Kinder-GUT

Acrónimo: Kinder-GUT

Objetivo temático: Elucidating how the intestinal immune system acts at mucosal barrier, will bring essential knowledge to understand mucosal surveillance in intestinal homeostasis and in response to pathogen infection.

Área Científica: Infectious disease

Síntese do Projeto: The propose of the project is that diet-derived retinoids regulate CD8αα IEL and underlie their intestinal function. By combining tissuespecific loss of function and reporter mouse models, RNA sequencing, retroviral transduction and 3D organoid assays , we will elucidate the molecular and cellular pathways underlying RA signaling in CD8αα IELs, their immune function and explore these new axes in CD8αα IELs. These will establish a molecular axis between dietary cues and CD8αα IEL and will generate breakthrough findings in the next 3 years paving the way for new therapeutic targets in gastrointestinal infections.

Área de intervenção: Immunity and infection

Investigador Responsável na UC: Manuela Ferreira

Unidade Orgânica UC: Reitoria - CNC

Instituições participantes no Projeto: UC

Instituição Financiadora/Gestora: Fundação La Caixa

Programa de Financiamento: Caixa Research Health 2022

Período de execução: De 01/12/2022 a 30/11/2025 (36 meses)

Custo total elegível (EUR): 408 077,71 €

Técnico do Projeto: Maria Joana Dias

Contacto:: 239247026