/ Research
OCT4BRAIN
Non-invasive optical coherence tomography towards the imaging of the neurodegenerative disease: from the animal retina to the human brain.
AIM
Texture analysis of the ocular fundus imaging using a non-invasive imaging technique, optical coherence tomography (OCT), may provide new insights into the pathophysiology of the neurodegenerative disease. In this project, animals models of the healthy ageing and animal models of the Alzheimer's disease (AD) will be used to inform on the early changes as imaged by OCT before any structural damages can be detected. Texture based biomarkers found from the animal retina, for the healthy ageing and AD onset/progression, will be tested on human data to establish the link and the very early signs of disease onset.
- STARTING DATE: 1 August 2018
- DURATION: 36 Months
- TOTAL BUDGET: 216.279,95
Team
Outputs
- H. Ferreira, P. Serranho, P. Guimaraes, R. Trindade, J. Martins, P.I. Moreira, A.F. Ambrosio, M. Castelo-Branco, R. Bernardes, " Stage-independent biomarkers for Alzheimer's disease from the living retina: an animal study", Scientific Reports, 12, 13667, 2022. doi: https://doi.org/10.1038/s41598-022-18113-y
- P. Guimaraes, P. Serranho, J. Martins, P.I. Moreira, A.F. Ambrosio, M. Castelo-Branco, R. Bernardes, "Retinal aging in 3×Tg-AD mice model of Alzheimer's disease", Frontiers in Aging Neuroscience, 14, 832195, 2022. doi: https://doi.org/10.3389/fnagi.2022.832195
- R. Boia, P. A. N. Dias, C. Galindo-Romero, H. Ferreira, I. D. Aires, M. Vidal-Sanz, M. Agudo-Barriuso, R. Bernardes, P. F. Santos, H. C. de. Sousa, A. F. Ambrósio, M. E. M. Braga, and A. R. Santiago, "Intraocular implants loaded with A3R agonist rescue retinal ganglion cells from ischemic damage," Journal of Controlled Release, 343, pp. 469–481, 2022. doi: https://doi.org/10.1016/j.jconrel.2022.02.001
- M. K. Ghalati, A. Nunes, H. Ferreira, P. Serranho, and R. Bernardes, "Texture analysis and its application in biomedical imaging: A survey", IEEE Reviews in Biomedical Engineering, 15, pp. 222-246, 2022. doi: 10.1109/RBME.2021.3115703
- H. Ferreira, J. Martins, P. I. Moreira, A. F. Ambrósio, M. Castelo-Branco, P. Serranho, and R. Bernardes, "Longitudinal normative OCT retinal thickness data for wild-type mice, and characterization of changes in the 3xTg- AD mice model of Alzheimer's disease", Aging13, 2021. doi: 10.18632/aging.202916
- H. Ferreira, J. Martins, A. Nunes, P. I. Moreira, M. Castelo-Branco, A. F. Ambrósio, P. Serranho, and R. Bernardes, "Characterization of the retinal changes of the 3×Tg- AD mouse model of Alzheimer’s disease", Health and Technology, pp. 1–9, 2020. doi: 10.1007/s12553-020-00413-w.
- R. Bernardes, H. Ferreira, P. Guimaraes, and P. Serranho, "Shedding light on early central nervous system changes for Alzheimer's disease through the retina: An animal study", in Proceedings of the 2nd International Conferences on Image Processing and Vision Engineering (IMPROVE), SciTePress, 2022, pp. 247-258, isbn: 978-989-758-563-0. doi: 10.5220/0011125600003209.
- H. Ferreira, J. Martins, A. Nunes, P. I. Moreira, M. Castelo-Branco, A. Ambrósio, P. Serranho, and R. Bernardes, (2019). "Characterization of the retinal changes of the 3xTg-AD mouse model of Alzheimer’s disease", XV Mediterranean Conference on Medical and Biological Engineering and Computing – MEDICON 2019, Proceedings of MEDICON 2019, September 26-28, 2019, Coimbra, Portugal. pp. 1816-1821. https://doi.org/10.1007/978-3-030-31635-8_220
- A. Nunes, A. F. Ambrosio, M. Castelo-Branco, and R. Bernardes, “Texture biomarkers of Alzheimer’s disease and disease progression in the mouse retina,” in IEEE 18th International Conference on Bioinformatics and Bioengineering (BIBE), Oct. 2018, pp. 41-46, isbn: 9781538662168. doi: 10.1109/BIBE.2018.00016.
- R. Bernardes, M. K. Ghalati, H. Ferreira, J. Martins, P. Guimaraes, P. I. Moreira, A. Ambrósio, M. Castelo-Branco, and P. Serranho, "Longitudinal OCT texture analysis to assess the retinal changes in the triple-transgenic mouse model of Alzheimer’s disease", EVER – 23rd European Association for Vision and Eye Research. Valencia, Spain, Oct. 2022.
- P. Serranho, E. Valentim, H. Ferreira and R. Bernardes, '' SVM classifier based on texture analysis for OCT retina images from mice'', SIAM Conference on Imaging Science 2020, held online, July 6-17, 2020. Abstract.
- R. Bernardes, H. Ferreira, J. Martins, P. Moreira, A. F. Ambrósio, M. Castelo-Branco, and P. Serranho, "Characterization of the retina of the triple-transgenic mice model of Alzheimer’s disease: Onset and progression of the disease", AAN – 72nd American Academy of Neurology. Toronto, Canada – Cancelled (COVID-19 Pandemic), Apr. 2020. Neurology Apr 2020, 94 (15 Supplement) 898.
- R. Bernardes, H. Ferreira, J. Martins, P. I. Moreira, M. Castelo-Branco, A. F. Ambrósio, and P. Serranho, "Retinal thickness of the triple-transgenic mice model of Alzheimer’s disease at the age of one month", EVER – 21st European Association for Vision and Eye Research. Nice, France, Oct. 2019.
- R. Bernardes, "The ageing retina of wild-type and mouse model of Alzheimer’s disease", (Invited talk) EVER – 23rd European Association for Vision and Eye Research. Valencia, Spain, Oct. 2022.
- R. Bernardes, "Machine learning approaches using OCT", EVER – 23rd European Association for Vision and Eye Research. Valencia, Spain, Oct. 2022.
- R. Bernardes, H. Ferreira, P. Guimaraes, and P. Serranho, "Shedding light on early central nervous system changes for Alzheimer's disease through the retina: An animal study", IMPROVE – 2nd International Conference on Image Processing and Vision Engineering, (Online) Apr. 2022.
- R. Bernardes, "The Retina as a Window into the Brain", EVER – European Association for Vision and Eye Research, (Webinar) Feb. 2022.
- R. Bernardes and M. Castelo-Branco, "Optical coherence tomography – machine learning", EVER – 21st European Association for Vision and Eye Research. Nice, France, Oct. 2019.
- R. Bernardes, "Optical coherence tomography: A window into the mechanism of neurodegenerative disorders", MEDICON 2019 – XV Mediterranean Conference on Medical and Biological Engineering and Computing. Coimbra, Portugal, Sep. 2019.
- H. Ferreira, J. Martins, A. Nunes, P. I. Moreira, M. Castelo-Branco, A. F. Ambrósio, P. Serranho, and R. Bernardes, "Characterization of the retinal changes of the 3xTg-AD mouse model of Alzheimer’s disease", MEDICON 2019 – XV Mediterranean Conference on Medical and Biological Engineering and Computing. Coimbra, Portugal, Sep. 2019.
- R. Bernardes, A. Nunes, A. F. Ambrósio, and M. Castelo-Branco, “Texture biomarkers of Alzheimer’s disease and disease progression in the mouse retina,” IEEE BIBE 2018 – The 18th IEEE International Conference on Bioinformatics and Bioengineering. Taichung, Taiwan, Oct. 2018.
- Special Interest Symposium - The retina as a window into the brain, EVER– 23rd European Association for Vision and Eye Research. Valencia, Spain, Oct. 2022.
- Special Session – Developments in Imaging for Ocular and Neurodegenerative Disorders (Imaging4OND), IMPROVE – 2nd International Conference on Image Processing and Vision Engineering. (Online) Apr. 2022.
- Special Session – The Retina as a Window into the Brain, EVER – European Association for Vision and Eye Research. (Webinar) Feb. 2022.
- Special Session – Ocular Imaging, MEDICON – 15th Mediterranean Conference on Medical and Biological Engineering and Computing. Coimbra, Portugal, Sep. 2019.
- Manuel Cardoso Amaral. "Técnicas de análise de textura para processamento de imagem". Master in Statistics, Mathematics and Computation (Universidade Aberta), 2022. Supervisor: Pedro Serranho. Co-Supervisor: Rui Bernardes
- Rita Caetano Trindade. "Identification of changes in retinal images of animal models of Alzheimer's disease using a deep learning approach". Master in Biomedical Engineering (University of Coimbra), 2021. Supervisor: Rui Bernardes. Co-Supervisor: Pedro Serranho
- Érick Braga Valentim. "Aplicação de Máquinas de Vector Suporte para classificação de ratos transgénicos através de imagem da retina". Master in Statistics, Mathematics and Computation (Universidade Aberta), 2020. Supervisor: Pedro Serranho. Co-Supervisor: Rui Bernardes
- Ferreira, H. Young Investigator Competition Award, MEDICON, Coimbra, Portugal
FUNDINGS
IC&DT project (PTDC/EMD-EMD/28039/2017) funded by FCT
