Retinal Dysfunction & Neuroinflammation Lab
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Retinal degenerative diseases (diabetic retinopathy, glaucoma and age-related macular degeneration) are a major interest. Our objetive is to give insight into the molecular and cellular mechanisms underlying these pathologies. We aim to understand how neuroinflammation mediated by microglial cells, the immune cells of the central nervous system, and how the crosstalk between different retinal cell types contribute for retinal vascular and neural dysfunction and degeneration. Other goals are to identify novel drug targets and biomarkers, as well as to develop new advanced therapies, such as controlled drug release systems, as for example light-activated nanoparticles.
The concept 'The retina as a window to the brain', in the context of Alzheimer's disease (AD), is another interest. There are many missing links regarding the changes occuring in the retina and different brain areas and we want to understand how these changes can be correlated, not only to better understand AD, but also to identify early disease biomarkers.