early life predicting future risk for obesity development; iii) Identify and characterize novel biological pathways and circulating markers of obesity comorbidities. Assess the systemic communication between brain and peripheral organs to unravel its decisive role in obesity development across ages and stages of disease; iv) Design and validate pharmacological strategies based on naturally-occurring compounds that will guide interventions young adults with obesity and their children, reducing the intrafamiliar risks; v. Generate participatory, creative and engaging science-health literacy tools and physical activity programs and testing their efficacy from individual to community levels towards best practices and recommendations that incorporate social and gender equity, solidarity, inclusion, and human rights. The Phytochemicals, Metabolism and Disease (Plants4Health) group is involved in the Phytochemicals Task Force, in the Nutrition Task Force and in the literacy activities