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The Protein Biophysical Chemistry Group has a wide range of publications across different research areas.
Chaves, O. A., Loureiro, R. J., Costa-Tuna, A., Almeida, Z. L., Pina, J., Brito, R. M., Serpa, C., Interaction of Two Commercial Azobenzene Food Dyes, Amaranth and New Coccine, with Human Serum Albumin: Biophysical Characterization. ACS Food Science & Technology 3(5), 955-968, 2023.
Cunha, A. E. S., Loureiro, R. J. S., Simões, C. J. V., Brito, R. M. M., Unveiling New Druggable Pockets in Influenza Non-Structural Protein 1: NS1-Host Interactions as Antiviral Targets for Flu. Int J Mol Sci., 24(3), 2977.
Khalighi, S., Jalkh, J., Cruz, P. F., Brito, R. M. M., Santos, J. B., & Ferreira, A. G. M. Influence of Pressure and Temperature in the Speed of Sound of Isobutanol + Biodiesel Mixtures. Journal of Chemical and Engineering Data, 68(8).
Mata, A. I., Pereira, N. A. M., Cardoso, A. L., Nascimento, B. F. O., Pineiro, M., Schaberle, F. A., Gomes-da-Silva, L. C., Brito, R. M. M., Melo, T. M. V. D., Novel Foscan®-derived ring-fused chlorins for photodynamic therapy of cancer. Bioorg Med Chem., 93, 117443.
Abbasi M, Santos BP, Pereira TC, Sofia R, Monteiro NRC, Simões CJV, Brito RMM, Ribeiro B, Oliveira JL, Arrais JP. (2022). Designing optimized drug candidates with Generative Adversarial Network. J. Cheminform., 14, 40.
Almeida ZL, Brito RMM. (2022). Amyloid Disassembly: What Can We Learn from Chaperones?, Biomedicines, 10, 3276.
Conde-Giménez M, Galano-Frutos JJ, Galiana-Cameo M, Mahía A, Victor BL, Salillas S, Velázquez-Campoy A, Brito RMM, Gálvez JA, Díaz-de-Villegas MD, Sancho J. (2022). Alchemical Design of Pharmacological Chaperones with Higher Affinity for Phenylalanine Hydroxylase. Int. J. Mol. Sci., 23, 4502.
Ferreira AGM, Santos JB, Jalkh J, Khalighi S, Cruz PF, Brito RMM. (2022). Pressure Effect on the Speed of Sound of Waste Cooking Oil Biodiesel. J. Chem. Eng. Data, 67, pp 3046–3058
Ferreira E, Almeida ZL, Cruz PF, Sousa M, Verissimo P, Brito RMM. (2022). Searching for the Best Transthyretin Aggregation Protocol to Study Amyloid Fibril Disruption. Int. J. Mol. Sci. , 23, 391.
Luís JP, Mata AI, Simões CJV, Brito RMM. (2022). Conformational Dynamics of the Soluble and Membrane-Bound Forms of Interleukin-1 Receptor Type-1: Insights into Linker Flexibility and Domain Orientation. Int. J. Mol. Sci., 23, 2599.
Luís JP, Simões CJV, Brito RMM. (2022). The Therapeutic Prospects of Targeting IL-1R1 for the Modulation of Neuroinflammation in Central Nervous System Disorders. Int. J. Mol. Sci. 23, 1731.
Primitivo MJ, Neves M, Pires CL, Cruz PF, Brito C, Rodrigues AC, de Carvalho CCCR, Mortimer MM, Moreno MJ, Brito RMM, Taylor EJ, Millson SH, Reboredo F, Campos MJ, Vaz DC, Ribeiro VS. (2022). Edible flowers of Helichrysum italicum: Composition, nutritive value, and bioactivities. Food Research International, 157, 111399.
Trigueiro-Louro J, Santos LA, Almeida F, Correia V, Brito RMM, Rebelo-de-Andrade H. (2022). NS1 protein as a novel anti-influenza target: Map-and-mutate antiviral rationale reveals new putative druggable hot spots with an important role on viral replication. Virology, 565, pp 106-116.
Brito C, Bertotti T, Primitivo MJ, Neves M, Pires CL, Cruz PF, Martins PAT, Rodrigues AC, Moreno MJ, Brito RMM, Campos MJ, Vaz DC, Pessoa MF, Lidon F, Reboredo F, Ribeiro VS. (2021). Corema album spp: Edible wild crowberries with a high content in minerals and organic acids. Food Chem. 345:128732.
Ferreira AGM, Santos JB, Baptista J, Khalighi S, Brito RMM, Cruz PF. (2021). Effect of Isobutanol Addition on the Biodiesel Density. J. Chem. Eng. Data, 66, 12, pp 4542–4562
Adão R, Cruz PF, Vaz DC, Fonseca F, Pedersen JN, Ferreira-da-Silva F, Brito RMM, Ramos CHI, Otzen D, Keller S, Bastos M. (2020). DIBMA nanodiscs keep α-synuclein folded. Biochim Biophys Acta Biomembr. 1862(9):183314.
Almeida ZL, Brito RMM. (2020). Structure and Aggregation Mechanisms in Amyloids. Molecules. 25(5):1195.
Alves NG, Mata AI, Luís JP, Brito RMM, Simões CJV. (2020). An Innovative Sequence-to-Structure-Based Approach to Drug Resistance Interpretation and Prediction: The Use of Molecular Interaction Fields to Detect HIV-1 Protease Binding-Site Dissimilarities. Front Chem. 8:243.
Frangolho A, Correia BE, Vaz DC, Almeida ZL, Brito RMM. (2020). Oligomerization Profile of Human Transthyretin Variants with Distinct Amyloidogenicity. Molecules. 25(23):5698.
Gierlich P, Mata AI, Donohoe C, Brito RMM, Senge MO, Gomes-da-Silva LC. (2020). Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment. Molecules. 25(22):5317.
Rosário-Ferreira N, Preto AJ, Melo R, Moreira IS, Brito RMM. (2020). The Central Role of Non-Structural Protein 1 (NS1) in Influenza Biology and Infection. Int J Mol Sci. 21(4):1511
Bezerra F, Simões CJV, Beirão JM, Saraiva MJ, Brito RMM, Almeida MR. (2019). Targeting transthyretin amyloidosis in the eye with next-generation stabilizers: AT40 displays potent TTR stabilization in the human vitreous. Amyloid 26(sup1):73-74.
Simões CJV, Almeida ZL, Cardoso AL, Bezerra F, Almeida MR, Beirão J, Pinho E Melo TMVD, Saraiva MJ, Brito RMM. (2019). Lead optimization of resilient next-generation transthyretin stabilizers for multiple target-product profiles: approaching the CNS. Amyloid. 26(sup1):77-78.
Trigueiro-Louro JM, Correia V, Santos LA, Guedes RC, Brito RMM, Rebelo-de-Andrade H. (2019). To hit or not to hit: Large-scale sequence analysis and structure characterization of influenza A NS1 unlocks new antiviral target potential. Virology. 535:297-307.
Jesus CSH, Cruz PF, Arnaut LG, Brito RMM, Serpa C.J (2018). One Peptide Reveals the Two Faces of α-Helix Unfolding-Folding Dynamics. Phys Chem B. 122(14):3790-3800.
Jorge, M., Garrido, N.M., Simões, C.J.V., Silva, C.G., Brito, R.M.M. (2017) "Predicting hydrophobic solvation by molecular simulation: 1. Testing united-atom alkane models", J. Comput. Chem. 38(6), pp. 346–358 (Epub 2016 Dec 28).
Chaves, O.A., Jesus, C.S.H., Cruz, Henriques, E.S., Brito, R.M.M., Serpa, C. (2016) "In-situ ultra-fast heat deposition does not perturb serum albumin structure", Photochem. Photobiol. Sci. 15(12), pp. 1524-1535 (Epub 2016 Oct 24).
Manco, L., Bento, C,, Victor, B.L., Pereira, J., Relvas, L., Brito, R.M.M., Seabra, C., Maia, T.M., Ribeiro, M.L. (2016) "Hereditary nonspherocytic hemolytic anemia caused by red cell glucose-6-phosphate isomerase (GPI) deficiency in two Portuguese patients: Clinical features and molecular study". Blood Cells Mol. Dis. 60, pp. 18-23. (Epub 2016 Jun 11).
Jesus, C.S.H., Almeida, Z.L., Vaz, D.C., Faria, T.Q., Brito, R.M.M. (2016) "A New Folding Kinetic Mechanism for Human Transthyretin and the Influence of the Amyloidogenic V30M Mutation". Int. J. Mol. Sci. 17(9), 1428.
Silva, C.G., Simões, C.J.V., Carreiras, P., Brito, R.M.M. (2016) "Enhancing Scoring Performance of Docking-Based Virtual Screening Through Machine Learning". Current Bioinformatics 11 (4), pp. 408-420.
Chaves, O.A., Jesus, C.S.H., Cruz, P.F., Sant'Anna, C.M.,
Brito, R.M.M., Serpa, C. (2016) "Evaluation by fluorescence, STD-NMR, docking and semi-empirical calculations of the o-NBA photo-acid interaction with BSA". Spectrochim Acta A Mol Biomol Spectrosc. 169, pp. 175-181 (Epub 2016 June 18.).
Magalhães, S.S., Alves, L., Sebastião, M, Medronho, B, Almeida, Z.L., Faria, T.Q., Brito R.M.M., Moreno, M.J., Antunes F.E. (2016) "Effect of ethyleneoxide groups of anionic surfactants on lipase activity". Biotechnol Prog. (Epub 2016 June 19.).
Simões, C.J.V., Almeida, Z.L., Costa, D., Jesus, C.S.H., Cardoso, A.L., Almeida, M.R., Saraiva, M.J., Pinho e Melo, T.M.V.D., Brito, R.M.M. (2016) "A novel bis-furan scaffold for transthyretin stabilization and amyloid inhibition". European Journal of Medicinal Chemistry 121, pp. 823–840. (Epub 2016 March 3.).
Dias, D.M., Furtado, J., Wasielewski, E., Cruz, R., Costello, B., Cole, L., Faria, T.Q., Baaske, P., Brito, R.M.M., Ciulli, A., Simões, I., Macedo-Ribeiro, S., Faro, C., Geraldes, C.F.G.C., Castanheira, P. (2016). "Biophysical characterization of laforin–carbohydrate interaction". Biochem. J. 473, pp. 335–345 (Epub 2015 November 17.).
Silva, C.G., Monteiro, A., Manahl, C., Lostal, E., Schäfer, T., Andrade, N., Brasileiro, F., Mota, P.G., Serrano, F., Carrodeguas, J. A., Brito, R. M. M. (2016). "Cell Spotting: educational and motivational outcomes of cell biology citizen science project in the classroom". JCOM 15 (01), A02.
Vilaça, H., Pereira, G., Castro, T.G., Hermenegildo, B.F., Shi, J., Faria, T.Q., Micaêlo, N., R.M.M. Brito, Xu, B., Castanheira, E.M.S., Martins, J.A., Ferreira, P.M.T. (2015). "New self-assembled supramolecular hydrogels based on dehydropeptides". J. Mater. Chem. B 3, pp. 6355-6367.
Faria, T.Q., Almeida, Z.L., Cruz, P.C., Jesus, C.S.H., Castanheira, P., Brito, R.M.M. (2015). "A look into amyloid formation by transthyretin: aggregation pathway and a novel kinetic model". Phys. Chem. Chem. Phys. 17, pp. 7255-7263 (Epub 2015 Feb 4.).
Silva, C.G., Brito, R.M.M., Monteiro, A., Leal, J.A.F., Furtado, A., Andrade, N., Brasileiro, F., Mota, P.G., Manahl, C., Holocher-Ertl, T., Pérez, M., Lostal, E., Val, C., Sanz, F., Serrano, F. (2014). "SOCIENTIZE participatory experiments, dissemination and networking activities in perspective", Human Computation 1 (2), pp. 119-135.
Sousa, J., Brito, R.M.M., Salvador, J.A.R., Silva, C.G. (2014). "In Search of Predictive Models for Inhibitors of 5-alpha Reductase 2 Based on the Integration of Bioactivity and Molecular Descriptors Data", Proceedings of the IWBBIO 2014 - 2nd International Work-Conference on Bioinformatics and Biomedical Engineering. Granada, Spain, Vol. 1, pp. 463-472.
Silva, C.G., Carreiras, P., Henriques, E.S., Simões, C.J.V., Brito, R.M.M. (2014). "A Machine Learning Approach to Enhance Scoring Performance in Docking-Based Virtual Screening Experiments: COX-1 as a Case Study", Proceedings of the IWBBIO 2014 - 2nd International Work-Conference on Bioinformatics and Biomedical Engineering. Granada, Spain, Vol. 1, pp. 406-414.
Mompeán, M., Buratti, E., Guarnaccia, C., Brito, R.M.M., Chakrabartty, A., Baralle, F.E., Laurents, D.V. (2014). "Structural characterization of the minimal segment of TDP-43 competent for aggregation", Archives of Biochemistry and Biophysics 545, pp. 53–62.
Jesus, C.S.H., Vaz, D.C., Saraiva, M.J.M., and Brito, R.M.M. (2013). "The V30M amyloidogenic mutation decreases the rate of refolding kinetics of the tetrameric protein transthyretin", Advances in Biomedical Spectroscopy, vol. 7, pg. 267-271, IOS Press (ISBN: 978-1-61499-183-0).
Toubarro, D., Avila, M.M., Hao, Y.J., Balasubramanian, N., Jing, Y., Montiel, R., Faria, T.Q., Brito, R.M.M., and Simões, N. (2013). "A Serpin Released by an Entomopathogen Impairs Clot Formation in Insect Defense System", PLoS One. 8(7): e69161.
Carvalho, F., Duarte, J., Simões, A.R., Cruz, P.F., Jones, J.G. (2013). "Noninvasive Measurement of Murine Hepatic Acetyl-CoA 13C-Enrichment Following Overnight Feeding with 13C-Enriched Fructose and Glucose", BioMed Research International, Vol. 2013, Article ID 638085, 7 pages.
Silva, D.S., Pereira, L.M.G., Moreira, A.R., Ferreira-da-Silva, F., Brito, R.M.M., Faria, T.Q., Zornetta, I., Montecucco, C., Oliveira, P., Azevedo, J.E., Pereira, P.J.B., Macedo- Ribeiro, S., do Vale, A. and dos Santos, N.M.S. (2013). "The Apoptogenic Toxin AIP56 Is a Metalloprotease A-B Toxin that Cleaves NF-kappa b P65". PLOS Pathogens 9(2), e1003128.
Maia, J., Vazão, H., Pedroso, D.C.S., Jesus, C.S.H., Brito, R.M.M., Grãos, M., Gil, M.H. and Ferreira, L. (2012). "VEGF-Functionalized Dextran Has Longer Intracellular Bioactivity than VEGF in Endothelial Cells", Biomacromolecules 13 (9), pp 2906–2916.
Jesus, C.S.H., Vaz, D.C., Saraiva, M.J.M. and Brito, R.M.M. (2012). "The V30M Amyloidogenic Mutation Decreases the Rate of Refolding Kinetics of the Tetrameric Protein Transthyretin", Spectroscopy: An International Journal 27 (5-6), pp. 343–348.
Harley, C.A., Jesus, C.S.H., Carvalho, R., Brito, R.M.M., and Morais-Cabral, J.H. (2012). "Changes in Channel Trafficking and Protein Stability Caused by LQT2 Mutations in the PAS Domain of the HERG Channel", PLoS One. 7(3), pp. e32654. (Epub 2012 Mar 2.)
Fraga, A.S., Esteves, A.C., Micaelo, N., Cruz, P.F., Brito, R.M.M., Nutley, M., Cooper, A., Barros, M.M., and Pires, E.M. (2012). "Functional and conformational changes in the aspartic protease cardosin A induced by TFE", Int J Biol Macromol. 50(2), pp. 323-330. (Epub 2011 Dec 24.)
Camacho, R., Pereira, M., Costa, V.S., Fonseca, N.A., Adriano, C., Simões, C.J.V., and Brito, R.M.M. (2011). "A relational learning approach to structure-activity relationships in drug design toxicity studies", J. Integrative Bioinformatics 8(3): 182.
Henriques, E.S, Brito, R.M.M., Soares, H., Ventura, S., de Oliveira, V.L., Parkhouse, R.M.E. (2011) "Modeling of the Toll-like receptor 3 and a putative Toll-like receptor 3 antagonist encoded by the African swine fever virus", Protein Sci. 20(2), pp. 247-255.
Fraga, H., Faria, T.Q., Pinto, F., Almeida, A., Brito, R.M.M., Damas A.M. (2010) " FH8-a small EF-hand protein from Fasciola hepatica", FEBS J. 277(24), pp. 5072-5085.
Carvalho, V., Castanheira, P., Faria, T.Q., Gonçalves, C., Madureira, P., Faro, C., Domingues, L., Brito, R.M.M., Vilanova, M., Gama, M. (2010) "Biological activity of heterologous murine interleukin-10 and preliminary studies on the use of a dextrin nanogel as a delivery system", Int. J. Pharm. 400(1-2), pp. 234-42.
Simões, C.J.V., Mukherjee, T., Brito R.M.M., Jackson, R.M. (2010) "Toward the Discovery of Functional Transthyretin Amyloid Inhibitors: Application of Virtual Screening Methods", J. Chem. Inf. Model. 50(10), pp. 1806-1820.
Swain, M., Silva, C.G., Loureiro-Ferreira, N., Ostropytskyy, V., Brito, J., Stahl, F., Riche, O., Dubitzky, W., Brito, R.M.M. (2010) "P-found: grid-enabling distributed repositories of protein folding and unfolding simulations for data mining, Futur. Gener. Comp. Syst. 26 (3), pp. 424-433.
Rodrigues, J.R., Simões, C.J.V., Silva, C.G., Brito, R.M.M. (2010) "Potentially amyloidogenic conformational intermediates populate the unfolding landscape of transthyretin: insights from molecular dynamics simulations", Protein Sci. 19(2), pp. 202-219.
Simões, C.J.V., Rivero, A., Brito, R.M.M. (2010). Searching for Anti-Amyloid Drugs with the Help of Citizens: the “AMILOIDE” Project on the IBERCIVIS Platform. ERCIM News 82, pp. 25-26.
Simões, C.J.V., Rivero, A., Tarancón, A., Sanz, F.S., Romero, J.L., Abreu, P., Manuel, C., Durão, R., Rosa, J., Pagaime, J., Veiga, P., Jackson, R.M., Noronha, A., Vargas, R., Magalhães, L.T., Barreira, G., Brito, R.M.M. (2010) “Running faster and further together: the AMILOIDE project, the onset of the Portuguese participation on the Ibercivis volunteer computing network”, In Proceedings of IBERGRID’10, Braga, Portugal.
Pereira, M., Costa, V.S, Camacho, R., Fonseca, N.A., Simões, C.J.V., and Brito, R.M.M. (2009). Comparative Study of Classification Algorithms Using Molecular Descriptors in Toxicological DataBases. Lecture Notes in Bioinformatics 5676, pp. 121-132.
Silva, C.G., Ferreira, P.G., Azevedo, P.J., Brito, R.M.M. (2009) "Using data mining techniques to probe the role of hydrophobic residues in protein folding and unfolding simulations", In Pedro San-Bento Furtado (Ed.), Evolving application domains of data warehousing and mining: Trends and Solutions, Information Science Reference, Cap. 12, pp. 258-276.
Silva, C.G., Palma, R., Simões, J.R., Loureiro-Ferreira, N., Simões, C.J.V, Swain, M., Dubitzky, W., Brito, R.M.M. (2009) "P-found GRID: A Grid-enabled repository prototype for protein simulation data", Proceedings of the Third Iberian Grid Infractructure Conference, IBERGRID’ 2009, Valência, Espanha, pp. 54-61.
Ferreira, P.G., Silva, C.G., Azevedo, P.J., Brito, R.M.M (2008) "Spatial Clustering of Molecular Dynamics Trajectories in Protein Unfolding Simulations", Lecture Notes in Bioinformatics, vol. 5488, pp. 156-166, Springer-Verlag.
Swain, M., Ostropytskyy, V., Silva, C.G., Stahl, F., Riche, O., Brito, R.M.M., Dubitzky, W. (2008) "Grid computing solutions for distributed repositories of protein folding and unfolding simulations", Lecture Notes in Computer Sciences, vol. 5103, pp. 70-79, Springer.
Camacho, R., Alves, A., Silva, C.G., and Brito, R.M.M. (2008) "On Mining Protein Unfoling Simulation Data with Inductive Logic Programming", Advances in Soft Computing, vol. 49, pp. 175-179.
Fernandes, E., Jorge, A.M., Silva, C.G., Brito, R.M.M. (2008) "A knowledge discovery method for the characterization of protein unfolding processes", Advances in Soft Computing, vol. 49, pp. 180-188.
Silva, C.G., Brito,J., Swain,M., Dubitzky, W., Brito, R.M.M. (2008) "P-found GRID: A distributed repository for protein folding and unfolding simulations", Proceedings of the Second Iberian Grid Infractructure Conference, IBERGRID’2008, Porto, Portugal, pp. 152-162.
Soares, M.I.L, Lopes, S.M.M., Cruz, P.F., Brito, R.M.M., Melo, T.M.V.D.P. (2008) "Flash vacuum pyrolysis of 2,2-dioxo-1H,3H-pyrrolo[1,2-c]thiazoles and 2-vinyl-1H-pyrroles", Tetrahedron 41(11), pp. 9745-9753.
Ferreira, P.G., Silva, C.G., Brito, R.M.M., Azevedo, P.J. (2007) "A Closer Look on Protein Unfolding Simulations through Hierarchical Clustering", Proceedings of the 2007 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB’07, Honolulu, Hawai, pp. 461-468.
Ferreira, P.G., Azevedo, P.J., Brito, R.M.M, Silva, C.G. (2006) "Mining Approximate Motifs in Time Series", Lecture Notes in Artificial Intelligence, vol. 4265, p. 77-89.
Silva, C.G., Ostropytskyy, V., Loureiro-Ferreira, N., Berrar, D., Dubitzky, W., Brito, R.M.M. (2006) "P-found: The Protein Folding and Unfolding Simulation Repository", Proceedings of the 2006 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB’06, Toronto, Canadá, pp. 101-108.
Vaz, D.C., Rodrigues, J.R., Sebald, W., Dobson, C.M., Brito, R.M.M. (2006) "Enthalpic and entropic contributions mediate the role of disulfide bonds on the conformational stability of interleukin-4", Protein Sci. 15(1), pp. 33-44.
Correia, B.E., Loureiro-Ferreira, N., Rodrigues, J.R., Brito, R.M.M. (2006) "A structural model of an amyloid protofilament of transthyretin", Protein Sci. 15(1), pp. 28-32.
Azevedo, P.J., Silva, C.G, Rodrigues, J.R., Loureiro-Ferreira, N., Brito, R.M.M. (2005) "Detection of Hydrophobic Clusters in Molecular Dynamics Protein Unfolding Simulations Using Association Rules", Lecture Notes in Computer Sciences, vol. 3725, pp. 329-337.
Berrar, D., Stahl, F., Silva, C.G., Brito, R.M.M, Dubitzky, W. (2005) "Towards data warehousing, mining of protein unfolding simulation data", J. Clin. Monit. Comput. 15(4-5), pp. 307-317.
Stahl, F., Berrar, D., Silva, C.G., Rodrigues, J.R., Brito, R.M.M., Dubitzky, W. (2005) "Grid warehousing of molecular dynamics protein unfolding data", Proceedings of the IEEE International Symposium on Cluster Computing and the Grid, CCGrid 2005, vol. 1, pp. 496-503.
Brito, R.M.M., Dubitzky, W., Rodrigues, J.R. (2004) "Protein folding and unfolding simulations: a new challenge for data mining", OMICS 8(2), pp. 153-166.
Brito, R. M. M., Damas, A. M., and Saraiva, M. J. S. (2003). Amyloid Formation by Transthyretin: From Protein Stability to Protein Aggregation (review). Current Medicinal Chemistry - Immun. Endoc. & Metab. Agents 3(4), pp. 349-360.
Quintas, A., Vaz, D.C., Cardoso, I., Saraiva, M.J., Brito, R.M.M. (2001) "Tetramer dissociation and monomer partial unfolding precedes protofibril formation in amyloidogenic transthyretin variants", J. Biol. Chem. 276(29), pp. 27207-27213.
Shnyrov, V.L., Villar, E., Zhadan, G.G., Sanchez-Ruiz, J.M., Quintas, A., Saraiva, M.J.M., Brito, R.M.M. (2000) "Comparative calorimetric study of non-amyloidogenic and amyloidogenic variants of the homotetrameric protein transthyretin", Biophys. Chem. 88(1-3), pp. 61-67.
Quintas, A., Saraiva, M.J.M., Brito, R.M.M. (1999) "The tetrameric protein transthyretin dissociates to a non-native monomer in solution. A novel model for amyloidogenesis", J. Biol. Chem. 274(46), pp. 32943-32949.
Quintas, A., Saraiva, M.J.M., Brito, R.M.M. (1997) "The amyloidogenic potential of transthyretin variants correlates with their tendency to aggregate in solution", FEBS Lett. 418(3), pp. 297-300.