Cannabis - Interactions
Cannabis is made up of several chemical compounds, including Cannabidiol (CBD) and Tetrahydrocannabinol (THC), which affect the Central Nervous System (CNS), which can cause various types of interactions with other drugs (medicines or bioactive molecules with therapeutic activity), or with enzymatic complexes or glycoproteins.
Both the CBD as THC will interact with the family of enzymes of the cytochrome P450 (CYP450), to the extent that THC and CBD are metabolized in the CYP3A4, CYP2C9 and 2C19. Inhibitors of these isoenzymes slightly increase THC levels, and the inducers slightly decrease THC and CBD levels. However, THC and CBD inhibit CYPs 2A6, 3A4, 1B1, 2B6, 2C9 and 2D6. The main interactions described include the drugs: alprazolam, cyanocobalamin, clobazam, clonazepam, morphine, pregabalin, sertraline, theophylline, tramadol and warfarin. CBD can also inhibit P-glycoprotein (P-gp) and change the transport of drugs that use it.
Bibliography:
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https://www.ncbi.nlm.nih.gov/pubmed/8466552
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https://www.ncbi.nlm.nih.gov/pubmed/21704641
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https://www.ncbi.nlm.nih.gov/pubmed/17303175
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https://www.ncbi.nlm.nih.gov/pubmed/21356216
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https://www.researchgate.net/publication/286964899_Cannabinoids_and_Cytochrome_P450_Interactions